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Lipids in ovarian cancer ascites impair T cell activation by disrupting TCR dynamics.

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Title: Lipids in ovarian cancer ascites impair T cell activation by disrupting TCR dynamics.
Authors: Brown EG; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA.; Department of Pharmacology, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA., Compeer EB; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Kennedy Institute of Rheumatology and CAMS Oxford Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, University of Oxford, Oxford, UK., Gan Z; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Kelly AR; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Shestov AA; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Córdoba-Espejo L; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; H12O-CNIO Hematological Malignancies Clinical Research Unit, Spanish National Cancer Research Centre, Madrid, Spain., Evans MT; Optics11 Life Inc., Boston, MA, USA., Liu AY; Optics11 Life Inc., Boston, MA, USA., Naughton NH; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA., Parnaik TS; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA., Larson JH; Department of Pediatrics, Division of Blood and Marrow Transplant and Cell Therapy, University of Minnesota, Minneapolis, MN, USA., Blazar BR; Department of Pediatrics, Division of Blood and Marrow Transplant and Cell Therapy, University of Minnesota, Minneapolis, MN, USA., Bartman CR; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA., Rabinowitz JD; Department of Chemistry, Princeton University, Princeton, NJ, USA.; Lewis-Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ, USA.; Ludwig Institute for Cancer Research, Princeton Branch, Princeton University, Princeton, NJ, USA., Dustin ML; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Kennedy Institute of Rheumatology and CAMS Oxford Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, University of Oxford, Oxford, UK., Powell DJ Jr; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA.; Department of Pharmacology, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA., O'Connor RS; Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. oconnorr@pennmedicine.upenn.edu.; Department of Pathology and Laboratory Medicine, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA. oconnorr@pennmedicine.upenn.edu.
Source: Nature metabolism [Nat Metab] 2026 Jul 22. Date of Electronic Publication: 2026 Jul 22.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE
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