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Single-cell multiomics connects 3D genome and transcriptome alterations in Alzheimer's disease.

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Title: Single-cell multiomics connects 3D genome and transcriptome alterations in Alzheimer's disease.
Authors: Zhang Y; Ray and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA., Lu X; Ray and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA., Kunisky AK; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA., Alam S; Ray and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA., Tang J; Ray and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA., Zhang R; Eric and Wendy Schmidt Center, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Wang S; Ray and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA., Zhang H; Computer Science Department, University of California, Los Angeles, Los Angeles, CA, USA., Baroudi J; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA., Ichcho W; Division of Hematology and Oncology, Department of Medicine, University of Washington, Seattle, WA, USA., Jia D; Department of Urology, University of Washington, Seattle, WA, USA., Ghorbanikalateh S; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA., Ghorbanikalateh S; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA., Wang S; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA., Bennett DA; Rush Alzheimer's Disease Center, Chicago, IL, USA., Mathys H; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA., Duan Z; Division of Hematology and Oncology, Department of Medicine, University of Washington, Seattle, WA, USA.; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA.; Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Ma J; Ray and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA.
Source: Science (New York, N.Y.) [Science] 2026 Jul 23; Vol. 393 (6809), pp. eadz1652. Date of Electronic Publication: 2026 Jul 23.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Single-cell multiomics connects 3D genome and transcriptome alterations in Alzheimer's disease.
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  Data: <searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Ray and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Lu+X%22">Lu X</searchLink>; Ray and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Kunisky+AK%22">Kunisky AK</searchLink>; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Alam+S%22">Alam S</searchLink>; Ray and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Tang+J%22">Tang J</searchLink>; Ray and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+R%22">Zhang R</searchLink>; Eric and Wendy Schmidt Center, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Ray and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Computer Science Department, University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Baroudi+J%22">Baroudi J</searchLink>; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Ichcho+W%22">Ichcho W</searchLink>; Division of Hematology and Oncology, Department of Medicine, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Jia+D%22">Jia D</searchLink>; Department of Urology, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Ghorbanikalateh+S%22">Ghorbanikalateh S</searchLink>; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Ghorbanikalateh+S%22">Ghorbanikalateh S</searchLink>; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Bennett+DA%22">Bennett DA</searchLink>; Rush Alzheimer's Disease Center, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Mathys+H%22">Mathys H</searchLink>; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Duan+Z%22">Duan Z</searchLink>; Division of Hematology and Oncology, Department of Medicine, University of Washington, Seattle, WA, USA.; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA.; Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Ma+J%22">Ma J</searchLink>; Ray and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA.
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