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CAR-T cell signaling dynamics, rational design principles and artificial intelligence for next-generation chimeric antigen receptors.

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Title: CAR-T cell signaling dynamics, rational design principles and artificial intelligence for next-generation chimeric antigen receptors.
Authors: Liu X; Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States., Tong F; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States., Zhang J; Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States., Gradishar W; Division of Hematology and Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States., Liu H; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.; Division of Hematology and Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.; Biohub, Chicago, IL, United States., Wang R; Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.; Department of Pediatrics, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
Source: Frontiers in immunology [Front Immunol] 2026 Jul 08; Vol. 17, pp. 1893076. Date of Electronic Publication: 2026 Jul 08 (Print Publication: 2026).
Publication Type: Journal Article; Review
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.<br /><searchLink fieldCode="AU" term="%22Tong+F%22">Tong F</searchLink>; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.<br /><searchLink fieldCode="AU" term="%22Gradishar+W%22">Gradishar W</searchLink>; Division of Hematology and Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.<br /><searchLink fieldCode="AU" term="%22Liu+H%22">Liu H</searchLink>; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.; Division of Hematology and Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.; Biohub, Chicago, IL, United States.<br /><searchLink fieldCode="AU" term="%22Wang+R%22">Wang R</searchLink>; Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.; Department of Pediatrics, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
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  Data: <searchLink fieldCode="JN" term="%22101560960%22">Frontiers in immunology</searchLink> [Front Immunol] 2026 Jul 08; Vol. 17, pp. 1893076. <i>Date of Electronic Publication: </i>2026 Jul 08 (<i>Print Publication: </i>2026).
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        Value: 10.3389/fimmu.2026.1893076
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              Text: 2026 Jul 08
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