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From synaptic development to degeneration: a narrative review of small molecule strategies targeting alpha-synuclein in Parkinson's disease.

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Title: From synaptic development to degeneration: a narrative review of small molecule strategies targeting alpha-synuclein in Parkinson's disease.
Authors: Khoo L; School of Health Science, IMU University, Kuala Lumpur, 57000, Malaysia., Ng KY; School of Pharmacy, Monash University Malaysia, Selangor, 47500, Malaysia., Chye CL; School of Medicine, I-Shou University, Kaohsiung, 824, Taiwan.; Kaohsiung, 824, Taiwan., Ko Y; Department of medicine, Lyell McEwin Hospital, Adelaide, 5112, Australia., Lee JY; School of Health Science, IMU University, Kuala Lumpur, 57000, Malaysia., Koh Y; School of Health Science, Division of Applied Biomedical Science and Biotechnology, IMU University, No. 126, Jalan Jalil Perkasa 19, Bukit Jalil, Kuala Lumpur, 57000, Malaysia., Tsen MT; School of Health Science, Division of Applied Biomedical Science and Biotechnology, IMU University, No. 126, Jalan Jalil Perkasa 19, Bukit Jalil, Kuala Lumpur, 57000, Malaysia., Chye SM; School of Health Science, Division of Applied Biomedical Science and Biotechnology, IMU University, No. 126, Jalan Jalil Perkasa 19, Bukit Jalil, Kuala Lumpur, 57000, Malaysia. chye_soimoi@imu.edu.my.
Source: Metabolic brain disease [Metab Brain Dis] 2026 Jul 23; Vol. 41 (1). Date of Electronic Publication: 2026 Jul 23.
Publication Type: Journal Article; Review
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 8610370 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-7365 (Electronic) Linking ISSN: 08857490 NLM ISO Abbreviation: Metab Brain Dis Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: From synaptic development to degeneration: a narrative review of small molecule strategies targeting alpha-synuclein in Parkinson's disease.
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  Data: <searchLink fieldCode="AU" term="%22Khoo+L%22">Khoo L</searchLink>; School of Health Science, IMU University, Kuala Lumpur, 57000, Malaysia.<br /><searchLink fieldCode="AU" term="%22Ng+KY%22">Ng KY</searchLink>; School of Pharmacy, Monash University Malaysia, Selangor, 47500, Malaysia.<br /><searchLink fieldCode="AU" term="%22Chye+CL%22">Chye CL</searchLink>; School of Medicine, I-Shou University, Kaohsiung, 824, Taiwan.; Kaohsiung, 824, Taiwan.<br /><searchLink fieldCode="AU" term="%22Ko+Y%22">Ko Y</searchLink>; Department of medicine, Lyell McEwin Hospital, Adelaide, 5112, Australia.<br /><searchLink fieldCode="AU" term="%22Lee+JY%22">Lee JY</searchLink>; School of Health Science, IMU University, Kuala Lumpur, 57000, Malaysia.<br /><searchLink fieldCode="AU" term="%22Koh+Y%22">Koh Y</searchLink>; School of Health Science, Division of Applied Biomedical Science and Biotechnology, IMU University, No. 126, Jalan Jalil Perkasa 19, Bukit Jalil, Kuala Lumpur, 57000, Malaysia.<br /><searchLink fieldCode="AU" term="%22Tsen+MT%22">Tsen MT</searchLink>; School of Health Science, Division of Applied Biomedical Science and Biotechnology, IMU University, No. 126, Jalan Jalil Perkasa 19, Bukit Jalil, Kuala Lumpur, 57000, Malaysia.<br /><searchLink fieldCode="AU" term="%22Chye+SM%22">Chye SM</searchLink>; School of Health Science, Division of Applied Biomedical Science and Biotechnology, IMU University, No. 126, Jalan Jalil Perkasa 19, Bukit Jalil, Kuala Lumpur, 57000, Malaysia. chye_soimoi@imu.edu.my.
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  Data: <searchLink fieldCode="JN" term="%228610370%22">Metabolic brain disease</searchLink> [Metab Brain Dis] 2026 Jul 23; Vol. 41 (1). <i>Date of Electronic Publication: </i>2026 Jul 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8610370 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1573-7365 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2208857490%22">08857490 </searchLink><i>NLM ISO Abbreviation: </i>Metab Brain Dis <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s11011-026-01911-y
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        Text: English
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      – TitleFull: From synaptic development to degeneration: a narrative review of small molecule strategies targeting alpha-synuclein in Parkinson's disease.
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              Text: 2026 Jul 23
              Type: published
              Y: 2026
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