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LY3410738, a Covalent Inhibitor of Mutant IDH1/2, is Effective in Acute Myeloid Leukemia Preclinical Models.

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Title: LY3410738, a Covalent Inhibitor of Mutant IDH1/2, is Effective in Acute Myeloid Leukemia Preclinical Models.
Authors: Brooks NA; Eli Lilly (United States) Indianapolis, IN United States., Skwarska A; Albert Einstein College of Medicine Bronx, New York United States., Salama V; West Virginia University Morgantown, WV United States., Bender MH; Eli Lilly and Company Indianapolis, IN United States., Kays L; Eli Lilly and Company Indianapolis, IN United States., DeWalt RI; Arvinas (United States) New Haven, CT United States., Perria B; Eli Lilly (United States) Indianapolis, IN United States., Thete D; Eli Lilly (United States) United States., Manro JR; Eli Lilly and Company Indianapolis, IN United States., Cavitt R; Eli Lilly (United States) Indianapolis, IN United States., Leon R; Eli Lilly and Company Indianapolis, IN United States., Gomez S; Eli Lilly (Spain) Alcobendas, Madrid, Spain Spain., Torres R; Eli Lilly and Company Alcobendas Spain., Strelow JM; Eli Lilly and Company United States., Milligan P; Eli Lilly and Company Indianapolis, IN United States., Newell K; Eli Lilly and Company Indianapolis, IN United States., Roth KD; Eli Lilly (United States) Indianapolis, IN United States., Sarry JE; Inserm and Universite de Toulouse Toulouse France., Chan SM; Princess Margaret Cancer Centre Toronto Canada., Lagutan DM; Eli Lilly and Company San DIego, CA United States., Romero R; Eli Lilly (United States) San Diego, Ca United States., Antonysamy S; Eli Lilly (United States) Indianapolis, IN United States., Johnson RL; Eli Lilly and Company Indianapolis, IN United States., Gong X; Eli Lilly and Company Indianapolis, Indiana United States., Bauer RA; Eli Lilly and Company Indianapolis, IN United States., Burkholder TP; Eli Lilly and Company Indianapolis, IN United States., Hahn PJ; Eli Lilly and Company Indianapolis, IN United States., Rankovic Z; Institute of Cancer Research Sutton United Kingdom., Boulet SL; Eli Lilly and Company United States., DiNardo CD; The University of Texas MD Anderson Cancer Center Houston, TX United States., Konopleva M; Albert Einstein College of Medicine Bronx, New York United States., Gilmour R; Eli Lilly (United States) Indianapolis, IN United States.
Source: Blood cancer discovery [Blood Cancer Discov] 2026 Jul 23. Date of Electronic Publication: 2026 Jul 23.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101764786 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2643-3249 (Electronic) Linking ISSN: 26433230 NLM ISO Abbreviation: Blood Cancer Discov Subsets: MEDLINE
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101764786 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2643-3249 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226433230%22">26433230 </searchLink><i>NLM ISO Abbreviation: </i>Blood Cancer Discov <i>Subsets: </i>MEDLINE
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        Value: 10.1158/2643-3230.BCD-25-0379
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        Text: English
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