Single-cell multiomics connects 3D genome and transcriptome alterations in Alzheimer's disease.

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Title: Single-cell multiomics connects 3D genome and transcriptome alterations in Alzheimer's disease.
Authors: Zhang Y; Ray and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA., Lu X; Ray and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA., Kunisky AK; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA., Alam S; Ray and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA., Tang J; Ray and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA., Zhang R; Eric and Wendy Schmidt Center, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Wang S; Ray and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA., Zhang H; Computer Science Department, University of California, Los Angeles, Los Angeles, CA, USA., Baroudi J; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA., Ichcho W; Division of Hematology and Oncology, Department of Medicine, University of Washington, Seattle, WA, USA., Jia D; Department of Urology, University of Washington, Seattle, WA, USA., Ghorbanikalateh S; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA., Ghorbanikalateh S; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA., Wang S; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA., Bennett DA; Rush Alzheimer's Disease Center, Chicago, IL, USA., Mathys H; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA., Duan Z; Division of Hematology and Oncology, Department of Medicine, University of Washington, Seattle, WA, USA.; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA.; Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, USA., Ma J; Ray and Stephanie Lane Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA.
Source: Science (New York, N.Y.) [Science] 2026 Jul 23; Vol. 393 (6809), pp. eadz1652. Date of Electronic Publication: 2026 Jul 23.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1095-9203
DOI:10.1126/science.adz1652