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Acute rapamycin treatment reveals distinct mechanisms of dysfunction in a maternal inflammation mouse model.

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Title: Acute rapamycin treatment reveals distinct mechanisms of dysfunction in a maternal inflammation mouse model.
Authors: Le Belle JE; Semel Institute for Neuroscience & Human Behavior, Department of Psychiatry, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.; The UCLA Brain Injury Research Center, Department of Neurosurgery, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.; UCLA Intellectual and Developmental Disabilities Research Center, Semel Institute, Department of Psychiatry, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA., Condro MC; Semel Institute for Neuroscience & Human Behavior, Department of Psychiatry, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA., Cepeda C; Semel Institute for Neuroscience & Human Behavior, Department of Psychiatry, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA., Oikonomou KD; Semel Institute for Neuroscience & Human Behavior, Department of Psychiatry, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA., Tessema K; Semel Institute for Neuroscience & Human Behavior, Department of Psychiatry, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA., Dudley L; Semel Institute for Neuroscience & Human Behavior, Department of Psychiatry, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA., Schoenfield J; The UCLA Brain Injury Research Center, Department of Neurosurgery, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA., Kawaguchi R; Semel Institute for Neuroscience & Human Behavior, Department of Psychiatry, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA., Geschwind D; Semel Institute for Neuroscience & Human Behavior, Department of Psychiatry, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.; Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.; Department of Human Genetics, UCLA, Los Angeles, CA, USA.; Brain Research Institute, UCLA, Los Angeles, CA, USA., Silva AJ; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.; Brain Research Institute, UCLA, Los Angeles, CA, USA.; Department of Neurobiology, UCLA, Los Angeles, CA, USA.; Department of Psychology, UCLA, Los Angeles, CA, USA.; Integrative Center for Learning and Memory, UCLA, Los Angeles, CA, USA., Zhang Z; Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of California, San Francisco, CA, USA., Shokat K; Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of California, San Francisco, CA, USA., Harris NG; The UCLA Brain Injury Research Center, Department of Neurosurgery, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA. ngharris@ucla.edu.; UCLA Intellectual and Developmental Disabilities Research Center, Semel Institute, Department of Psychiatry, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA. ngharris@ucla.edu.; Brain Research Institute, UCLA, Los Angeles, CA, USA. ngharris@ucla.edu., Kornblum HI; Semel Institute for Neuroscience & Human Behavior, Department of Psychiatry, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA. hkornblum@mednet.ucla.edu.; UCLA Intellectual and Developmental Disabilities Research Center, Semel Institute, Department of Psychiatry, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA. hkornblum@mednet.ucla.edu.; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA. hkornblum@mednet.ucla.edu.; Brain Research Institute, UCLA, Los Angeles, CA, USA. hkornblum@mednet.ucla.edu.; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. hkornblum@mednet.ucla.edu.; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. hkornblum@mednet.ucla.edu.
Source: Nature communications [Nat Commun] 2026 Jul 23; Vol. 17 (1). Date of Electronic Publication: 2026 Jul 23.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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