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Single-cell multimodal profiling of pan-cancer cell lines uncovers gene regulatory principles underlying intrinsic cell states and environmental features.

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Title: Single-cell multimodal profiling of pan-cancer cell lines uncovers gene regulatory principles underlying intrinsic cell states and environmental features.
Authors: Xu Z; Laboratory of Single Cell Genomics and Population Dynamics, The Rockefeller University, New York, NY, USA.; The David Rockefeller Graduate Program in Bioscience, The Rockefeller University, New York, NY, USA., Ugurbil A; Laboratory of Single Cell Genomics and Population Dynamics, The Rockefeller University, New York, NY, USA.; The Tri-Institutional M.D.-Ph. D. Program, New York, NY, USA., Kwan J; Laboratory of Single Cell Genomics and Population Dynamics, The Rockefeller University, New York, NY, USA., Schaefer C; Laboratory of Single Cell Genomics and Population Dynamics, The Rockefeller University, New York, NY, USA.; The David Rockefeller Graduate Program in Bioscience, The Rockefeller University, New York, NY, USA., Abdulraouf A; Laboratory of Single Cell Genomics and Population Dynamics, The Rockefeller University, New York, NY, USA.; The Tri-Institutional M.D.-Ph. D. Program, New York, NY, USA., Lu Z; Laboratory of Single Cell Genomics and Population Dynamics, The Rockefeller University, New York, NY, USA.; The David Rockefeller Graduate Program in Bioscience, The Rockefeller University, New York, NY, USA., Tang E; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA., Zhou W; Laboratory of Single Cell Genomics and Population Dynamics, The Rockefeller University, New York, NY, USA. wzhou@rockefeller.edu., Cao J; Laboratory of Single Cell Genomics and Population Dynamics, The Rockefeller University, New York, NY, USA. jcao@rockefeller.edu.
Source: Nature communications [Nat Commun] 2026 Jul 23; Vol. 17 (1). Date of Electronic Publication: 2026 Jul 23.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Single-cell multimodal profiling of pan-cancer cell lines uncovers gene regulatory principles underlying intrinsic cell states and environmental features.
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  Data: <searchLink fieldCode="AU" term="%22Xu+Z%22">Xu Z</searchLink>; Laboratory of Single Cell Genomics and Population Dynamics, The Rockefeller University, New York, NY, USA.; The David Rockefeller Graduate Program in Bioscience, The Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ugurbil+A%22">Ugurbil A</searchLink>; Laboratory of Single Cell Genomics and Population Dynamics, The Rockefeller University, New York, NY, USA.; The Tri-Institutional M.D.-Ph. D. Program, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Kwan+J%22">Kwan J</searchLink>; Laboratory of Single Cell Genomics and Population Dynamics, The Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Schaefer+C%22">Schaefer C</searchLink>; Laboratory of Single Cell Genomics and Population Dynamics, The Rockefeller University, New York, NY, USA.; The David Rockefeller Graduate Program in Bioscience, The Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Abdulraouf+A%22">Abdulraouf A</searchLink>; Laboratory of Single Cell Genomics and Population Dynamics, The Rockefeller University, New York, NY, USA.; The Tri-Institutional M.D.-Ph. D. Program, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lu+Z%22">Lu Z</searchLink>; Laboratory of Single Cell Genomics and Population Dynamics, The Rockefeller University, New York, NY, USA.; The David Rockefeller Graduate Program in Bioscience, The Rockefeller University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Tang+E%22">Tang E</searchLink>; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+W%22">Zhou W</searchLink>; Laboratory of Single Cell Genomics and Population Dynamics, The Rockefeller University, New York, NY, USA. wzhou@rockefeller.edu.<br /><searchLink fieldCode="AU" term="%22Cao+J%22">Cao J</searchLink>; Laboratory of Single Cell Genomics and Population Dynamics, The Rockefeller University, New York, NY, USA. jcao@rockefeller.edu.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2026 Jul 23; Vol. 17 (1). <i>Date of Electronic Publication: </i>2026 Jul 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101528555 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-1723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220411723%22">20411723 </searchLink><i>NLM ISO Abbreviation: </i>Nat Commun <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41467-026-75360-7
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              Text: 2026 Jul 23
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