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Sirexatamab in Combination with Bevacizumab and Chemotherapy as Second-Line Therapy for Advanced Colorectal Adenocarcinoma: the Phase II DeFianCe Trial.

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Title: Sirexatamab in Combination with Bevacizumab and Chemotherapy as Second-Line Therapy for Advanced Colorectal Adenocarcinoma: the Phase II DeFianCe Trial.
Authors: Wainberg ZA; University of California, Los Angeles Los Angeles, CA United States., Lee KW; Seoul National University Bundang Hospital Seongnam, Gyeongi Korea (South), Republic of., Kim JG; Kyungpook National University Chilgok Hospital Daegu Korea (South), Republic of., Devoe C; Zucker School of Medicine at Hofstra/Northwell Lake Success, NY United States., Strickler JH; Duke University Durham, NC United States., Baum J; Leap Therapeutics Cambridge, MA United States., Jia C; Leap Therapeutics, Inc. (United States)., Kagey MH; Leap Therapeutics, Inc. (United States)., Sirard CA; Leap Therapeutics, Inc. (United States)., Stein A; University Medical Center Hamburg-Eppendorf Hamburg, Hamburg Germany., Scott AJ; Banner University of Arizona Cancer Center Tucson, AZ United States., Pelster M; Tennessee Oncology Nashville, Tennessee United States., Moehler M; University of Mainz Mainz Germany., Han SW; Seoul National University Hospital Seoul Korea (South), Republic of.
Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2026 Jul 23. Date of Electronic Publication: 2026 Jul 23.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Sirexatamab in Combination with Bevacizumab and Chemotherapy as Second-Line Therapy for Advanced Colorectal Adenocarcinoma: the Phase II DeFianCe Trial.
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  Data: <searchLink fieldCode="AU" term="%22Wainberg+ZA%22">Wainberg ZA</searchLink>; University of California, Los Angeles Los Angeles, CA United States.<br /><searchLink fieldCode="AU" term="%22Lee+KW%22">Lee KW</searchLink>; Seoul National University Bundang Hospital Seongnam, Gyeongi Korea (South), Republic of.<br /><searchLink fieldCode="AU" term="%22Kim+JG%22">Kim JG</searchLink>; Kyungpook National University Chilgok Hospital Daegu Korea (South), Republic of.<br /><searchLink fieldCode="AU" term="%22Devoe+C%22">Devoe C</searchLink>; Zucker School of Medicine at Hofstra/Northwell Lake Success, NY United States.<br /><searchLink fieldCode="AU" term="%22Strickler+JH%22">Strickler JH</searchLink>; Duke University Durham, NC United States.<br /><searchLink fieldCode="AU" term="%22Baum+J%22">Baum J</searchLink>; Leap Therapeutics Cambridge, MA United States.<br /><searchLink fieldCode="AU" term="%22Jia+C%22">Jia C</searchLink>; Leap Therapeutics, Inc. (United States).<br /><searchLink fieldCode="AU" term="%22Kagey+MH%22">Kagey MH</searchLink>; Leap Therapeutics, Inc. (United States).<br /><searchLink fieldCode="AU" term="%22Sirard+CA%22">Sirard CA</searchLink>; Leap Therapeutics, Inc. (United States).<br /><searchLink fieldCode="AU" term="%22Stein+A%22">Stein A</searchLink>; University Medical Center Hamburg-Eppendorf Hamburg, Hamburg Germany.<br /><searchLink fieldCode="AU" term="%22Scott+AJ%22">Scott AJ</searchLink>; Banner University of Arizona Cancer Center Tucson, AZ United States.<br /><searchLink fieldCode="AU" term="%22Pelster+M%22">Pelster M</searchLink>; Tennessee Oncology Nashville, Tennessee United States.<br /><searchLink fieldCode="AU" term="%22Moehler+M%22">Moehler M</searchLink>; University of Mainz Mainz Germany.<br /><searchLink fieldCode="AU" term="%22Han+SW%22">Han SW</searchLink>; Seoul National University Hospital Seoul Korea (South), Republic of.
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  Data: <searchLink fieldCode="JN" term="%229502500%22">Clinical cancer research : an official journal of the American Association for Cancer Research</searchLink> [Clin Cancer Res] 2026 Jul 23. <i>Date of Electronic Publication: </i>2026 Jul 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9502500 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1557-3265 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210780432%22">10780432 </searchLink><i>NLM ISO Abbreviation: </i>Clin Cancer Res <i>Subsets: </i>MEDLINE
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        Value: 10.1158/1078-0432.CCR-26-1456
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              Text: 2026 Jul 23
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