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FUS controls muscle differentiation through phase separation-mediated recruitment of the transcription factors MEF2 and ETV5.

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Title: FUS controls muscle differentiation through phase separation-mediated recruitment of the transcription factors MEF2 and ETV5.
Authors: Picchiarelli G; Université de Strasbourg, Inserm, Strasbourg Translational Neuroscience and Psychiatry, UMR-S1329, Centre de Recherches en Biomédecine, Strasbourg, France., Wienand A; Molecular Neurobiology Laboratory, Donders Institute for Brain, Cognition and Behaviour and Faculty of Science, Radboud University, Nijmegen, Netherlands., Megat S; Université de Strasbourg, Inserm, Strasbourg Translational Neuroscience and Psychiatry, UMR-S1329, Centre de Recherches en Biomédecine, Strasbourg, France., Hutten S; Institute of Molecular Physiology, Johannes Gutenberg-Universität (JGU), Mainz, Germany., Aly A; Institute of Anatomy and Cell Biology, Ulm University, Ulm, Germany., Been M; Molecular Neurobiology Laboratory, Donders Institute for Brain, Cognition and Behaviour and Faculty of Science, Radboud University, Nijmegen, Netherlands., Weber I; Université de Strasbourg, Inserm, Strasbourg Translational Neuroscience and Psychiatry, UMR-S1329, Centre de Recherches en Biomédecine, Strasbourg, France., Bonanno A; Université de Strasbourg, Inserm, Strasbourg Translational Neuroscience and Psychiatry, UMR-S1329, Centre de Recherches en Biomédecine, Strasbourg, France., Mishra N; Department of Neurology, The Sean M. Healey and AMG Center for ALS, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Sternburg E; Institute of Molecular Physiology, Johannes Gutenberg-Universität (JGU), Mainz, Germany., Cauchy P; Université de Strasbourg, Inserm, Strasbourg Translational Neuroscience and Psychiatry, UMR-S1329, Centre de Recherches en Biomédecine, Strasbourg, France., Dieterle S; Université de Strasbourg, Inserm, Strasbourg Translational Neuroscience and Psychiatry, UMR-S1329, Centre de Recherches en Biomédecine, Strasbourg, France., Catinozzi M; Molecular Neurobiology Laboratory, Donders Institute for Brain, Cognition and Behaviour and Faculty of Science, Radboud University, Nijmegen, Netherlands., Lobo-Mancheno J; Molecular Neurobiology Laboratory, Donders Institute for Brain, Cognition and Behaviour and Faculty of Science, Radboud University, Nijmegen, Netherlands., Walgrave H; Molecular Neurobiology Laboratory, Donders Institute for Brain, Cognition and Behaviour and Faculty of Science, Radboud University, Nijmegen, Netherlands., Demais V; Plateforme Imagerie In Vitro, CNRS UPS-3156, NeuroPôle, Strasbourg, France.; Université de Strasbourg, INSERM, UMS 38, Imaging Core Facility PIC-STRA, CRBS, Strasbourg, France., Hener P; Plateforme Imagerie In Vitro, CNRS UPS-3156, NeuroPôle, Strasbourg, France., Kessler P; Université de Strasbourg, INSERM, UMS 38, Imaging Core Facility PIC-STRA, CRBS, Strasbourg, France., Tzeplaeff L; Université de Strasbourg, Inserm, Strasbourg Translational Neuroscience and Psychiatry, UMR-S1329, Centre de Recherches en Biomédecine, Strasbourg, France.; Université de Strasbourg, UMR 7364 CNRS, Laboratoire de Neurosciences Cognitives et Adaptatives (LNCA), Strasbourg, France., Huebers A; Department of Neurology, Heinrich Heine-University, Düsseldorf, Germany., Zeuschner D; Electron Microscopy Unit, Max Planck Institute for Molecular Biomedicine, Münster, Germany., Rosenbohm A; Department of Neurology, Ulm University, Ulm, Germany., Ludolph AC; Department of Neurology, Ulm University, Ulm, Germany.; German Center for Neurodegenerative Diseases (DZNE) Ulm, Ulm, Germany., Boutillier AL; Université de Strasbourg, UMR 7364 CNRS, Laboratoire de Neurosciences Cognitives et Adaptatives (LNCA), Strasbourg, France., Boeckers T; Institute of Molecular Physiology, Johannes Gutenberg-Universität (JGU), Mainz, Germany.; German Center for Neurodegenerative Diseases (DZNE) Ulm, Ulm, Germany., Dormann D; Institute of Molecular Physiology, Johannes Gutenberg-Universität (JGU), Mainz, Germany.; Institute of Molecular Biology (IMB), Mainz, Germany., Demestre M; Institute of Anatomy and Cell Biology, Ulm University, Ulm, Germany., Sellier C; Université de Strasbourg, Inserm, Strasbourg Translational Neuroscience and Psychiatry, UMR-S1329, Centre de Recherches en Biomédecine, Strasbourg, France. chantal.sellier@inserm.fr., Lagier-Tourenne C; Department of Neurology, The Sean M. Healey and AMG Center for ALS, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. clagier-tourenne@mgh.harvard.edu., Storkebaum E; Molecular Neurobiology Laboratory, Donders Institute for Brain, Cognition and Behaviour and Faculty of Science, Radboud University, Nijmegen, Netherlands. erik.storkebaum@donders.ru.nl., Dupuis L; Université de Strasbourg, Inserm, Strasbourg Translational Neuroscience and Psychiatry, UMR-S1329, Centre de Recherches en Biomédecine, Strasbourg, France. ldupuis@unistra.fr.
Source: The EMBO journal [EMBO J] 2026 Jul 22. Date of Electronic Publication: 2026 Jul 22.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
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  Data: FUS controls muscle differentiation through phase separation-mediated recruitment of the transcription factors MEF2 and ETV5.
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