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HELZ is a RNA-DNA helicase that resolves R loops to facilitate homologous recombination repair.

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Title: HELZ is a RNA-DNA helicase that resolves R loops to facilitate homologous recombination repair.
Authors: Haji-Seyed-Javadi R; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA., Koyen AE; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA., Rath SK; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA., Wu B; Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Madden MZ; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA., Hou Y; Department of Human Genetics and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA., Kapoor-Vazirani P; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA., Roshika R; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA., Aiello M; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA., Luong NC; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA., Tseng WC; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA., Sesay F; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA., Kim JS; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA., Tan T; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA., Kim S; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA., Gao B; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA., Song BS; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA., Kenney AM; Department of Pediatrics and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA., Connolly EC; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA., Yang L; Department of Surgery and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA., Xhemalce B; Department of Biochemistry and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA., Li X; Department of Pathology and Laboratory Medicine and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA., Switchenko JM; Department of Biostatistics and Bioinformatics and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA., Yang X; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA., Buchwald ZS; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA., Deng X; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA., Miller KM; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA., Yao B; Department of Human Genetics and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA., Lan L; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA., Zhao W; Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Yu DS; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA. dsyu@emory.edu.
Source: Nature communications [Nat Commun] 2026 Jul 23; Vol. 17 (1). Date of Electronic Publication: 2026 Jul 23.
Publication Type: Journal Article; Research Support, N.I.H., Intramural
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: HELZ is a RNA-DNA helicase that resolves R loops to facilitate homologous recombination repair.
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  Data: <searchLink fieldCode="AU" term="%22Haji-Seyed-Javadi+R%22">Haji-Seyed-Javadi R</searchLink>; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Koyen+AE%22">Koyen AE</searchLink>; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Rath+SK%22">Rath SK</searchLink>; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Wu+B%22">Wu B</searchLink>; Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Madden+MZ%22">Madden MZ</searchLink>; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Hou+Y%22">Hou Y</searchLink>; Department of Human Genetics and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Kapoor-Vazirani+P%22">Kapoor-Vazirani P</searchLink>; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Roshika+R%22">Roshika R</searchLink>; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Aiello+M%22">Aiello M</searchLink>; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Luong+NC%22">Luong NC</searchLink>; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Tseng+WC%22">Tseng WC</searchLink>; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Sesay+F%22">Sesay F</searchLink>; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Kim+JS%22">Kim JS</searchLink>; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Tan+T%22">Tan T</searchLink>; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Kim+S%22">Kim S</searchLink>; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Gao+B%22">Gao B</searchLink>; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Song+BS%22">Song BS</searchLink>; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Kenney+AM%22">Kenney AM</searchLink>; Department of Pediatrics and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Connolly+EC%22">Connolly EC</searchLink>; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Yang+L%22">Yang L</searchLink>; Department of Surgery and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Xhemalce+B%22">Xhemalce B</searchLink>; Department of Biochemistry and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Department of Pathology and Laboratory Medicine and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Switchenko+JM%22">Switchenko JM</searchLink>; Department of Biostatistics and Bioinformatics and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Yang+X%22">Yang X</searchLink>; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Buchwald+ZS%22">Buchwald ZS</searchLink>; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Deng+X%22">Deng X</searchLink>; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Miller+KM%22">Miller KM</searchLink>; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Yao+B%22">Yao B</searchLink>; Department of Human Genetics and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Lan+L%22">Lan L</searchLink>; Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+W%22">Zhao W</searchLink>; Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Yu+DS%22">Yu DS</searchLink>; Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA. dsyu@emory.edu.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 Jul 23; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 Jul 23.
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