View in EDS HTML Full Text PDF Full Text

HELZ-BRCA2 complex resolves R-loops to drive transcription-coupled homologous recombination.

Saved in:
Bibliographic Details
Title: HELZ-BRCA2 complex resolves R-loops to drive transcription-coupled homologous recombination.
Authors: Li W; Department of Biochemistry and Structural Biology, Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Wu B; Department of Biochemistry and Structural Biology, Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Gao B; Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC, USA., Irvin EM; Department of Physics, Center for Human Health and the Environment, Toxicology Program, North Carolina State University, Raleigh, NC, USA., Ghosh A; Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC, USA., Eliaz L; Department of Chemistry & Biochemistry Materials Science, Engineering, and Commercialization Program, Integrated Molecular and Biophysical Chemistry Program, Texas State University, San Marcos, TX, USA., Huang Y; Department of Biochemistry and Structural Biology, Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Kwon Y; Department of Biochemistry and Structural Biology, Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Stiefel CM; Department of Radiation Oncology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Nguyen TTN; Department of Radiation Oncology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Zhao D; Department of Biochemistry and Structural Biology, Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Suarez HJ; Department of Biochemistry and Structural Biology, Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Ni T; Department of Biochemistry and Structural Biology, Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Alejo S; Department of Obstetrics & Gynecology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Fitzgerald O; Department of Biochemistry and Structural Biology, Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Song X; Department of Population Health Sciences, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Rath SK; Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, USA., Wasmuth EV; Department of Biochemistry and Structural Biology, Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Yu DS; Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, USA., Zheng S; Department of Population Health Sciences, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Leung J; Department of Radiation Oncology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA., Xue X; Department of Chemistry & Biochemistry Materials Science, Engineering, and Commercialization Program, Integrated Molecular and Biophysical Chemistry Program, Texas State University, San Marcos, TX, USA., Wang H; Department of Physics, Center for Human Health and the Environment, Toxicology Program, North Carolina State University, Raleigh, NC, USA., Ji JH; Department of Biochemistry and Structural Biology, Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. jij@uthscsa.edu., Lan L; Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC, USA. li.lan@duke.edu., Zhao W; Department of Biochemistry and Structural Biology, Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. zhaow2@uthscsa.edu.
Source: Nature communications [Nat Commun] 2026 Jul 23; Vol. 17 (1). Date of Electronic Publication: 2026 Jul 23.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 42493506
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: HELZ-BRCA2 complex resolves R-loops to drive transcription-coupled homologous recombination.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Li+W%22">Li W</searchLink>; Department of Biochemistry and Structural Biology, Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Wu+B%22">Wu B</searchLink>; Department of Biochemistry and Structural Biology, Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Gao+B%22">Gao B</searchLink>; Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Irvin+EM%22">Irvin EM</searchLink>; Department of Physics, Center for Human Health and the Environment, Toxicology Program, North Carolina State University, Raleigh, NC, USA.<br /><searchLink fieldCode="AU" term="%22Ghosh+A%22">Ghosh A</searchLink>; Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Eliaz+L%22">Eliaz L</searchLink>; Department of Chemistry & Biochemistry Materials Science, Engineering, and Commercialization Program, Integrated Molecular and Biophysical Chemistry Program, Texas State University, San Marcos, TX, USA.<br /><searchLink fieldCode="AU" term="%22Huang+Y%22">Huang Y</searchLink>; Department of Biochemistry and Structural Biology, Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Kwon+Y%22">Kwon Y</searchLink>; Department of Biochemistry and Structural Biology, Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Stiefel+CM%22">Stiefel CM</searchLink>; Department of Radiation Oncology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+TTN%22">Nguyen TTN</searchLink>; Department of Radiation Oncology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+D%22">Zhao D</searchLink>; Department of Biochemistry and Structural Biology, Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Suarez+HJ%22">Suarez HJ</searchLink>; Department of Biochemistry and Structural Biology, Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Ni+T%22">Ni T</searchLink>; Department of Biochemistry and Structural Biology, Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Alejo+S%22">Alejo S</searchLink>; Department of Obstetrics & Gynecology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Fitzgerald+O%22">Fitzgerald O</searchLink>; Department of Biochemistry and Structural Biology, Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Song+X%22">Song X</searchLink>; Department of Population Health Sciences, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Rath+SK%22">Rath SK</searchLink>; Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Wasmuth+EV%22">Wasmuth EV</searchLink>; Department of Biochemistry and Structural Biology, Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Yu+DS%22">Yu DS</searchLink>; Department of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Zheng+S%22">Zheng S</searchLink>; Department of Population Health Sciences, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Leung+J%22">Leung J</searchLink>; Department of Radiation Oncology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Xue+X%22">Xue X</searchLink>; Department of Chemistry & Biochemistry Materials Science, Engineering, and Commercialization Program, Integrated Molecular and Biophysical Chemistry Program, Texas State University, San Marcos, TX, USA.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Physics, Center for Human Health and the Environment, Toxicology Program, North Carolina State University, Raleigh, NC, USA.<br /><searchLink fieldCode="AU" term="%22Ji+JH%22">Ji JH</searchLink>; Department of Biochemistry and Structural Biology, Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. jij@uthscsa.edu.<br /><searchLink fieldCode="AU" term="%22Lan+L%22">Lan L</searchLink>; Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC, USA. li.lan@duke.edu.<br /><searchLink fieldCode="AU" term="%22Zhao+W%22">Zhao W</searchLink>; Department of Biochemistry and Structural Biology, Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. zhaow2@uthscsa.edu.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 Jul 23; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 Jul 23.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101528555 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-1723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220411723%22">20411723 </searchLink><i>NLM ISO Abbreviation: </i>Nat Commun <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42493506
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41467-026-75088-4
    Languages:
      – Code: eng
        Text: English
    Titles:
      – TitleFull: HELZ-BRCA2 complex resolves R-loops to drive transcription-coupled homologous recombination.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Li W
      – PersonEntity:
          Name:
            NameFull: Wu B
      – PersonEntity:
          Name:
            NameFull: Gao B
      – PersonEntity:
          Name:
            NameFull: Irvin EM
      – PersonEntity:
          Name:
            NameFull: Ghosh A
      – PersonEntity:
          Name:
            NameFull: Eliaz L
      – PersonEntity:
          Name:
            NameFull: Huang Y
      – PersonEntity:
          Name:
            NameFull: Kwon Y
      – PersonEntity:
          Name:
            NameFull: Stiefel CM
      – PersonEntity:
          Name:
            NameFull: Nguyen TTN
      – PersonEntity:
          Name:
            NameFull: Zhao D
      – PersonEntity:
          Name:
            NameFull: Suarez HJ
      – PersonEntity:
          Name:
            NameFull: Ni T
      – PersonEntity:
          Name:
            NameFull: Alejo S
      – PersonEntity:
          Name:
            NameFull: Fitzgerald O
      – PersonEntity:
          Name:
            NameFull: Song X
      – PersonEntity:
          Name:
            NameFull: Rath SK
      – PersonEntity:
          Name:
            NameFull: Wasmuth EV
      – PersonEntity:
          Name:
            NameFull: Yu DS
      – PersonEntity:
          Name:
            NameFull: Zheng S
      – PersonEntity:
          Name:
            NameFull: Leung J
      – PersonEntity:
          Name:
            NameFull: Xue X
      – PersonEntity:
          Name:
            NameFull: Wang H
      – PersonEntity:
          Name:
            NameFull: Ji JH
      – PersonEntity:
          Name:
            NameFull: Lan L
      – PersonEntity:
          Name:
            NameFull: Zhao W
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 23
              M: 07
              Text: 2026 Jul 23
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 2041-1723
          Numbering:
            – Type: volume
              Value: 17
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Nature communications
              Type: main
ResultId 1