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Preclinical evaluation of the ROR1-targeting antibody-drug conjugates zilovertamab vedotin and VLS-211 against B-cell ALL patient-derived xenografts.

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Title: Preclinical evaluation of the ROR1-targeting antibody-drug conjugates zilovertamab vedotin and VLS-211 against B-cell ALL patient-derived xenografts.
Authors: Smith CM; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health UNSW Centre for Childhood Cancer Research, UNSW Sydney Sydney New South Wales Australia., Watts B; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health UNSW Centre for Childhood Cancer Research, UNSW Sydney Sydney New South Wales Australia., Evans K; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health UNSW Centre for Childhood Cancer Research, UNSW Sydney Sydney New South Wales Australia., Kosasih H; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health UNSW Centre for Childhood Cancer Research, UNSW Sydney Sydney New South Wales Australia., Mayoh C; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health UNSW Centre for Childhood Cancer Research, UNSW Sydney Sydney New South Wales Australia., Erickson SW; RTI International, Research Triangle Park North Carolina USA., Earley EJ; RTI International, Research Triangle Park North Carolina USA., Neuhauser S; The Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA., Stearns TM; The Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA., Philip VM; The Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA., Chuang JH; The Jackson Laboratory for Genomic Medicine Farmington Connecticut USA., de Bock CE; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health UNSW Centre for Childhood Cancer Research, UNSW Sydney Sydney New South Wales Australia., Bowman EP; Department of Oncology Merck & Co. Inc. Rahway New Jersey USA., Jessen KA; Formerly VelosBio Inc. San Diego California USA., Jocoy EL; The Jackson Laboratory Sacramento California USA., Bult CJ; The Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA., Teicher BA; National Cancer Institute Bethesda Maryland USA., Smith MA; National Cancer Institute Bethesda Maryland USA., Lock RB; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health UNSW Centre for Childhood Cancer Research, UNSW Sydney Sydney New South Wales Australia.
Source: HemaSphere [Hemasphere] 2026 Jul 22; Vol. 10 (7), pp. e70438. Date of Electronic Publication: 2026 Jul 22 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 101740619 Publication Model: eCollection Cited Medium: Internet ISSN: 2572-9241 (Electronic) Linking ISSN: 25729241 NLM ISO Abbreviation: Hemasphere Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Smith+CM%22">Smith CM</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health UNSW Centre for Childhood Cancer Research, UNSW Sydney Sydney New South Wales Australia.<br /><searchLink fieldCode="AU" term="%22Watts+B%22">Watts B</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health UNSW Centre for Childhood Cancer Research, UNSW Sydney Sydney New South Wales Australia.<br /><searchLink fieldCode="AU" term="%22Evans+K%22">Evans K</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health UNSW Centre for Childhood Cancer Research, UNSW Sydney Sydney New South Wales Australia.<br /><searchLink fieldCode="AU" term="%22Kosasih+H%22">Kosasih H</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health UNSW Centre for Childhood Cancer Research, UNSW Sydney Sydney New South Wales Australia.<br /><searchLink fieldCode="AU" term="%22Mayoh+C%22">Mayoh C</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health UNSW Centre for Childhood Cancer Research, UNSW Sydney Sydney New South Wales Australia.<br /><searchLink fieldCode="AU" term="%22Erickson+SW%22">Erickson SW</searchLink>; RTI International, Research Triangle Park North Carolina USA.<br /><searchLink fieldCode="AU" term="%22Earley+EJ%22">Earley EJ</searchLink>; RTI International, Research Triangle Park North Carolina USA.<br /><searchLink fieldCode="AU" term="%22Neuhauser+S%22">Neuhauser S</searchLink>; The Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA.<br /><searchLink fieldCode="AU" term="%22Stearns+TM%22">Stearns TM</searchLink>; The Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA.<br /><searchLink fieldCode="AU" term="%22Philip+VM%22">Philip VM</searchLink>; The Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA.<br /><searchLink fieldCode="AU" term="%22Chuang+JH%22">Chuang JH</searchLink>; The Jackson Laboratory for Genomic Medicine Farmington Connecticut USA.<br /><searchLink fieldCode="AU" term="%22de+Bock+CE%22">de Bock CE</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health UNSW Centre for Childhood Cancer Research, UNSW Sydney Sydney New South Wales Australia.<br /><searchLink fieldCode="AU" term="%22Bowman+EP%22">Bowman EP</searchLink>; Department of Oncology Merck & Co. Inc. Rahway New Jersey USA.<br /><searchLink fieldCode="AU" term="%22Jessen+KA%22">Jessen KA</searchLink>; Formerly VelosBio Inc. San Diego California USA.<br /><searchLink fieldCode="AU" term="%22Jocoy+EL%22">Jocoy EL</searchLink>; The Jackson Laboratory Sacramento California USA.<br /><searchLink fieldCode="AU" term="%22Bult+CJ%22">Bult CJ</searchLink>; The Jackson Laboratory for Mammalian Genetics Bar Harbor Maine USA.<br /><searchLink fieldCode="AU" term="%22Teicher+BA%22">Teicher BA</searchLink>; National Cancer Institute Bethesda Maryland USA.<br /><searchLink fieldCode="AU" term="%22Smith+MA%22">Smith MA</searchLink>; National Cancer Institute Bethesda Maryland USA.<br /><searchLink fieldCode="AU" term="%22Lock+RB%22">Lock RB</searchLink>; Children's Cancer Institute, Lowy Cancer Research Centre, School of Clinical Medicine, UNSW Medicine & Health UNSW Centre for Childhood Cancer Research, UNSW Sydney Sydney New South Wales Australia.
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