Chinese prescription Kangen-karyu attenuates neuronal damage and improves cognitive function in global cerebral ischemia/reperfusion by regulating ROS-mediated MAPK activation.

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Title: Chinese prescription Kangen-karyu attenuates neuronal damage and improves cognitive function in global cerebral ischemia/reperfusion by regulating ROS-mediated MAPK activation.
Authors: Lee JH; Institute of New Frontier Research Team, Research Institute of Medical-Bio Convergence, Hallym University, Chuncheon, Republic of Korea., Kim JT; Institute of New Frontier Research Team, Research Institute of Medical-Bio Convergence, Hallym University, Chuncheon, Republic of Korea., Han SW; Institute of New Frontier Research Team, Research Institute of Medical-Bio Convergence, Hallym University, Chuncheon, Republic of Korea., Pak S; Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea., Lee S; Institute of New Frontier Research Team, Research Institute of Medical-Bio Convergence, Hallym University, Chuncheon, Republic of Korea., Cho Y; Institute of New Frontier Research Team, Research Institute of Medical-Bio Convergence, Hallym University, Chuncheon, Republic of Korea., Akimoto Y; Iskra Industry Co., Ltd., Chuo, Japan., Shoji M; Pharmacy of Kaikido, Yokohama, Japan., Zhang L; Iskra Industry Co., Ltd., Chuo, Japan., Song K; Bio and Health Photonics Research Center Korea Photonics Technology Institute, Cheonan, Republic of Korea., Choi HR; Bio and Health Photonics Research Center Korea Photonics Technology Institute, Cheonan, Republic of Korea., Han GS; Life Genomics Co., Ltd., Ressearch and Development Center, Suwon, Republic of Korea., Chung HY; Department of Pharmacy, College of Pharmacy, Pusan National University, Busan, Republic of Korea., Choi JS; Department of Food Science and Human Nutrition, Chongbuk National University, Jeonju, Republic of Korea., Lim JD; Department of Bio-Health Convergence, Kangwon National University, Chuncheon, Republic of Korea.; Convergence Program of Bio-pharmaceutical Engineering, Kangwon National University, Chuncheon, Republic of Korea., Jeon JP; Department of Neurosurgery, College of Medicine, Hallym University, Chuncheon, Republic of Korea., Park CH; Institute of New Frontier Research Team, Research Institute of Medical-Bio Convergence, Hallym University, Chuncheon, Republic of Korea.; Convergence Program of Bio-pharmaceutical Engineering, Kangwon National University, Chuncheon, Republic of Korea., Youn DH; Institute of New Frontier Research Team, Research Institute of Medical-Bio Convergence, Hallym University, Chuncheon, Republic of Korea.
Source: Frontiers in pharmacology [Front Pharmacol] 2026 Jul 08; Vol. 17, pp. 1860305. Date of Electronic Publication: 2026 Jul 08 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE
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  Data: Chinese prescription Kangen-karyu attenuates neuronal damage and improves cognitive function in global cerebral ischemia/reperfusion by regulating ROS-mediated MAPK activation.
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  Data: <searchLink fieldCode="AU" term="%22Lee+JH%22">Lee JH</searchLink>; Institute of New Frontier Research Team, Research Institute of Medical-Bio Convergence, Hallym University, Chuncheon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Kim+JT%22">Kim JT</searchLink>; Institute of New Frontier Research Team, Research Institute of Medical-Bio Convergence, Hallym University, Chuncheon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Han+SW%22">Han SW</searchLink>; Institute of New Frontier Research Team, Research Institute of Medical-Bio Convergence, Hallym University, Chuncheon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Pak+S%22">Pak S</searchLink>; Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lee+S%22">Lee S</searchLink>; Institute of New Frontier Research Team, Research Institute of Medical-Bio Convergence, Hallym University, Chuncheon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Cho+Y%22">Cho Y</searchLink>; Institute of New Frontier Research Team, Research Institute of Medical-Bio Convergence, Hallym University, Chuncheon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Akimoto+Y%22">Akimoto Y</searchLink>; Iskra Industry Co., Ltd., Chuo, Japan.<br /><searchLink fieldCode="AU" term="%22Shoji+M%22">Shoji M</searchLink>; Pharmacy of Kaikido, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Iskra Industry Co., Ltd., Chuo, Japan.<br /><searchLink fieldCode="AU" term="%22Song+K%22">Song K</searchLink>; Bio and Health Photonics Research Center Korea Photonics Technology Institute, Cheonan, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Choi+HR%22">Choi HR</searchLink>; Bio and Health Photonics Research Center Korea Photonics Technology Institute, Cheonan, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Han+GS%22">Han GS</searchLink>; Life Genomics Co., Ltd., Ressearch and Development Center, Suwon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Chung+HY%22">Chung HY</searchLink>; Department of Pharmacy, College of Pharmacy, Pusan National University, Busan, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Choi+JS%22">Choi JS</searchLink>; Department of Food Science and Human Nutrition, Chongbuk National University, Jeonju, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Lim+JD%22">Lim JD</searchLink>; Department of Bio-Health Convergence, Kangwon National University, Chuncheon, Republic of Korea.; Convergence Program of Bio-pharmaceutical Engineering, Kangwon National University, Chuncheon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Jeon+JP%22">Jeon JP</searchLink>; Department of Neurosurgery, College of Medicine, Hallym University, Chuncheon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Park+CH%22">Park CH</searchLink>; Institute of New Frontier Research Team, Research Institute of Medical-Bio Convergence, Hallym University, Chuncheon, Republic of Korea.; Convergence Program of Bio-pharmaceutical Engineering, Kangwon National University, Chuncheon, Republic of Korea.<br /><searchLink fieldCode="AU" term="%22Youn+DH%22">Youn DH</searchLink>; Institute of New Frontier Research Team, Research Institute of Medical-Bio Convergence, Hallym University, Chuncheon, Republic of Korea.
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  Data: <searchLink fieldCode="JN" term="%22101548923%22">Frontiers in pharmacology</searchLink> [Front Pharmacol] 2026 Jul 08; Vol. 17, pp. 1860305. <i>Date of Electronic Publication: </i>2026 Jul 08 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Media]%22">Frontiers Media] </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101548923 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>1663-9812 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216639812%22">16639812 </searchLink><i>NLM ISO Abbreviation: </i>Front Pharmacol <i>Subsets: </i>PubMed not MEDLINE
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              Text: 2026 Jul 08
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