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Targeting chordoma via an isocitrate dehydrogenase-1-dependent susceptibility to redox metabolism.

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Title: Targeting chordoma via an isocitrate dehydrogenase-1-dependent susceptibility to redox metabolism.
Authors: Pun M; Department of Pathology, Laboratory of Brain Tumor Metabolism and Epigenetics, University of Michigan, Ann Arbor, MI, USA., Deogharkar A; Department of Pathology, Laboratory of Brain Tumor Metabolism and Epigenetics, University of Michigan, Ann Arbor, MI, USA., Natarajan SK; Department of Pathology, Laboratory of Brain Tumor Metabolism and Epigenetics, University of Michigan, Ann Arbor, MI, USA., Nuechterlein N; Department of Pathology, Laboratory of Brain Tumor Metabolism and Epigenetics, University of Michigan, Ann Arbor, MI, USA., Tian W; Department of Pathology, Laboratory of Brain Tumor Metabolism and Epigenetics, University of Michigan, Ann Arbor, MI, USA., Ji S; Department of Pediatrics, Michigan Medicine, Ann Arbor, MI, USA., Young E; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA., Yang F; Department of Pathology, Children's Hospital of Los Angeles, Los Angeles, CA, 90027, USA., Hawes D; Department of Pathology, Children's Hospital of Los Angeles, Los Angeles, CA, 90027, USA., Andren AC; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Owen JH; Department of Otolaryngology/Head Neck Surgery, University of Michigan School of Medicine, Ann Arbor, MI, 48109-5616, USA., Rau S; Department of Pathology, Laboratory of Brain Tumor Metabolism and Epigenetics, University of Michigan, Ann Arbor, MI, USA., Su F; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI, USA., Cao X; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI, USA., Parolia A; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.; Department of Urology, University of Michigan, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., Prince M; Department of Otolaryngology/Head Neck Surgery, University of Michigan School of Medicine, Ann Arbor, MI, 48109-5616, USA., Fry J; Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Gardner PA; Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Yang R; Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Judkins AR; Department of Pathology, Children's Hospital of Los Angeles, Los Angeles, CA, 90027, USA., Koschmann CJ; Department of Pediatrics, Michigan Medicine, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., Venteicher AS; Department of Neurosurgery and Center for Skull Base and Pituitary Surgery, University of Minnesota, Minneapolis, MN, USA., Lyssiotis CA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA., Chinnaiyan AM; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA., Venneti S; Department of Pathology, Laboratory of Brain Tumor Metabolism and Epigenetics, University of Michigan, Ann Arbor, MI, USA. svenneti@med.umich.edu.; Department of Pediatrics, Michigan Medicine, Ann Arbor, MI, USA. svenneti@med.umich.edu.; Department of Pathology, University of Michigan, Ann Arbor, MI, USA. svenneti@med.umich.edu.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA. svenneti@med.umich.edu.
Source: Acta neuropathologica [Acta Neuropathol] 2026 Jul 23; Vol. 152 (1). Date of Electronic Publication: 2026 Jul 23.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeting chordoma via an isocitrate dehydrogenase-1-dependent susceptibility to redox metabolism.
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  Data: <searchLink fieldCode="AU" term="%22Pun+M%22">Pun M</searchLink>; Department of Pathology, Laboratory of Brain Tumor Metabolism and Epigenetics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Deogharkar+A%22">Deogharkar A</searchLink>; Department of Pathology, Laboratory of Brain Tumor Metabolism and Epigenetics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Natarajan+SK%22">Natarajan SK</searchLink>; Department of Pathology, Laboratory of Brain Tumor Metabolism and Epigenetics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Nuechterlein+N%22">Nuechterlein N</searchLink>; Department of Pathology, Laboratory of Brain Tumor Metabolism and Epigenetics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Tian+W%22">Tian W</searchLink>; Department of Pathology, Laboratory of Brain Tumor Metabolism and Epigenetics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Ji+S%22">Ji S</searchLink>; Department of Pediatrics, Michigan Medicine, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Young+E%22">Young E</searchLink>; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Yang+F%22">Yang F</searchLink>; Department of Pathology, Children's Hospital of Los Angeles, Los Angeles, CA, 90027, USA.<br /><searchLink fieldCode="AU" term="%22Hawes+D%22">Hawes D</searchLink>; Department of Pathology, Children's Hospital of Los Angeles, Los Angeles, CA, 90027, USA.<br /><searchLink fieldCode="AU" term="%22Andren+AC%22">Andren AC</searchLink>; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Owen+JH%22">Owen JH</searchLink>; Department of Otolaryngology/Head Neck Surgery, University of Michigan School of Medicine, Ann Arbor, MI, 48109-5616, USA.<br /><searchLink fieldCode="AU" term="%22Rau+S%22">Rau S</searchLink>; Department of Pathology, Laboratory of Brain Tumor Metabolism and Epigenetics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Su+F%22">Su F</searchLink>; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Cao+X%22">Cao X</searchLink>; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.; Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Parolia+A%22">Parolia A</searchLink>; Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, MI, USA.; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.; Department of Urology, University of Michigan, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Prince+M%22">Prince M</searchLink>; Department of Otolaryngology/Head Neck Surgery, University of Michigan School of Medicine, Ann Arbor, MI, 48109-5616, USA.<br /><searchLink fieldCode="AU" term="%22Fry+J%22">Fry J</searchLink>; Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.<br /><searchLink fieldCode="AU" term="%22Gardner+PA%22">Gardner PA</searchLink>; Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Yang+R%22">Yang R</searchLink>; Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.<br /><searchLink fieldCode="AU" term="%22Judkins+AR%22">Judkins AR</searchLink>; Department of Pathology, Children's Hospital of Los Angeles, Los Angeles, CA, 90027, USA.<br /><searchLink fieldCode="AU" term="%22Koschmann+CJ%22">Koschmann CJ</searchLink>; Department of Pediatrics, Michigan Medicine, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Venteicher+AS%22">Venteicher AS</searchLink>; Department of Neurosurgery and Center for Skull Base and Pituitary Surgery, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Lyssiotis+CA%22">Lyssiotis CA</searchLink>; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Chinnaiyan+AM%22">Chinnaiyan AM</searchLink>; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.; Department of Pathology, University of Michigan, Ann Arbor, MI, USA.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA.; Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.<br /><searchLink fieldCode="AU" term="%22Venneti+S%22">Venneti S</searchLink>; Department of Pathology, Laboratory of Brain Tumor Metabolism and Epigenetics, University of Michigan, Ann Arbor, MI, USA. svenneti@med.umich.edu.; Department of Pediatrics, Michigan Medicine, Ann Arbor, MI, USA. svenneti@med.umich.edu.; Department of Pathology, University of Michigan, Ann Arbor, MI, USA. svenneti@med.umich.edu.; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA. svenneti@med.umich.edu.
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  Data: <searchLink fieldCode="JN" term="%220412041%22">Acta neuropathologica</searchLink> [Acta Neuropathol] 2026 Jul 23; Vol. 152 (1). <i>Date of Electronic Publication: </i>2026 Jul 23.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Verlag%22">Springer Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>0412041 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-0533 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200016322%22">00016322 </searchLink><i>NLM ISO Abbreviation: </i>Acta Neuropathol <i>Subsets: </i>MEDLINE
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