Oral step-down, optimal drug, and total duration of antibiotic treatment in African children hospitalised with severe community-acquired pneumonia (PediCAP): a factorial randomised controlled trial.
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| Title: | Oral step-down, optimal drug, and total duration of antibiotic treatment in African children hospitalised with severe community-acquired pneumonia (PediCAP): a factorial randomised controlled trial. |
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| Authors: | Bielicki JA; Centre for Neonatal and Paediatric Infection, City St George's, University of London, London, UK. Electronic address: jbielick@citystgeorges.ac.uk., Clements M; University College London Innovative Clinical Trials Unit, University College London, London, UK., Musiime V; Department of Paediatrics and Child Health, Makerere University Kampala, Kampala, Uganda; Research Department, Joint Clinical Research Centre, Kampala, Uganda., Moore DP; South Africa Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Science, University of the Witwatersrand, Johannesburg, South Africa; Department of Paediatrics and Child Health, Chris Hani Baragwanath Academic Hospital, University of the Witwatersrand, Johannesburg, South Africa., Sidat M; Universidade Eduardo Mondlane, Faculdade de Medicina, Maputo, Mozambique., Mulenga V; University Teaching Hospitals-Children's Hospital, Lusaka, Zambia; School of Medicine, University of Zambia, Lusaka, Zambia., Mutata C; Clinical Research Centre, Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe., Nalwanga D; Department of Paediatrics and Child Health, Makerere University Kampala, Kampala, Uganda., Waggie Z; Department of Paediatrics and Child Health, Chris Hani Baragwanath Academic Hospital, University of the Witwatersrand, Johannesburg, South Africa., Chilundo J; Hospital Central de Maputo, Maputo, Mozambique., Chabala C; University Teaching Hospitals-Children's Hospital, Lusaka, Zambia; School of Medicine, University of Zambia, Lusaka, Zambia., Bwakura-Dangarembizi M; Clinical Research Centre, Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe., Archary M; Africa Health Research Institute, Victoria Mxenge Hospital, Durban, South Africa., Kiggwe A; China-Uganda Friendship Hospital Naguru, Kampala, Uganda., Dangor Z; South Africa Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Science, University of the Witwatersrand, Johannesburg, South Africa., Spittle B; University College London Innovative Clinical Trials Unit, University College London, London, UK., Kapasa M; University Teaching Hospitals-Children's Hospital, Lusaka, Zambia., Tagoola A; Jinja Regional Referral Hospital, Jinja, Uganda., Jeki C; Chitungwiza Central Hospital, Chitungwiza, Zimbabwe., Sacarlal J; Universidade Eduardo Mondlane, Faculdade de Medicina, Maputo, Mozambique., Buck WC; Universidade Eduardo Mondlane, Faculdade de Medicina, Maputo, Mozambique; University of California Los Angeles David Geffen School of Medicine, Los Angeles, CA, USA., Chanda S; Chawama General Hospital, Ministry of Health, Lusaka, Zambia., Mujuru HA; Clinical Research Centre, Faculty of Medicine and Health Sciences, University of Zimbabwe, Harare, Zimbabwe., Giaquinto C; Department for Women's and Child Health, University of Padova, Padua, Italy; Penta Foundation, Padova, Italy., Madhi SA; South Africa Medical Research Council Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Science, University of the Witwatersrand, Johannesburg, South Africa., Walker AS; University College London Innovative Clinical Trials Unit, University College London, London, UK., Sharland M; Centre for Neonatal and Paediatric Infection, City St George's, University of London, London, UK. |
| Corporate Authors: | PediCAP trial team |
| Source: | Lancet (London, England) [Lancet] 2026 Jul 23. Date of Electronic Publication: 2026 Jul 23. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Country of Publication: England NLM ID: 2985213R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-547X (Electronic) Linking ISSN: 01406736 NLM ISO Abbreviation: Lancet Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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