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Liquid Biopsy Cell-free RNA-based Machine Learning Enables Preoperative Risk-Stratification of Uterine Leiomyosarcoma.

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Title: Liquid Biopsy Cell-free RNA-based Machine Learning Enables Preoperative Risk-Stratification of Uterine Leiomyosarcoma.
Authors: Stahlschmidt SR; Carlos Simon Foundation, Valencia, Spain., Lago V; Department of Gynecologic Oncology University and Polytechnic Hospital La Fe, Valencia, Spain; Gynecological Tumours, Breast and Hereditary Cancer Research Group, La Fe Health Research Institute (IISLAFE), Valencia, Spain; CEU Cardenal Herrera University, Valencia, Spain., Machado-López A; Carlos Simon Foundation, Valencia, Spain; INCLIVA Health Research Institute, Valencia, Spain., Boldú-Fernández S; Carlos Simon Foundation, Valencia, Spain; INCLIVA Health Research Institute, Valencia, Spain., Lara E; Carlos Simon Foundation, Valencia, Spain., Gómez C; R&D Department, Igenomix SL, Paterna, Valencia, Spain., Valbuena D; R&D Department, Igenomix SL, Paterna, Valencia, Spain., Amadoz A; R&D Department, Igenomix SL, Paterna, Valencia, Spain., Jiménez-Almazan J; R&D Department, Igenomix SL, Paterna, Valencia, Spain., Montero B; Department of Pathology, University and Polytechnic Hospital La Fe, Valencia, Spain., Veiga N; Department of Obstetrics and Gynecology, Complejo Hospitalario de Navarra, Pamplona, Spain., Muruzabal JC; Department of Obstetrics and Gynecology, Complejo Hospitalario de Navarra, Pamplona, Spain., Arencibia O; Department of Obstetrics and Gynecology, Complejo Hospitalario Universitario Insular-Materno Infantil, Las Palmas de Gran Canaria, Spain., Andujar M; Department of Pathology, Complejo Hospitalario Universitario Insular-Materno Infantil, Las Palmas de Gran Canaria, Spain., Nieto A; Department of Gynecology and Obstetrics, Gynecology Oncology Unit, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain., Iacoponi S; Department of Obstetrics and Gynecology, Hospital Quironsalud de Madrid, Spain., Marquez F; Department of Obstetrics and Gynecology, Hospital Universitario Virgen Macarena, Sevilla, Spain., Monleón J; Department of Pediatrics, Obstetrics and Gynecology, University of Valencia, Valencia, Spain; Department of Obstetrics and Gynecology, University and Polytechnic Hospital La Fe, Valencia, Spain., Domingo S; Department of Gynecologic Oncology University and Polytechnic Hospital La Fe, Valencia, Spain; Gynecological Tumours, Breast and Hereditary Cancer Research Group, La Fe Health Research Institute (IISLAFE), Valencia, Spain; Department of Pediatrics, Obstetrics and Gynecology, University of Valencia, Valencia, Spain., Volkov P; Carlos Simon Foundation, Valencia, Spain., Simón C; Carlos Simon Foundation, Valencia, Spain; INCLIVA Health Research Institute, Valencia, Spain; Department of Pediatrics, Obstetrics and Gynecology, University of Valencia, Valencia, Spain; Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Electronic address: carlos.simon@uv.es., Mas A; Carlos Simon Foundation, Valencia, Spain; INCLIVA Health Research Institute, Valencia, Spain. Electronic address: amas@fundacioncarlossimon.com.
Corporate Authors: MYOSARC Consortium
Source: American journal of obstetrics and gynecology [Am J Obstet Gynecol] 2026 Jul 23. Date of Electronic Publication: 2026 Jul 23.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0370476 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6868 (Electronic) Linking ISSN: 00029378 NLM ISO Abbreviation: Am J Obstet Gynecol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Liquid Biopsy Cell-free RNA-based Machine Learning Enables Preoperative Risk-Stratification of Uterine Leiomyosarcoma.
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  Data: <searchLink fieldCode="AU" term="%22Stahlschmidt+SR%22">Stahlschmidt SR</searchLink>; Carlos Simon Foundation, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Lago+V%22">Lago V</searchLink>; Department of Gynecologic Oncology University and Polytechnic Hospital La Fe, Valencia, Spain; Gynecological Tumours, Breast and Hereditary Cancer Research Group, La Fe Health Research Institute (IISLAFE), Valencia, Spain; CEU Cardenal Herrera University, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Machado-López+A%22">Machado-López A</searchLink>; Carlos Simon Foundation, Valencia, Spain; INCLIVA Health Research Institute, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Boldú-Fernández+S%22">Boldú-Fernández S</searchLink>; Carlos Simon Foundation, Valencia, Spain; INCLIVA Health Research Institute, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Lara+E%22">Lara E</searchLink>; Carlos Simon Foundation, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Gómez+C%22">Gómez C</searchLink>; R&D Department, Igenomix SL, Paterna, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Valbuena+D%22">Valbuena D</searchLink>; R&D Department, Igenomix SL, Paterna, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Amadoz+A%22">Amadoz A</searchLink>; R&D Department, Igenomix SL, Paterna, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Jiménez-Almazan+J%22">Jiménez-Almazan J</searchLink>; R&D Department, Igenomix SL, Paterna, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Montero+B%22">Montero B</searchLink>; Department of Pathology, University and Polytechnic Hospital La Fe, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Veiga+N%22">Veiga N</searchLink>; Department of Obstetrics and Gynecology, Complejo Hospitalario de Navarra, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Muruzabal+JC%22">Muruzabal JC</searchLink>; Department of Obstetrics and Gynecology, Complejo Hospitalario de Navarra, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Arencibia+O%22">Arencibia O</searchLink>; Department of Obstetrics and Gynecology, Complejo Hospitalario Universitario Insular-Materno Infantil, Las Palmas de Gran Canaria, Spain.<br /><searchLink fieldCode="AU" term="%22Andujar+M%22">Andujar M</searchLink>; Department of Pathology, Complejo Hospitalario Universitario Insular-Materno Infantil, Las Palmas de Gran Canaria, Spain.<br /><searchLink fieldCode="AU" term="%22Nieto+A%22">Nieto A</searchLink>; Department of Gynecology and Obstetrics, Gynecology Oncology Unit, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain.<br /><searchLink fieldCode="AU" term="%22Iacoponi+S%22">Iacoponi S</searchLink>; Department of Obstetrics and Gynecology, Hospital Quironsalud de Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Marquez+F%22">Marquez F</searchLink>; Department of Obstetrics and Gynecology, Hospital Universitario Virgen Macarena, Sevilla, Spain.<br /><searchLink fieldCode="AU" term="%22Monleón+J%22">Monleón J</searchLink>; Department of Pediatrics, Obstetrics and Gynecology, University of Valencia, Valencia, Spain; Department of Obstetrics and Gynecology, University and Polytechnic Hospital La Fe, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Domingo+S%22">Domingo S</searchLink>; Department of Gynecologic Oncology University and Polytechnic Hospital La Fe, Valencia, Spain; Gynecological Tumours, Breast and Hereditary Cancer Research Group, La Fe Health Research Institute (IISLAFE), Valencia, Spain; Department of Pediatrics, Obstetrics and Gynecology, University of Valencia, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Volkov+P%22">Volkov P</searchLink>; Carlos Simon Foundation, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Simón+C%22">Simón C</searchLink>; Carlos Simon Foundation, Valencia, Spain; INCLIVA Health Research Institute, Valencia, Spain; Department of Pediatrics, Obstetrics and Gynecology, University of Valencia, Valencia, Spain; Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Electronic address: carlos.simon@uv.es.<br /><searchLink fieldCode="AU" term="%22Mas+A%22">Mas A</searchLink>; Carlos Simon Foundation, Valencia, Spain; INCLIVA Health Research Institute, Valencia, Spain. Electronic address: amas@fundacioncarlossimon.com.
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