HELZ-BRCA2 complex resolves R-loops to drive transcription-coupled homologous recombination.
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| Title: | HELZ-BRCA2 complex resolves R-loops to drive transcription-coupled homologous recombination. |
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| Authors: | Li W; Department of Biochemistry and Structural Biology, Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Wu B; Department of Biochemistry and Structural Biology, Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Gao B; Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC, USA., Irvin EM; Department of Physics, Center for Human Health and the Environment, Toxicology Program, North Carolina State University, Raleigh, NC, USA., Ghosh A; Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC, USA., Eliaz L; Department of Chemistry & Biochemistry Materials Science, Engineering, and Commercialization Program, Integrated Molecular and Biophysical Chemistry Program, Texas State University, San Marcos, TX, USA., Huang Y; Department of Biochemistry and Structural Biology, Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Kwon Y; Department of Biochemistry and Structural Biology, Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Stiefel CM; Department of Radiation Oncology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Nguyen TTN; Department of Radiation Oncology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Zhao D; Department of Biochemistry and Structural Biology, Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Suarez HJ; Department of Biochemistry and Structural Biology, Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Ni T; Department of Biochemistry and Structural Biology, Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Alejo S; Department of Obstetrics & Gynecology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Fitzgerald O; Department of Biochemistry and Structural Biology, Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Song X; Department of Population Health Sciences, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Rath SK; Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, USA., Wasmuth EV; Department of Biochemistry and Structural Biology, Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Yu DS; Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, USA., Zheng S; Department of Population Health Sciences, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Leung J; Department of Radiation Oncology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Xue X; Department of Chemistry & Biochemistry Materials Science, Engineering, and Commercialization Program, Integrated Molecular and Biophysical Chemistry Program, Texas State University, San Marcos, TX, USA., Wang H; Department of Physics, Center for Human Health and the Environment, Toxicology Program, North Carolina State University, Raleigh, NC, USA., Ji JH; Department of Biochemistry and Structural Biology, Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. jij@uthscsa.edu., Lan L; Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC, USA. li.lan@duke.edu., Zhao W; Department of Biochemistry and Structural Biology, Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. zhaow2@uthscsa.edu. |
| Source: | Nature communications [Nat Commun] 2026 Jul 23; Vol. 17 (1). Date of Electronic Publication: 2026 Jul 23. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-026-75088-4 |
