Intensive Blood-Pressure Control for the Prevention of Major Cardiovascular Events in Patients with Type 2 Diabetes: Rationale, Design and Baseline Characteristics of the OPTIMAL-DIABETES Randomized Trial.
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| Title: | Intensive Blood-Pressure Control for the Prevention of Major Cardiovascular Events in Patients with Type 2 Diabetes: Rationale, Design and Baseline Characteristics of the OPTIMAL-DIABETES Randomized Trial. |
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| Authors: | Santo K; Hospital Israelita Albert Einstein, São Paulo, Brazil. Electronic address: karla.santo@einstein.br., Martins E; Hospital Israelita Albert Einstein, São Paulo, Brazil., Silva GS; Hospital Israelita Albert Einstein, São Paulo, Brazil; Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil., Guimarães PO; Hospital Israelita Albert Einstein, São Paulo, Brazil., Tavares CAM; Hospital Israelita Albert Einstein, São Paulo, Brazil; Instituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil., Brainer J; Hospital Israelita Albert Einstein, São Paulo, Brazil; Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil., Monfardini F; Hospital Israelita Albert Einstein, São Paulo, Brazil., Nieri J; Hospital Israelita Albert Einstein, São Paulo, Brazil., Assis SRL; Hospital Israelita Albert Einstein, São Paulo, Brazil., Felício JS; João de Barros Barreto University Hospital, Federal University of Pará, Belém, Brazil., Silveira FS; Centro de Pesquisa Clínica do Coração, Aracaju, Brazil., Feitosa ADM; Pronto Socorro Cardiológico de Pernambuco (PROCAPE), University of Pernambuco, Recife, Brazil., Hissa MN; Centro de Pesquisas em Diabetes e Doenças Endócrino-Metabólicas /Clínica Popular Endocrinologia, Fortaleza, Brazil., Sobral-Filho DC; Pronto Socorro Cardiológico de Pernambuco (PROCAPE), University of Pernambuco, Recife, Brazil., Vilela-Martin JF; State Medicine School of São José do Rio Preto (FAMERP), São José do Rio Preto, Brazil., Cestario EES; State Medicine School of São José do Rio Preto (FAMERP), São José do Rio Preto, Brazil; University Center of Votuporanga (UNIFEV), Votuporanga, Brazil., Yugar-Toledo JC; State Medicine School of São José do Rio Preto (FAMERP), São José do Rio Preto, Brazil., Batista MC; Hospital Israelita Albert Einstein, São Paulo, Brazil; Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil., Turatti L; Hospital Israelita Albert Einstein, São Paulo, Brazil., Brandão AA; Faculty of Medical Sciences, Rio de Janeiro State University (UERJ), Rio de Janeiro, Brazil., Barroso WS; Hypertension Unit, Medicine School, Federal University of Goiás, Goiânia, Brazil., Sposito AC; Clinical Research Center, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil., Drager LF; Instituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil; Unidade de Hipertensão, Disciplina de Nefrologia, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil., Bortolotto LA; Instituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil., Fuchs SC; Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Franken M; Hospital Israelita Albert Einstein, São Paulo, Brazil., Lemos PA; Hospital Israelita Albert Einstein, São Paulo, Brazil; Faculty of Health Sciences, Universidad Autónoma de Chile, Providencia, Chile., Santos RD; Hospital Israelita Albert Einstein, São Paulo, Brazil; Instituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil., Rodgers A; George Institute for Global Health, Sydney, Australia., Whelton PK; Tulane University Celia Scott Weatherhead School of Public Health and Tropical Medicine, New Orleans, USA., Fuchs FD; Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Berwanger O; George Institute for Global Health UK, London, United Kingdom; Imperial College London, London, United Kingdom. |
| Source: | American heart journal [Am Heart J] 2026 Jul 24, pp. 107545. Date of Electronic Publication: 2026 Jul 24. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Mosby Country of Publication: United States NLM ID: 0370465 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6744 (Electronic) Linking ISSN: 00028703 NLM ISO Abbreviation: Am Heart J Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42498010 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Intensive Blood-Pressure Control for the Prevention of Major Cardiovascular Events in Patients with Type 2 Diabetes: Rationale, Design and Baseline Characteristics of the OPTIMAL-DIABETES Randomized Trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Santo+K%22">Santo K</searchLink>; Hospital Israelita Albert Einstein, São Paulo, Brazil. Electronic address: karla.santo@einstein.br.<br /><searchLink fieldCode="AU" term="%22Martins+E%22">Martins E</searchLink>; Hospital Israelita Albert Einstein, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Silva+GS%22">Silva GS</searchLink>; Hospital Israelita Albert Einstein, São Paulo, Brazil; Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Guimarães+PO%22">Guimarães PO</searchLink>; Hospital Israelita Albert Einstein, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Tavares+CAM%22">Tavares CAM</searchLink>; Hospital Israelita Albert Einstein, São Paulo, Brazil; Instituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Brainer+J%22">Brainer J</searchLink>; Hospital Israelita Albert Einstein, São Paulo, Brazil; Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Monfardini+F%22">Monfardini F</searchLink>; Hospital Israelita Albert Einstein, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Nieri+J%22">Nieri J</searchLink>; Hospital Israelita Albert Einstein, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Assis+SRL%22">Assis SRL</searchLink>; Hospital Israelita Albert Einstein, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Felício+JS%22">Felício JS</searchLink>; João de Barros Barreto University Hospital, Federal University of Pará, Belém, Brazil.<br /><searchLink fieldCode="AU" term="%22Silveira+FS%22">Silveira FS</searchLink>; Centro de Pesquisa Clínica do Coração, Aracaju, Brazil.<br /><searchLink fieldCode="AU" term="%22Feitosa+ADM%22">Feitosa ADM</searchLink>; Pronto Socorro Cardiológico de Pernambuco (PROCAPE), University of Pernambuco, Recife, Brazil.<br /><searchLink fieldCode="AU" term="%22Hissa+MN%22">Hissa MN</searchLink>; Centro de Pesquisas em Diabetes e Doenças Endócrino-Metabólicas /Clínica Popular Endocrinologia, Fortaleza, Brazil.<br /><searchLink fieldCode="AU" term="%22Sobral-Filho+DC%22">Sobral-Filho DC</searchLink>; Pronto Socorro Cardiológico de Pernambuco (PROCAPE), University of Pernambuco, Recife, Brazil.<br /><searchLink fieldCode="AU" term="%22Vilela-Martin+JF%22">Vilela-Martin JF</searchLink>; State Medicine School of São José do Rio Preto (FAMERP), São José do Rio Preto, Brazil.<br /><searchLink fieldCode="AU" term="%22Cestario+EES%22">Cestario EES</searchLink>; State Medicine School of São José do Rio Preto (FAMERP), São José do Rio Preto, Brazil; University Center of Votuporanga (UNIFEV), Votuporanga, Brazil.<br /><searchLink fieldCode="AU" term="%22Yugar-Toledo+JC%22">Yugar-Toledo JC</searchLink>; State Medicine School of São José do Rio Preto (FAMERP), São José do Rio Preto, Brazil.<br /><searchLink fieldCode="AU" term="%22Batista+MC%22">Batista MC</searchLink>; Hospital Israelita Albert Einstein, São Paulo, Brazil; Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Turatti+L%22">Turatti L</searchLink>; Hospital Israelita Albert Einstein, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Brandão+AA%22">Brandão AA</searchLink>; Faculty of Medical Sciences, Rio de Janeiro State University (UERJ), Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Barroso+WS%22">Barroso WS</searchLink>; Hypertension Unit, Medicine School, Federal University of Goiás, Goiânia, Brazil.<br /><searchLink fieldCode="AU" term="%22Sposito+AC%22">Sposito AC</searchLink>; Clinical Research Center, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil.<br /><searchLink fieldCode="AU" term="%22Drager+LF%22">Drager LF</searchLink>; Instituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil; Unidade de Hipertensão, Disciplina de Nefrologia, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Bortolotto+LA%22">Bortolotto LA</searchLink>; Instituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Fuchs+SC%22">Fuchs SC</searchLink>; Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.<br /><searchLink fieldCode="AU" term="%22Franken+M%22">Franken M</searchLink>; Hospital Israelita Albert Einstein, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Lemos+PA%22">Lemos PA</searchLink>; Hospital Israelita Albert Einstein, São Paulo, Brazil; Faculty of Health Sciences, Universidad Autónoma de Chile, Providencia, Chile.<br /><searchLink fieldCode="AU" term="%22Santos+RD%22">Santos RD</searchLink>; Hospital Israelita Albert Einstein, São Paulo, Brazil; Instituto do Coração (InCor), Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Rodgers+A%22">Rodgers A</searchLink>; George Institute for Global Health, Sydney, Australia.<br /><searchLink fieldCode="AU" term="%22Whelton+PK%22">Whelton PK</searchLink>; Tulane University Celia Scott Weatherhead School of Public Health and Tropical Medicine, New Orleans, USA.<br /><searchLink fieldCode="AU" term="%22Fuchs+FD%22">Fuchs FD</searchLink>; Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.<br /><searchLink fieldCode="AU" term="%22Berwanger+O%22">Berwanger O</searchLink>; George Institute for Global Health UK, London, United Kingdom; Imperial College London, London, United Kingdom. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220370465%22">American heart journal</searchLink> [Am Heart J] 2026 Jul 24, pp. 107545. <i>Date of Electronic Publication: </i>2026 Jul 24. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Mosby%22">Mosby </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0370465 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1097-6744 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200028703%22">00028703 </searchLink><i>NLM ISO Abbreviation: </i>Am Heart J <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42498010 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.ahj.2026.107545 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 107545 Titles: – TitleFull: Intensive Blood-Pressure Control for the Prevention of Major Cardiovascular Events in Patients with Type 2 Diabetes: Rationale, Design and Baseline Characteristics of the OPTIMAL-DIABETES Randomized Trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Santo K – PersonEntity: Name: NameFull: Martins E – PersonEntity: Name: NameFull: Silva GS – PersonEntity: Name: NameFull: Guimarães PO – PersonEntity: Name: NameFull: Tavares CAM – PersonEntity: Name: NameFull: Brainer J – PersonEntity: Name: NameFull: Monfardini F – PersonEntity: Name: NameFull: Nieri J – PersonEntity: Name: NameFull: Assis SRL – PersonEntity: Name: NameFull: Felício JS – PersonEntity: Name: NameFull: Silveira FS – PersonEntity: Name: NameFull: Feitosa ADM – PersonEntity: Name: NameFull: Hissa MN – PersonEntity: Name: NameFull: Sobral-Filho DC – PersonEntity: Name: NameFull: Vilela-Martin JF – PersonEntity: Name: NameFull: Cestario EES – PersonEntity: Name: NameFull: Yugar-Toledo JC – PersonEntity: Name: NameFull: Batista MC – PersonEntity: Name: NameFull: Turatti L – PersonEntity: Name: NameFull: Brandão AA – PersonEntity: Name: NameFull: Barroso WS – PersonEntity: Name: NameFull: Sposito AC – PersonEntity: Name: NameFull: Drager LF – PersonEntity: Name: NameFull: Bortolotto LA – PersonEntity: Name: NameFull: Fuchs SC – PersonEntity: Name: NameFull: Franken M – PersonEntity: Name: NameFull: Lemos PA – PersonEntity: Name: NameFull: Santos RD – PersonEntity: Name: NameFull: Rodgers A – PersonEntity: Name: NameFull: Whelton PK – PersonEntity: Name: NameFull: Fuchs FD – PersonEntity: Name: NameFull: Berwanger O IsPartOfRelationships: – BibEntity: Dates: – D: 24 M: 07 Text: 2026 Jul 24 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1097-6744 Titles: – TitleFull: American heart journal Type: main |
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