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Tertiary lymphoid structures harbour stem-like tumour-specific T cells.

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Title: Tertiary lymphoid structures harbour stem-like tumour-specific T cells.
Authors: Afeyan AB; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Nagler A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Tu CR; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA., Roberti De Oliveira G; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA., Simsek B; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA., Seager MD; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA., El Ahmar N; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA., Sax HE; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Lin E; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Sud A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Centre for Immuno-Oncology, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Borji M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Forman C; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA., Liu S; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Ragon Institute of MGB, MIT and Harvard, Cambridge, MA, USA., Ott PA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Choueiri TK; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Abelin JG; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Burack R; University of Rochester Medical Center, Department of Pathology and Laboratory Medicine, Rochester, NY, USA., Li S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA, USA., Livak KJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA, USA., Tyekucheva S; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA., Keskin DB; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Computer Science, Metropolitan College, Boston University, Boston, MA, USA.; Section for Bioinformatics, Department of Health Technology, Technical University of Denmark, Lyngby, Denmark., Chen F; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Atkins MB; Georgetown Lombardi Comprehensive Cancer Center, Washington, DC, USA., Simon JM; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Signoretti S; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA., Oliveira G; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. giacomo_oliveira@dfci.harvard.edu.; Harvard Medical School, Boston, MA, USA. giacomo_oliveira@dfci.harvard.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. giacomo_oliveira@dfci.harvard.edu., Braun DA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. david.braun@yale.edu.; Section of Medical Oncology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA. david.braun@yale.edu.; Center of Molecular and Cellular Oncology, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA. david.braun@yale.edu., Wu CJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. catherine_wu@dfci.harvard.edu.; Harvard Medical School, Boston, MA, USA. catherine_wu@dfci.harvard.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. catherine_wu@dfci.harvard.edu.
Source: Nature [Nature] 2026 Jul 22. Date of Electronic Publication: 2026 Jul 22.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Afeyan+AB%22">Afeyan AB</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Nagler+A%22">Nagler A</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Tu+CR%22">Tu CR</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Roberti+De+Oliveira+G%22">Roberti De Oliveira G</searchLink>; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Simsek+B%22">Simsek B</searchLink>; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Seager+MD%22">Seager MD</searchLink>; 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Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Translational Immunogenomics Laboratory, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Computer Science, Metropolitan College, Boston University, Boston, MA, USA.; Section for Bioinformatics, Department of Health Technology, Technical University of Denmark, Lyngby, Denmark.<br /><searchLink fieldCode="AU" term="%22Chen+F%22">Chen F</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Atkins+MB%22">Atkins MB</searchLink>; Georgetown Lombardi Comprehensive Cancer Center, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Simon+JM%22">Simon JM</searchLink>; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biostatistics, Harvard T. 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Chan School of Public Health, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Signoretti+S%22">Signoretti S</searchLink>; Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Oliveira+G%22">Oliveira G</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. giacomo_oliveira@dfci.harvard.edu.; Harvard Medical School, Boston, MA, USA. giacomo_oliveira@dfci.harvard.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. giacomo_oliveira@dfci.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Braun+DA%22">Braun DA</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. david.braun@yale.edu.; Section of Medical Oncology, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA. david.braun@yale.edu.; Center of Molecular and Cellular Oncology, Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA. david.braun@yale.edu.<br /><searchLink fieldCode="AU" term="%22Wu+CJ%22">Wu CJ</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. catherine_wu@dfci.harvard.edu.; Harvard Medical School, Boston, MA, USA. catherine_wu@dfci.harvard.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. catherine_wu@dfci.harvard.edu.
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