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Methylation profiling and alternative classification approaches in a glioma-enriched FFPE stereotaxic biopsy cohort.

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Title: Methylation profiling and alternative classification approaches in a glioma-enriched FFPE stereotaxic biopsy cohort.
Authors: Weber KJ; Goethe University Frankfurt, University Hospital, Neurological Institute (Edinger Institute), Heinrich-Hoffmann-Straße 7, 60528, Frankfurt am Main, Germany. K.Weber@med.uni-frankfurt.de.; German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Partner Site Frankfurt, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. K.Weber@med.uni-frankfurt.de.; Frankfurt Cancer Institute (FCI), Paul-Ehrlich-Str. 42-44, 60596, Frankfurt am Main, Germany. K.Weber@med.uni-frankfurt.de.; Goethe University Frankfurt, University Hospital, University Cancer Center (UCT), Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany. K.Weber@med.uni-frankfurt.de., Hench J; Division of Neuropathology, Institute of Pathology, Basel University Hospital, Schönbeinstrasse 40, 4031, Basel, Switzerland., Zumpt M; Goethe University Frankfurt, University Hospital, Neurological Institute (Edinger Institute), Heinrich-Hoffmann-Straße 7, 60528, Frankfurt am Main, Germany., Eska T; Ludwig Maximilians University Munich, University Hospital, Center for Neuropathology and Prion Research, Faculty of Medicine, Feodor-Lynen-Straße 23, 81377, Munich, Germany.; German Cancer Consortium (DKTK), Partner Site Munich, A Partnership Between German CancerResearch Center (DKFZ) and University/University Hospital, Ludwig Maximilians University Munich, Marchioninistraße 15, 81377, Munich, Germany., Armbrust M; Goethe University Frankfurt, University Hospital, Neurological Institute (Edinger Institute), Heinrich-Hoffmann-Straße 7, 60528, Frankfurt am Main, Germany.; German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Partner Site Frankfurt, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.; Frankfurt Cancer Institute (FCI), Paul-Ehrlich-Str. 42-44, 60596, Frankfurt am Main, Germany.; Goethe University Frankfurt, University Hospital, University Cancer Center (UCT), Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany., Zeiner PS; German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Partner Site Frankfurt, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.; Frankfurt Cancer Institute (FCI), Paul-Ehrlich-Str. 42-44, 60596, Frankfurt am Main, Germany.; Goethe University Frankfurt, University Hospital, University Cancer Center (UCT), Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.; Goethe University Frankfurt, University Hospital, Dr. Senckenberg Institute of Neurooncology, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.; Goethe University Frankfurt, University Hospital, Department of Neurology, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany., Hartung TI; University Hospital Hamburg-Eppendorf, Martinistraße 52, 20251, Hamburg, Germany., Ruf V; Ludwig Maximilians University Munich, University Hospital, Center for Neuropathology and Prion Research, Faculty of Medicine, Feodor-Lynen-Straße 23, 81377, Munich, Germany., Steidl E; Goethe University Frankfurt, University Hospital, Institute of Neuroradiology, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany., Dettki M; Goethe University Frankfurt, University Hospital, Dr. Senckenberg Institute of Neurooncology, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany., Fenton T; School of Cancer Sciences, University of Southampton, University Road, Southampton, SO17 1BJ, UK., Steinbach JP; German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Partner Site Frankfurt, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.; Frankfurt Cancer Institute (FCI), Paul-Ehrlich-Str. 42-44, 60596, Frankfurt am Main, Germany.; Goethe University Frankfurt, University Hospital, Dr. Senckenberg Institute of Neurooncology, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany., Czabanka M; Goethe University Frankfurt, University Hospital, Department of Neurosurgery, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany., Capper D; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Neuropathology, Charitéplatz 1, 10117, Berlin, Germany.; German Cancer Consortium (DKTK), Partner Site Berlin and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany., Frank S; Division of Neuropathology, Institute of Pathology, Basel University Hospital, Schönbeinstrasse 40, 4031, Basel, Switzerland., Plate KH; Goethe University Frankfurt, University Hospital, Neurological Institute (Edinger Institute), Heinrich-Hoffmann-Straße 7, 60528, Frankfurt am Main, Germany.; German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Partner Site Frankfurt, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.; Frankfurt Cancer Institute (FCI), Paul-Ehrlich-Str. 42-44, 60596, Frankfurt am Main, Germany.; Goethe University Frankfurt, University Hospital, University Cancer Center (UCT), Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany., Forster MT; Goethe University Frankfurt, University Hospital, Department of Neurosurgery, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany., Harter PN; Ludwig Maximilians University Munich, University Hospital, Center for Neuropathology and Prion Research, Faculty of Medicine, Feodor-Lynen-Straße 23, 81377, Munich, Germany.; German Cancer Consortium (DKTK), Partner Site Munich, A Partnership Between German CancerResearch Center (DKFZ) and University/University Hospital, Ludwig Maximilians University Munich, Marchioninistraße 15, 81377, Munich, Germany.; Bavarian Center for Cancer Research (BZKF), Partner Site Munich, Marchioninistraße 15, 81377, Munich, Germany.
Source: Acta neuropathologica communications [Acta Neuropathol Commun] 2026 Jul 22; Vol. 14 (1). Date of Electronic Publication: 2026 Jul 22.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Weber+KJ%22">Weber KJ</searchLink>; Goethe University Frankfurt, University Hospital, Neurological Institute (Edinger Institute), Heinrich-Hoffmann-Straße 7, 60528, Frankfurt am Main, Germany. K.Weber@med.uni-frankfurt.de.; German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Partner Site Frankfurt, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. K.Weber@med.uni-frankfurt.de.; Frankfurt Cancer Institute (FCI), Paul-Ehrlich-Str. 42-44, 60596, Frankfurt am Main, Germany. K.Weber@med.uni-frankfurt.de.; Goethe University Frankfurt, University Hospital, University Cancer Center (UCT), Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany. K.Weber@med.uni-frankfurt.de.<br /><searchLink fieldCode="AU" term="%22Hench+J%22">Hench J</searchLink>; Division of Neuropathology, Institute of Pathology, Basel University Hospital, Schönbeinstrasse 40, 4031, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Zumpt+M%22">Zumpt M</searchLink>; Goethe University Frankfurt, University Hospital, Neurological Institute (Edinger Institute), Heinrich-Hoffmann-Straße 7, 60528, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Eska+T%22">Eska T</searchLink>; Ludwig Maximilians University Munich, University Hospital, Center for Neuropathology and Prion Research, Faculty of Medicine, Feodor-Lynen-Straße 23, 81377, Munich, Germany.; German Cancer Consortium (DKTK), Partner Site Munich, A Partnership Between German CancerResearch Center (DKFZ) and University/University Hospital, Ludwig Maximilians University Munich, Marchioninistraße 15, 81377, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Armbrust+M%22">Armbrust M</searchLink>; Goethe University Frankfurt, University Hospital, Neurological Institute (Edinger Institute), Heinrich-Hoffmann-Straße 7, 60528, Frankfurt am Main, Germany.; German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Partner Site Frankfurt, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.; Frankfurt Cancer Institute (FCI), Paul-Ehrlich-Str. 42-44, 60596, Frankfurt am Main, Germany.; Goethe University Frankfurt, University Hospital, University Cancer Center (UCT), Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Zeiner+PS%22">Zeiner PS</searchLink>; German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Partner Site Frankfurt, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.; Frankfurt Cancer Institute (FCI), Paul-Ehrlich-Str. 42-44, 60596, Frankfurt am Main, Germany.; Goethe University Frankfurt, University Hospital, University Cancer Center (UCT), Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.; Goethe University Frankfurt, University Hospital, Dr. Senckenberg Institute of Neurooncology, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.; Goethe University Frankfurt, University Hospital, Department of Neurology, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Hartung+TI%22">Hartung TI</searchLink>; University Hospital Hamburg-Eppendorf, Martinistraße 52, 20251, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Ruf+V%22">Ruf V</searchLink>; Ludwig Maximilians University Munich, University Hospital, Center for Neuropathology and Prion Research, Faculty of Medicine, Feodor-Lynen-Straße 23, 81377, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Steidl+E%22">Steidl E</searchLink>; Goethe University Frankfurt, University Hospital, Institute of Neuroradiology, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Dettki+M%22">Dettki M</searchLink>; Goethe University Frankfurt, University Hospital, Dr. Senckenberg Institute of Neurooncology, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Fenton+T%22">Fenton T</searchLink>; School of Cancer Sciences, University of Southampton, University Road, Southampton, SO17 1BJ, UK.<br /><searchLink fieldCode="AU" term="%22Steinbach+JP%22">Steinbach JP</searchLink>; German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Partner Site Frankfurt, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.; Frankfurt Cancer Institute (FCI), Paul-Ehrlich-Str. 42-44, 60596, Frankfurt am Main, Germany.; Goethe University Frankfurt, University Hospital, Dr. Senckenberg Institute of Neurooncology, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Czabanka+M%22">Czabanka M</searchLink>; Goethe University Frankfurt, University Hospital, Department of Neurosurgery, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Capper+D%22">Capper D</searchLink>; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Neuropathology, Charitéplatz 1, 10117, Berlin, Germany.; German Cancer Consortium (DKTK), Partner Site Berlin and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Frank+S%22">Frank S</searchLink>; Division of Neuropathology, Institute of Pathology, Basel University Hospital, Schönbeinstrasse 40, 4031, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Plate+KH%22">Plate KH</searchLink>; Goethe University Frankfurt, University Hospital, Neurological Institute (Edinger Institute), Heinrich-Hoffmann-Straße 7, 60528, Frankfurt am Main, Germany.; German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Partner Site Frankfurt, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.; Frankfurt Cancer Institute (FCI), Paul-Ehrlich-Str. 42-44, 60596, Frankfurt am Main, Germany.; Goethe University Frankfurt, University Hospital, University Cancer Center (UCT), Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Forster+MT%22">Forster MT</searchLink>; Goethe University Frankfurt, University Hospital, Department of Neurosurgery, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Harter+PN%22">Harter PN</searchLink>; Ludwig Maximilians University Munich, University Hospital, Center for Neuropathology and Prion Research, Faculty of Medicine, Feodor-Lynen-Straße 23, 81377, Munich, Germany.; German Cancer Consortium (DKTK), Partner Site Munich, A Partnership Between German CancerResearch Center (DKFZ) and University/University Hospital, Ludwig Maximilians University Munich, Marchioninistraße 15, 81377, Munich, Germany.; Bavarian Center for Cancer Research (BZKF), Partner Site Munich, Marchioninistraße 15, 81377, Munich, Germany.
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