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Oral step-down, optimal drug, and total duration of antibiotic treatment in African children hospitalised with severe community-acquired pneumonia (PediCAP): a factorial randomised controlled trial.

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Title: Oral step-down, optimal drug, and total duration of antibiotic treatment in African children hospitalised with severe community-acquired pneumonia (PediCAP): a factorial randomised controlled trial.
Authors: Bielicki JA; Centre for Neonatal and Paediatric Infection, City St George's, University of London, London, UK. Electronic address: jbielick@citystgeorges.ac.uk., Clements M; University College London Innovative Clinical Trials Unit, University College London, London, UK., Musiime V; Department of Paediatrics and Child Health, Makerere University Kampala, Kampala, Uganda; Research Department, Joint Clinical Research Centre, Kampala, Uganda., Moore DP; South Africa Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Science, University of the Witwatersrand, Johannesburg, South Africa; Department of Paediatrics and Child Health, Chris Hani Baragwanath Academic Hospital, University of the Witwatersrand, Johannesburg, South Africa., Sidat M; Universidade Eduardo Mondlane, Faculdade de Medicina, Maputo, Mozambique., Mulenga V; University Teaching Hospitals-Children's Hospital, Lusaka, Zambia; School of Medicine, University of Zambia, Lusaka, Zambia., Mutata C; Clinical Research Centre, Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe., Nalwanga D; Department of Paediatrics and Child Health, Makerere University Kampala, Kampala, Uganda., Waggie Z; Department of Paediatrics and Child Health, Chris Hani Baragwanath Academic Hospital, University of the Witwatersrand, Johannesburg, South Africa., Chilundo J; Hospital Central de Maputo, Maputo, Mozambique., Chabala C; University Teaching Hospitals-Children's Hospital, Lusaka, Zambia; School of Medicine, University of Zambia, Lusaka, Zambia., Bwakura-Dangarembizi M; Clinical Research Centre, Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe., Archary M; Africa Health Research Institute, Victoria Mxenge Hospital, Durban, South Africa., Kiggwe A; China-Uganda Friendship Hospital Naguru, Kampala, Uganda., Dangor Z; South Africa Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Science, University of the Witwatersrand, Johannesburg, South Africa., Spittle B; University College London Innovative Clinical Trials Unit, University College London, London, UK., Kapasa M; University Teaching Hospitals-Children's Hospital, Lusaka, Zambia., Tagoola A; Jinja Regional Referral Hospital, Jinja, Uganda., Jeki C; Chitungwiza Central Hospital, Chitungwiza, Zimbabwe., Sacarlal J; Universidade Eduardo Mondlane, Faculdade de Medicina, Maputo, Mozambique., Buck WC; Universidade Eduardo Mondlane, Faculdade de Medicina, Maputo, Mozambique; University of California Los Angeles David Geffen School of Medicine, Los Angeles, CA, USA., Chanda S; Chawama General Hospital, Ministry of Health, Lusaka, Zambia., Mujuru HA; Clinical Research Centre, Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe., Giaquinto C; Department for Women's and Child Health, University of Padova, Padua, Italy; Penta Foundation, Padova, Italy., Madhi SA; South Africa Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Science, University of the Witwatersrand, Johannesburg, South Africa., Walker AS; University College London Innovative Clinical Trials Unit, University College London, London, UK., Sharland M; Centre for Neonatal and Paediatric Infection, City St George's, University of London, London, UK.
Corporate Authors: PediCAP trial team
Source: Lancet (London, England) [Lancet] 2026 Jul 23. Date of Electronic Publication: 2026 Jul 23.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 2985213R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-547X (Electronic) Linking ISSN: 01406736 NLM ISO Abbreviation: Lancet Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Oral step-down, optimal drug, and total duration of antibiotic treatment in African children hospitalised with severe community-acquired pneumonia (PediCAP): a factorial randomised controlled trial.
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  Data: <searchLink fieldCode="AU" term="%22Bielicki+JA%22">Bielicki JA</searchLink>; Centre for Neonatal and Paediatric Infection, City St George's, University of London, London, UK. Electronic address: jbielick@citystgeorges.ac.uk.<br /><searchLink fieldCode="AU" term="%22Clements+M%22">Clements M</searchLink>; University College London Innovative Clinical Trials Unit, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Musiime+V%22">Musiime V</searchLink>; Department of Paediatrics and Child Health, Makerere University Kampala, Kampala, Uganda; Research Department, Joint Clinical Research Centre, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Moore+DP%22">Moore DP</searchLink>; South Africa Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Science, University of the Witwatersrand, Johannesburg, South Africa; Department of Paediatrics and Child Health, Chris Hani Baragwanath Academic Hospital, University of the Witwatersrand, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Sidat+M%22">Sidat M</searchLink>; Universidade Eduardo Mondlane, Faculdade de Medicina, Maputo, Mozambique.<br /><searchLink fieldCode="AU" term="%22Mulenga+V%22">Mulenga V</searchLink>; University Teaching Hospitals-Children's Hospital, Lusaka, Zambia; School of Medicine, University of Zambia, Lusaka, Zambia.<br /><searchLink fieldCode="AU" term="%22Mutata+C%22">Mutata C</searchLink>; Clinical Research Centre, Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe.<br /><searchLink fieldCode="AU" term="%22Nalwanga+D%22">Nalwanga D</searchLink>; Department of Paediatrics and Child Health, Makerere University Kampala, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Waggie+Z%22">Waggie Z</searchLink>; Department of Paediatrics and Child Health, Chris Hani Baragwanath Academic Hospital, University of the Witwatersrand, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Chilundo+J%22">Chilundo J</searchLink>; Hospital Central de Maputo, Maputo, Mozambique.<br /><searchLink fieldCode="AU" term="%22Chabala+C%22">Chabala C</searchLink>; University Teaching Hospitals-Children's Hospital, Lusaka, Zambia; School of Medicine, University of Zambia, Lusaka, Zambia.<br /><searchLink fieldCode="AU" term="%22Bwakura-Dangarembizi+M%22">Bwakura-Dangarembizi M</searchLink>; Clinical Research Centre, Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe.<br /><searchLink fieldCode="AU" term="%22Archary+M%22">Archary M</searchLink>; Africa Health Research Institute, Victoria Mxenge Hospital, Durban, South Africa.<br /><searchLink fieldCode="AU" term="%22Kiggwe+A%22">Kiggwe A</searchLink>; China-Uganda Friendship Hospital Naguru, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Dangor+Z%22">Dangor Z</searchLink>; South Africa Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Science, University of the Witwatersrand, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Spittle+B%22">Spittle B</searchLink>; University College London Innovative Clinical Trials Unit, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Kapasa+M%22">Kapasa M</searchLink>; University Teaching Hospitals-Children's Hospital, Lusaka, Zambia.<br /><searchLink fieldCode="AU" term="%22Tagoola+A%22">Tagoola A</searchLink>; Jinja Regional Referral Hospital, Jinja, Uganda.<br /><searchLink fieldCode="AU" term="%22Jeki+C%22">Jeki C</searchLink>; Chitungwiza Central Hospital, Chitungwiza, Zimbabwe.<br /><searchLink fieldCode="AU" term="%22Sacarlal+J%22">Sacarlal J</searchLink>; Universidade Eduardo Mondlane, Faculdade de Medicina, Maputo, Mozambique.<br /><searchLink fieldCode="AU" term="%22Buck+WC%22">Buck WC</searchLink>; Universidade Eduardo Mondlane, Faculdade de Medicina, Maputo, Mozambique; University of California Los Angeles David Geffen School of Medicine, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chanda+S%22">Chanda S</searchLink>; Chawama General Hospital, Ministry of Health, Lusaka, Zambia.<br /><searchLink fieldCode="AU" term="%22Mujuru+HA%22">Mujuru HA</searchLink>; Clinical Research Centre, Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe.<br /><searchLink fieldCode="AU" term="%22Giaquinto+C%22">Giaquinto C</searchLink>; Department for Women's and Child Health, University of Padova, Padua, Italy; Penta Foundation, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Madhi+SA%22">Madhi SA</searchLink>; South Africa Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Science, University of the Witwatersrand, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Walker+AS%22">Walker AS</searchLink>; University College London Innovative Clinical Trials Unit, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Sharland+M%22">Sharland M</searchLink>; Centre for Neonatal and Paediatric Infection, City St George's, University of London, London, UK.
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  Data: <searchLink fieldCode="CA" term="%22PediCAP+trial+team%22">PediCAP trial team</searchLink>
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