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Beyond pain response: rethinking endpoints in radiotherapy trials for bone metastases.

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Title: Beyond pain response: rethinking endpoints in radiotherapy trials for bone metastases.
Authors: Lee SF; Department of Radiation Oncology, National University Cancer Institute, National University Hospital, Singapore, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. Electronic address: leesf@nuhs.edu.sg., Wong HCY; Department of Oncology, Princess Margaret Hospital, Kowloon West Cluster, Hospital Authority, Hong Kong, China., Oldenburger E; Department of Radiation Oncology, Leiden University Medical Centre, Leiden, the Netherlands., Raman S; Department of Radiation Oncology, BC Cancer - Vancouver, Vancouver, Canada., Marta GN; Department of Radiation Oncology, Hospital Sírio-Libanês, São Paulo, Brazil; Latin America Cooperative Oncology Group, Porto Alegre, Brazil; Postgraduate Program. Department of Radiology and Oncology. Faculty of Medicine at University of São Paulo, São Paulo, Brazil., Chan AW; Department of Radiation Oncology, BC Cancer - Vancouver, Vancouver, Canada., Rades D; Department of Radiation Oncology, University of Lubeck, Lubeck, Germany., van der Linden YM; Department of Radiation Oncology, Leiden University Medical Centre, Leiden, the Netherlands; Centre of Expertise in Palliative Care, Leiden University Medical Centre, Leiden, the Netherlands., van der Velden JM; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands., Nguyen QN; Department of Radiation Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA., Isabelle Choi J; Department of Radiation Oncology, New York Proton Center, New York, NY, USA; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Hircock C; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada., Doccioli C; Clinical Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy., Cosma C; Department of Health Sciences, University of Florence, Florence, Italy., Caini S; Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy., Rembielak A; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, United Kingdom; Department of Clinical Oncology, Christie NHS Foundation Trust, Manchester, United Kingdom., Vassiliou V; Department of Radiation Oncology, Bank of Cyprus Oncology Centre, Nicosia, Cyprus., Bonomo P; Department of Radiation Oncology, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy., Alcorn SR; Department of Radiation Oncology, University of Minnesota Medical Center, Minneapolis, MN, USA., Johnstone C; Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA., Simone CB 2nd; Department of Radiation Oncology, New York Proton Center, New York, NY, USA; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Chao M; Olivia Newton John Cancer Wellness and Research Centre, Austin Hospital, Heidelberg, Victoria, Australia; Department of Medical Imaging and Radiation Sciences, School of Primary and Allied Health Care, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia; GenesisCare Victoria, Ringwood Private Hospital, Ringwood East, Melbourne, Victoria, Australia; University of Melbourne, Melbourne, Victoria, Australia., Saito T; Division of Integrative Medical Oncology, Saiseikai Kumamoto Hospital, Kumamoto, Japan; Department of Radiation Oncology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan., Hoskin PJ; Mount Vernon Cancer Centre, Northwood, United Kingdom; Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom., Chow E; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada; Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada., Ryu S; Department of Radiation Oncology, Stony Brook University Hospital, New York, NY, USA.
Source: European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2026 Jul 19; Vol. 245, pp. 116946. Date of Electronic Publication: 2026 Jul 19.
Publication Type: Editorial
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9005373 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0852 (Electronic) Linking ISSN: 09598049 NLM ISO Abbreviation: Eur J Cancer Subsets: MEDLINE
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  Data: Beyond pain response: rethinking endpoints in radiotherapy trials for bone metastases.
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  Data: <searchLink fieldCode="AU" term="%22Lee+SF%22">Lee SF</searchLink>; Department of Radiation Oncology, National University Cancer Institute, National University Hospital, Singapore, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. Electronic address: leesf@nuhs.edu.sg.<br /><searchLink fieldCode="AU" term="%22Wong+HCY%22">Wong HCY</searchLink>; Department of Oncology, Princess Margaret Hospital, Kowloon West Cluster, Hospital Authority, Hong Kong, China.<br /><searchLink fieldCode="AU" term="%22Oldenburger+E%22">Oldenburger E</searchLink>; Department of Radiation Oncology, Leiden University Medical Centre, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Raman+S%22">Raman S</searchLink>; Department of Radiation Oncology, BC Cancer - Vancouver, Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Marta+GN%22">Marta GN</searchLink>; Department of Radiation Oncology, Hospital Sírio-Libanês, São Paulo, Brazil; Latin America Cooperative Oncology Group, Porto Alegre, Brazil; Postgraduate Program. Department of Radiology and Oncology. Faculty of Medicine at University of São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Chan+AW%22">Chan AW</searchLink>; Department of Radiation Oncology, BC Cancer - Vancouver, Vancouver, Canada.<br /><searchLink fieldCode="AU" term="%22Rades+D%22">Rades D</searchLink>; Department of Radiation Oncology, University of Lubeck, Lubeck, Germany.<br /><searchLink fieldCode="AU" term="%22van+der+Linden+YM%22">van der Linden YM</searchLink>; Department of Radiation Oncology, Leiden University Medical Centre, Leiden, the Netherlands; Centre of Expertise in Palliative Care, Leiden University Medical Centre, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Velden+JM%22">van der Velden JM</searchLink>; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Nguyen+QN%22">Nguyen QN</searchLink>; Department of Radiation Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Isabelle+Choi+J%22">Isabelle Choi J</searchLink>; Department of Radiation Oncology, New York Proton Center, New York, NY, USA; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Hircock+C%22">Hircock C</searchLink>; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Doccioli+C%22">Doccioli C</searchLink>; Clinical Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Cosma+C%22">Cosma C</searchLink>; Department of Health Sciences, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Caini+S%22">Caini S</searchLink>; Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Rembielak+A%22">Rembielak A</searchLink>; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, United Kingdom; Department of Clinical Oncology, Christie NHS Foundation Trust, Manchester, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Vassiliou+V%22">Vassiliou V</searchLink>; Department of Radiation Oncology, Bank of Cyprus Oncology Centre, Nicosia, Cyprus.<br /><searchLink fieldCode="AU" term="%22Bonomo+P%22">Bonomo P</searchLink>; Department of Radiation Oncology, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Alcorn+SR%22">Alcorn SR</searchLink>; Department of Radiation Oncology, University of Minnesota Medical Center, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Johnstone+C%22">Johnstone C</searchLink>; Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.<br /><searchLink fieldCode="AU" term="%22Simone+CB+2nd%22">Simone CB 2nd</searchLink>; Department of Radiation Oncology, New York Proton Center, New York, NY, USA; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Chao+M%22">Chao M</searchLink>; Olivia Newton John Cancer Wellness and Research Centre, Austin Hospital, Heidelberg, Victoria, Australia; Department of Medical Imaging and Radiation Sciences, School of Primary and Allied Health Care, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia; GenesisCare Victoria, Ringwood Private Hospital, Ringwood East, Melbourne, Victoria, Australia; University of Melbourne, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Saito+T%22">Saito T</searchLink>; Division of Integrative Medical Oncology, Saiseikai Kumamoto Hospital, Kumamoto, Japan; Department of Radiation Oncology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.<br /><searchLink fieldCode="AU" term="%22Hoskin+PJ%22">Hoskin PJ</searchLink>; Mount Vernon Cancer Centre, Northwood, United Kingdom; Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Chow+E%22">Chow E</searchLink>; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada; Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.<br /><searchLink fieldCode="AU" term="%22Ryu+S%22">Ryu S</searchLink>; Department of Radiation Oncology, Stony Brook University Hospital, New York, NY, USA.
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  Data: <searchLink fieldCode="JN" term="%229005373%22">European journal of cancer (Oxford, England : 1990)</searchLink> [Eur J Cancer] 2026 Jul 19; Vol. 245, pp. 116946. <i>Date of Electronic Publication: </i>2026 Jul 19.
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