Single-cell multimodal profiling of pan-cancer cell lines uncovers gene regulatory principles underlying intrinsic cell states and environmental features.

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Title: Single-cell multimodal profiling of pan-cancer cell lines uncovers gene regulatory principles underlying intrinsic cell states and environmental features.
Authors: Xu Z; Laboratory of Single Cell Genomics and Population Dynamics, The Rockefeller University, New York, NY, USA.; The David Rockefeller Graduate Program in Bioscience, The Rockefeller University, New York, NY, USA., Ugurbil A; Laboratory of Single Cell Genomics and Population Dynamics, The Rockefeller University, New York, NY, USA.; The Tri-Institutional M.D.-Ph. D. Program, New York, NY, USA., Kwan J; Laboratory of Single Cell Genomics and Population Dynamics, The Rockefeller University, New York, NY, USA., Schaefer C; Laboratory of Single Cell Genomics and Population Dynamics, The Rockefeller University, New York, NY, USA.; The David Rockefeller Graduate Program in Bioscience, The Rockefeller University, New York, NY, USA., Abdulraouf A; Laboratory of Single Cell Genomics and Population Dynamics, The Rockefeller University, New York, NY, USA.; The Tri-Institutional M.D.-Ph. D. Program, New York, NY, USA., Lu Z; Laboratory of Single Cell Genomics and Population Dynamics, The Rockefeller University, New York, NY, USA.; The David Rockefeller Graduate Program in Bioscience, The Rockefeller University, New York, NY, USA., Tang E; Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA., Zhou W; Laboratory of Single Cell Genomics and Population Dynamics, The Rockefeller University, New York, NY, USA. wzhou@rockefeller.edu., Cao J; Laboratory of Single Cell Genomics and Population Dynamics, The Rockefeller University, New York, NY, USA. jcao@rockefeller.edu.
Source: Nature communications [Nat Commun] 2026 Jul 23; Vol. 17 (1). Date of Electronic Publication: 2026 Jul 23.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-026-75360-7