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Mefenamic acid attenuates NLRP3-associated neuroinflammation and mitochondrial dysfunction and is associated with prevention of long-term cognitive impairment after sepsis.

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Title: Mefenamic acid attenuates NLRP3-associated neuroinflammation and mitochondrial dysfunction and is associated with prevention of long-term cognitive impairment after sepsis.
Authors: Dominguini D; Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma 88806-000, SC, Brazil., Córneo E; Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma 88806-000, SC, Brazil., Simon CS; Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma 88806-000, SC, Brazil., da Costa Borges G; Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma 88806-000, SC, Brazil., Muller MMF; Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma 88806-000, SC, Brazil., Bortoluzzi DP; Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma 88806-000, SC, Brazil., Fagundes BMK; Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma 88806-000, SC, Brazil., Lemos I; Graduate Program in Public Health University of Southern Santa Catarina (UNESC), Criciúma 88806-000, SC, Brazil., Ceretta LB; Graduate Program in Public Health University of Southern Santa Catarina (UNESC), Criciúma 88806-000, SC, Brazil., Streck EL; Laboratory of Bioenergetics, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma 88806-000, SC, Brazil., Barichello T; Translational Psychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77054, USA., Ritter C; Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma 88806-000, SC, Brazil., Dal-Pizzol F; Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma 88806-000, SC, Brazil. Electronic address: piz@unesc.net.
Source: Journal of neuroimmunology [J Neuroimmunol] 2026 Jul 17; Vol. 420, pp. 579036. Date of Electronic Publication: 2026 Jul 17.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 8109498 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8421 (Electronic) Linking ISSN: 01655728 NLM ISO Abbreviation: J Neuroimmunol Subsets: MEDLINE
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  Data: Mefenamic acid attenuates NLRP3-associated neuroinflammation and mitochondrial dysfunction and is associated with prevention of long-term cognitive impairment after sepsis.
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  Data: <searchLink fieldCode="AU" term="%22Dominguini+D%22">Dominguini D</searchLink>; Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma 88806-000, SC, Brazil.<br /><searchLink fieldCode="AU" term="%22Córneo+E%22">Córneo E</searchLink>; Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma 88806-000, SC, Brazil.<br /><searchLink fieldCode="AU" term="%22Simon+CS%22">Simon CS</searchLink>; Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma 88806-000, SC, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Costa+Borges+G%22">da Costa Borges G</searchLink>; Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma 88806-000, SC, Brazil.<br /><searchLink fieldCode="AU" term="%22Muller+MMF%22">Muller MMF</searchLink>; Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma 88806-000, SC, Brazil.<br /><searchLink fieldCode="AU" term="%22Bortoluzzi+DP%22">Bortoluzzi DP</searchLink>; Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma 88806-000, SC, Brazil.<br /><searchLink fieldCode="AU" term="%22Fagundes+BMK%22">Fagundes BMK</searchLink>; Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma 88806-000, SC, Brazil.<br /><searchLink fieldCode="AU" term="%22Lemos+I%22">Lemos I</searchLink>; Graduate Program in Public Health University of Southern Santa Catarina (UNESC), Criciúma 88806-000, SC, Brazil.<br /><searchLink fieldCode="AU" term="%22Ceretta+LB%22">Ceretta LB</searchLink>; Graduate Program in Public Health University of Southern Santa Catarina (UNESC), Criciúma 88806-000, SC, Brazil.<br /><searchLink fieldCode="AU" term="%22Streck+EL%22">Streck EL</searchLink>; Laboratory of Bioenergetics, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma 88806-000, SC, Brazil.<br /><searchLink fieldCode="AU" term="%22Barichello+T%22">Barichello T</searchLink>; Translational Psychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77054, USA.<br /><searchLink fieldCode="AU" term="%22Ritter+C%22">Ritter C</searchLink>; Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma 88806-000, SC, Brazil.<br /><searchLink fieldCode="AU" term="%22Dal-Pizzol+F%22">Dal-Pizzol F</searchLink>; Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, University of Southern Santa Catarina (UNESC), Criciúma 88806-000, SC, Brazil. Electronic address: piz@unesc.net.
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