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Loss of Atp8a2 drives neurodegeneration through the dysregulation of spatiotemporal phosphatidylserine externalization in mature neurons.

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Title: Loss of Atp8a2 drives neurodegeneration through the dysregulation of spatiotemporal phosphatidylserine externalization in mature neurons.
Authors: Schneider A; Department of Neurobiology, Interdisciplinary Centre for Neurosciences (IZN), Heidelberg University, Heidelberg, Germany., Merkel AB; Department of Neurobiology, Interdisciplinary Centre for Neurosciences (IZN), Heidelberg University, Heidelberg, Germany., Perta N; Department of Life and Environmental Sciences, Marche Polytechnic University, Ancona, Italy.; Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Ruff L; Department of Neurobiology, Interdisciplinary Centre for Neurosciences (IZN), Heidelberg University, Heidelberg, Germany., Ussyshkin N; Department of Neurobiology, Interdisciplinary Centre for Neurosciences (IZN), Heidelberg University, Heidelberg, Germany., Zimmer P; Department of Neurobiology, Interdisciplinary Centre for Neurosciences (IZN), Heidelberg University, Heidelberg, Germany., Aksan B; Department of Neurobiology, Interdisciplinary Centre for Neurosciences (IZN), Heidelberg University, Heidelberg, Germany., Lepeuve A; Department of Neurobiology, Interdisciplinary Centre for Neurosciences (IZN), Heidelberg University, Heidelberg, Germany.; Dept. Molecular and Cellular Neuroscience, Institute of Anatomy and Cell Biology, Marburg University, Marburg, Germany., D'Andrea L; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy., Pelucchi S; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy., Marcello E; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy., Di Marino D; Department of Life and Environmental Sciences, Marche Polytechnic University, Ancona, Italy.; Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Mauceri D; Department of Neurobiology, Interdisciplinary Centre for Neurosciences (IZN), Heidelberg University, Heidelberg, Germany. mauceri@uni-marburg.de.; Dept. Molecular and Cellular Neuroscience, Institute of Anatomy and Cell Biology, Marburg University, Marburg, Germany. mauceri@uni-marburg.de.
Source: Cell death & disease [Cell Death Dis] 2026 Jul 22; Vol. 17 (1). Date of Electronic Publication: 2026 Jul 22.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101524092 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-4889 (Electronic) NLM ISO Abbreviation: Cell Death Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Loss of Atp8a2 drives neurodegeneration through the dysregulation of spatiotemporal phosphatidylserine externalization in mature neurons.
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  Data: <searchLink fieldCode="AU" term="%22Schneider+A%22">Schneider A</searchLink>; Department of Neurobiology, Interdisciplinary Centre for Neurosciences (IZN), Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Merkel+AB%22">Merkel AB</searchLink>; Department of Neurobiology, Interdisciplinary Centre for Neurosciences (IZN), Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Perta+N%22">Perta N</searchLink>; Department of Life and Environmental Sciences, Marche Polytechnic University, Ancona, Italy.; Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Ruff+L%22">Ruff L</searchLink>; Department of Neurobiology, Interdisciplinary Centre for Neurosciences (IZN), Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Ussyshkin+N%22">Ussyshkin N</searchLink>; Department of Neurobiology, Interdisciplinary Centre for Neurosciences (IZN), Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Zimmer+P%22">Zimmer P</searchLink>; Department of Neurobiology, Interdisciplinary Centre for Neurosciences (IZN), Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Aksan+B%22">Aksan B</searchLink>; Department of Neurobiology, Interdisciplinary Centre for Neurosciences (IZN), Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Lepeuve+A%22">Lepeuve A</searchLink>; Department of Neurobiology, Interdisciplinary Centre for Neurosciences (IZN), Heidelberg University, Heidelberg, Germany.; Dept. Molecular and Cellular Neuroscience, Institute of Anatomy and Cell Biology, Marburg University, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22D'Andrea+L%22">D'Andrea L</searchLink>; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Pelucchi+S%22">Pelucchi S</searchLink>; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Marcello+E%22">Marcello E</searchLink>; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Marino+D%22">Di Marino D</searchLink>; Department of Life and Environmental Sciences, Marche Polytechnic University, Ancona, Italy.; Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Mauceri+D%22">Mauceri D</searchLink>; Department of Neurobiology, Interdisciplinary Centre for Neurosciences (IZN), Heidelberg University, Heidelberg, Germany. mauceri@uni-marburg.de.; Dept. Molecular and Cellular Neuroscience, Institute of Anatomy and Cell Biology, Marburg University, Marburg, Germany. mauceri@uni-marburg.de.
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  Data: <searchLink fieldCode="JN" term="%22101524092%22">Cell death & disease</searchLink> [Cell Death Dis] 2026 Jul 22; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 Jul 22.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101524092 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-4889 (Electronic) <i>NLM ISO Abbreviation: </i>Cell Death Dis <i>Subsets: </i>MEDLINE
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