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Mitochondrial metabolism determines chemotherapy sensitivity in colorectal cancer.

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Title: Mitochondrial metabolism determines chemotherapy sensitivity in colorectal cancer.
Authors: Moss DY; Johnston Cancer Research Centre, Queen's University Belfast, Belfast, Northern Ireland, UK., Brown CN; Johnston Cancer Research Centre, Queen's University Belfast, Belfast, Northern Ireland, UK., Shaw AM; Johnston Cancer Research Centre, Queen's University Belfast, Belfast, Northern Ireland, UK., McCann C; Johnston Cancer Research Centre, Queen's University Belfast, Belfast, Northern Ireland, UK., Lewis N; Johnston Cancer Research Centre, Queen's University Belfast, Belfast, Northern Ireland, UK., Downs M; Johnston Cancer Research Centre, Queen's University Belfast, Belfast, Northern Ireland, UK., Wurelly R; Johnston Cancer Research Centre, Queen's University Belfast, Belfast, Northern Ireland, UK., Cunningham C; Johnston Cancer Research Centre, Queen's University Belfast, Belfast, Northern Ireland, UK., Philips A; Johnston Cancer Research Centre, Queen's University Belfast, Belfast, Northern Ireland, UK., Doherty N; Johnston Cancer Research Centre, Queen's University Belfast, Belfast, Northern Ireland, UK., Gallagher S; Johnston Cancer Research Centre, Queen's University Belfast, Belfast, Northern Ireland, UK., McDaid WJ; Johnston Cancer Research Centre, Queen's University Belfast, Belfast, Northern Ireland, UK., Roe A; Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland., Coughlan AY; Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland., Cavanagh B; Cellular and Molecular Imaging Core, Royal College of Surgeons in Ireland, Dublin, Ireland., Ormsby C; Johnston Cancer Research Centre, Queen's University Belfast, Belfast, Northern Ireland, UK., Falcone F; Johnston Cancer Research Centre, Queen's University Belfast, Belfast, Northern Ireland, UK., McCole R; Johnston Cancer Research Centre, Queen's University Belfast, Belfast, Northern Ireland, UK., Monteith S; Johnston Cancer Research Centre, Queen's University Belfast, Belfast, Northern Ireland, UK., Rogan E; Johnston Cancer Research Centre, Queen's University Belfast, Belfast, Northern Ireland, UK., Malla SB; Johnston Cancer Research Centre, Queen's University Belfast, Belfast, Northern Ireland, UK., Emerson AJ; Johnston Cancer Research Centre, Queen's University Belfast, Belfast, Northern Ireland, UK., Mohammed-Smith L; Johnston Cancer Research Centre, Queen's University Belfast, Belfast, Northern Ireland, UK., Sharkey S; Johnston Cancer Research Centre, Queen's University Belfast, Belfast, Northern Ireland, UK., Leonard A; Johnston Cancer Research Centre, Queen's University Belfast, Belfast, Northern Ireland, UK., Gallagher PF; Johnston Cancer Research Centre, Queen's University Belfast, Belfast, Northern Ireland, UK., Banerjee A; Johnston Cancer Research Centre, Queen's University Belfast, Belfast, Northern Ireland, UK., Van Schaeybroeck S; Johnston Cancer Research Centre, Queen's University Belfast, Belfast, Northern Ireland, UK., Pandor S; Agilent Technologies, Cheadle, UK., Quinn B; Institute for Global Food Security, Queen's University Belfast, Belfast, Northern Ireland, UK., Greer B; Institute for Global Food Security, Queen's University Belfast, Belfast, Northern Ireland, UK.; Agri-Food and Biosciences Institute, Chemical Surveillance Branch, Veterinary Sciences Division, Belfast, Northern Ireland, UK., Elliott C; Institute for Global Food Security, Queen's University Belfast, Belfast, Northern Ireland, UK.; International Joint Research Centre on Food Security (IJC-FOODSEC), Khong Luang, Thailand.; School of Food Science and Technology, Faculty of Science and Technology, Thammasat University, Khong Luang, Thailand., Maguire S; Johnston Cancer Research Centre, Queen's University Belfast, Belfast, Northern Ireland, UK., Ryan AE; Discipline of Pharmacology and Therapeutics, School of Medicine, College of Medicine, Nursing and Health Sciences, University of Galway, Galway, Ireland., Dunne PD; Johnston Cancer Research Centre, Queen's University Belfast, Belfast, Northern Ireland, UK.; CRUK Scotland Institute, Glasgow, UK., Mallon M; Johnston Cancer Research Centre, Queen's University Belfast, Belfast, Northern Ireland, UK., Craig S; Johnston Cancer Research Centre, Queen's University Belfast, Belfast, Northern Ireland, UK., Aftab O; Biosciences Institute, Newcastle University, Newcastle Upon Tyne, UK., Greaves LC; Biosciences Institute, Newcastle University, Newcastle Upon Tyne, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Marzullo BP; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK., Tennant DA; Department of Metabolism and Systems Science, College of Medicine and Health, University of Birmingham, Birmingham, UK., Coyle V; Johnston Cancer Research Centre, Queen's University Belfast, Belfast, Northern Ireland, UK., Mills IG; Johnston Cancer Research Centre, Queen's University Belfast, Belfast, Northern Ireland, UK., Sansom O; CRUK Scotland Institute, Glasgow, UK.; School of Cancer Sciences, University of Glasgow, Glasgow, UK., Ní Chonghaile T; Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland., Longley DB; Johnston Cancer Research Centre, Queen's University Belfast, Belfast, Northern Ireland, UK., McDade SS; Johnston Cancer Research Centre, Queen's University Belfast, Belfast, Northern Ireland, UK., LaBonte MJ; Johnston Cancer Research Centre, Queen's University Belfast, Belfast, Northern Ireland, UK., Kerr EM; Johnston Cancer Research Centre, Queen's University Belfast, Belfast, Northern Ireland, UK. emma.kerr@qub.ac.uk.
Source: Nature metabolism [Nat Metab] 2026 Jul 23. Date of Electronic Publication: 2026 Jul 23.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE
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