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Simvastatin enhances the antitumor activity of temsirolimus through AMPK-associated metabolic modulation in clear-cell renal cell carcinoma.

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Title: Simvastatin enhances the antitumor activity of temsirolimus through AMPK-associated metabolic modulation in clear-cell renal cell carcinoma.
Authors: Chen HY; School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan., Cheng CJ; Department of Pathology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Department of Pathology, Taipei Medical University Hospital, Taipei, Taiwan., Hsu TH; Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 11031, Taiwan., Tung SY; Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 11031, Taiwan., Chou FN; Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 11031, Taiwan., Satapathy MK; Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 11031, Taiwan., Juan SH; Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 11031, Taiwan. juansh@tmu.edu.tw.
Source: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2026 Jul 24. Date of Electronic Publication: 2026 Jul 24.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Simvastatin enhances the antitumor activity of temsirolimus through AMPK-associated metabolic modulation in clear-cell renal cell carcinoma.
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  Data: <searchLink fieldCode="AU" term="%22Chen+HY%22">Chen HY</searchLink>; School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Cheng+CJ%22">Cheng CJ</searchLink>; Department of Pathology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Department of Pathology, Taipei Medical University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsu+TH%22">Hsu TH</searchLink>; Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 11031, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tung+SY%22">Tung SY</searchLink>; Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 11031, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chou+FN%22">Chou FN</searchLink>; Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 11031, Taiwan.<br /><searchLink fieldCode="AU" term="%22Satapathy+MK%22">Satapathy MK</searchLink>; Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 11031, Taiwan.<br /><searchLink fieldCode="AU" term="%22Juan+SH%22">Juan SH</searchLink>; Department of Physiology, School of Medicine, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 11031, Taiwan. juansh@tmu.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%220326264%22">Naunyn-Schmiedeberg's archives of pharmacology</searchLink> [Naunyn Schmiedebergs Arch Pharmacol] 2026 Jul 24. <i>Date of Electronic Publication: </i>2026 Jul 24.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Verlag%22">Springer Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>0326264 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-1912 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200281298%22">00281298 </searchLink><i>NLM ISO Abbreviation: </i>Naunyn Schmiedebergs Arch Pharmacol <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s00210-026-05733-8
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        Text: English
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      – TitleFull: Simvastatin enhances the antitumor activity of temsirolimus through AMPK-associated metabolic modulation in clear-cell renal cell carcinoma.
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            – D: 24
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              Text: 2026 Jul 24
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              Y: 2026
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