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Identification of AAV Vector Integration Sites in Primary Human and Macaque Hepatocytes in vivo, and Analysis of Oncogenic Risk.

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Title: Identification of AAV Vector Integration Sites in Primary Human and Macaque Hepatocytes in vivo, and Analysis of Oncogenic Risk.
Authors: Scott S; Translational Vectorology Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, New South Wales 2145, Australia., Hallwirth CV; Gene Therapy Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney and Sydney Children's Hospitals Network, Westmead, New South Wales 2145, Australia., Sasaki N; Gene Therapy Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney and Sydney Children's Hospitals Network, Westmead, New South Wales 2145, Australia., Cunningham SC; Viral Vector Manufacturing Facility, Westmead, New South Wales 2145, Australia., Zhu E; Gene Therapy Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney and Sydney Children's Hospitals Network, Westmead, New South Wales 2145, Australia., Khandekar N; Gene Therapy Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney and Sydney Children's Hospitals Network, Westmead, New South Wales 2145, Australia., Kizana E; Centre for Heart Research, Westmead Institute for Medical Research, The University of Sydney, Westmead, New South Wales 2145, Australia., Baruteau J; Great Ormond Street Institute of Child Health, University College London, London WC1E 1EH, United Kingdom., Gissen P; Great Ormond Street Institute of Child Health, University College London, London WC1E 1EH, United Kingdom., Perocheau DP; Great Ormond Street Institute of Child Health, University College London, London WC1E 1EH, United Kingdom., Bauer DC; Australian e-Health Research Centre, Commonwealth Scientific and Industrial Research Organisation, Sydney, New South Wales 2145, Australia., Wilson LOW; Australian e-Health Research Centre, Commonwealth Scientific and Industrial Research Organisation, Sydney, New South Wales 2145, Australia; Applied BioSciences, Faculty of Science and Engineering, Commonwealth Scientific and Industrial Research Organisation, Sydney, NSW, 2145, Australia., Lisowski L; Translational Vectorology Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, New South Wales 2145, Australia; Viral Vector Manufacturing Facility, Westmead, New South Wales 2145, Australia; Military Institute of Medicine - National Research Institute, 04-141 Warsaw, Poland., Alexander IE; Gene Therapy Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney and Sydney Children's Hospitals Network, Westmead, New South Wales 2145, Australia; Viral Vector Manufacturing Facility, Westmead, New South Wales 2145, Australia; Discipline of Child and Adolescent Health, Faculty of Medicine and Health, The University of Sydney, Westmead, New South Wales 2145, Australia. Electronic address: ian.alexander@health.nsw.gov.au.
Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2026 Jul 22. Date of Electronic Publication: 2026 Jul 22.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Identification of AAV Vector Integration Sites in Primary Human and Macaque Hepatocytes in vivo, and Analysis of Oncogenic Risk.
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  Data: <searchLink fieldCode="AU" term="%22Scott+S%22">Scott S</searchLink>; Translational Vectorology Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, New South Wales 2145, Australia.<br /><searchLink fieldCode="AU" term="%22Hallwirth+CV%22">Hallwirth CV</searchLink>; Gene Therapy Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney and Sydney Children's Hospitals Network, Westmead, New South Wales 2145, Australia.<br /><searchLink fieldCode="AU" term="%22Sasaki+N%22">Sasaki N</searchLink>; Gene Therapy Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney and Sydney Children's Hospitals Network, Westmead, New South Wales 2145, Australia.<br /><searchLink fieldCode="AU" term="%22Cunningham+SC%22">Cunningham SC</searchLink>; Viral Vector Manufacturing Facility, Westmead, New South Wales 2145, Australia.<br /><searchLink fieldCode="AU" term="%22Zhu+E%22">Zhu E</searchLink>; Gene Therapy Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney and Sydney Children's Hospitals Network, Westmead, New South Wales 2145, Australia.<br /><searchLink fieldCode="AU" term="%22Khandekar+N%22">Khandekar N</searchLink>; Gene Therapy Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney and Sydney Children's Hospitals Network, Westmead, New South Wales 2145, Australia.<br /><searchLink fieldCode="AU" term="%22Kizana+E%22">Kizana E</searchLink>; Centre for Heart Research, Westmead Institute for Medical Research, The University of Sydney, Westmead, New South Wales 2145, Australia.<br /><searchLink fieldCode="AU" term="%22Baruteau+J%22">Baruteau J</searchLink>; Great Ormond Street Institute of Child Health, University College London, London WC1E 1EH, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Gissen+P%22">Gissen P</searchLink>; Great Ormond Street Institute of Child Health, University College London, London WC1E 1EH, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Perocheau+DP%22">Perocheau DP</searchLink>; Great Ormond Street Institute of Child Health, University College London, London WC1E 1EH, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Bauer+DC%22">Bauer DC</searchLink>; Australian e-Health Research Centre, Commonwealth Scientific and Industrial Research Organisation, Sydney, New South Wales 2145, Australia.<br /><searchLink fieldCode="AU" term="%22Wilson+LOW%22">Wilson LOW</searchLink>; Australian e-Health Research Centre, Commonwealth Scientific and Industrial Research Organisation, Sydney, New South Wales 2145, Australia; Applied BioSciences, Faculty of Science and Engineering, Commonwealth Scientific and Industrial Research Organisation, Sydney, NSW, 2145, Australia.<br /><searchLink fieldCode="AU" term="%22Lisowski+L%22">Lisowski L</searchLink>; Translational Vectorology Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, New South Wales 2145, Australia; Viral Vector Manufacturing Facility, Westmead, New South Wales 2145, Australia; Military Institute of Medicine - National Research Institute, 04-141 Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Alexander+IE%22">Alexander IE</searchLink>; Gene Therapy Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney and Sydney Children's Hospitals Network, Westmead, New South Wales 2145, Australia; Viral Vector Manufacturing Facility, Westmead, New South Wales 2145, Australia; Discipline of Child and Adolescent Health, Faculty of Medicine and Health, The University of Sydney, Westmead, New South Wales 2145, Australia. Electronic address: ian.alexander@health.nsw.gov.au.
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      – TitleFull: Identification of AAV Vector Integration Sites in Primary Human and Macaque Hepatocytes in vivo, and Analysis of Oncogenic Risk.
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