Using enantioselective biosensors to evolve asymmetric biocatalysts.

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Title: Using enantioselective biosensors to evolve asymmetric biocatalysts.
Authors: d'Oelsnitz S; Synthetic Biology HIVE, Department of Systems Biology, Harvard Medical School, Boston, MA, USA. simonsnitz@gmail.com.; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA. simonsnitz@gmail.com.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA. simonsnitz@gmail.com., Kim W; McKetta Department of Chemical Engineering, University of Texas at Austin, Austin, TX, USA., Zhao NN; Department of Systems Biology, Harvard Medical School, Boston, MA, USA., Hardtke H; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA., Ikonomova SP; National Institute of Standards and Technology, Gaithersburg, MD, USA., Alperovich N; National Institute of Standards and Technology, Gaithersburg, MD, USA., Vasilyeva O; National Institute of Standards and Technology, Gaithersburg, MD, USA., James MJ; Department of Microbiology, Harvard Medical School, Boston, MA, USA., Zigon ES; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA., Cory MB; Synthetic Biology HIVE, Department of Systems Biology, Harvard Medical School, Boston, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA., Johnson CD; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA., Ellington AD; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.; Center for Systems and Synthetic Biology, University of Texas at Austin, Austin, TX, USA., Justman QA; Synthetic Biology HIVE, Department of Systems Biology, Harvard Medical School, Boston, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA., Springer M; Synthetic Biology HIVE, Department of Systems Biology, Harvard Medical School, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA., Zhang YJ; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA., Silver PA; Synthetic Biology HIVE, Department of Systems Biology, Harvard Medical School, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA., Ross D; National Institute of Standards and Technology, Gaithersburg, MD, USA.
Source: Nature chemical biology [Nat Chem Biol] 2026 Jul 23. Date of Electronic Publication: 2026 Jul 23.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22d'Oelsnitz+S%22">d'Oelsnitz S</searchLink>; Synthetic Biology HIVE, Department of Systems Biology, Harvard Medical School, Boston, MA, USA. simonsnitz@gmail.com.; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA. simonsnitz@gmail.com.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA. simonsnitz@gmail.com.<br /><searchLink fieldCode="AU" term="%22Kim+W%22">Kim W</searchLink>; McKetta Department of Chemical Engineering, University of Texas at Austin, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+NN%22">Zhao NN</searchLink>; Department of Systems Biology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hardtke+H%22">Hardtke H</searchLink>; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Ikonomova+SP%22">Ikonomova SP</searchLink>; National Institute of Standards and Technology, Gaithersburg, MD, USA.<br /><searchLink fieldCode="AU" term="%22Alperovich+N%22">Alperovich N</searchLink>; National Institute of Standards and Technology, Gaithersburg, MD, USA.<br /><searchLink fieldCode="AU" term="%22Vasilyeva+O%22">Vasilyeva O</searchLink>; National Institute of Standards and Technology, Gaithersburg, MD, USA.<br /><searchLink fieldCode="AU" term="%22James+MJ%22">James MJ</searchLink>; Department of Microbiology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Zigon+ES%22">Zigon ES</searchLink>; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cory+MB%22">Cory MB</searchLink>; Synthetic Biology HIVE, Department of Systems Biology, Harvard Medical School, Boston, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+CD%22">Johnson CD</searchLink>; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Ellington+AD%22">Ellington AD</searchLink>; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.; Center for Systems and Synthetic Biology, University of Texas at Austin, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Justman+QA%22">Justman QA</searchLink>; Synthetic Biology HIVE, Department of Systems Biology, Harvard Medical School, Boston, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Springer+M%22">Springer M</searchLink>; Synthetic Biology HIVE, Department of Systems Biology, Harvard Medical School, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+YJ%22">Zhang YJ</searchLink>; Department of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.<br /><searchLink fieldCode="AU" term="%22Silver+PA%22">Silver PA</searchLink>; Synthetic Biology HIVE, Department of Systems Biology, Harvard Medical School, Boston, MA, USA.; Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ross+D%22">Ross D</searchLink>; National Institute of Standards and Technology, Gaithersburg, MD, USA.
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