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MRD dynamics predicts progression and reveals a vulnerable state for immunotherapy interception in multiple myeloma.

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Title: MRD dynamics predicts progression and reveals a vulnerable state for immunotherapy interception in multiple myeloma.
Authors: Gonzalez C; Cancer Center Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, CIBER-ONC number CB16/12/00369 and CB16/12/00489, Pamplona, Pamplona, Spain., Guerrero C; CIMA, Pamplona, Spain., Larrayoz M; CIMA, Pamplona, Spain., Zabaleta A; Cancer Center Clinica Universidad de Navarra (CCUN), Centro de Investigacion Medica Aplicada (CIMA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), CIBER-ONC number CB16/12/00369, Pamplona, Spain, Pamplona, Spain., Zhao J; Bristol-Myers Squibb, Summit, New Jersey, United States., Kostopoulos IV; National and Kapodistrian University of Athens, ATHENS, Greece., Tsitsilonis O; National and Kapodistrian University of Athens, Athens, Greece., Terpos E; National and Kapodistrian University of Athens School of Medicine, Athens, Greece., Gutierrez NC; Hospital Universitario de Salamanca. IBSAL. Centro de Investigación del Cáncer, Salamanca, Spain., Fernandez M; Hospital Universitario 12 de Octubre, Madrid, Spain., Calasanz MJJ; UNIVERSITY OF NAVARRA, Pamplona, Spain., Rodriguez-Otero P; Cancer Center Clínica Universidad de Navarra, Pamplona, Spain., Prosper F; Clinica Universidad de Navarra, Pamplona, Spain., Lozano T; Centro de Investigación Médica Aplicada, CIMA, Pamplona, Spain., Lasarte JJ; Centro de Investigación Médica Aplicada, CIMA, Pamplona, Spain., Ebert BL; Dana-Farber Cancer Institute, Boston, Massachusetts, United States., Oriol A; ICO - Hosp Germans Trias i Pujol, Badalona, Spain., Sureda A; Institut Català d'Oncologia, Barcelona, Spain., Blanchard MJ; Hospital Ramon y Cajal, madrid, Spain., González-Montes Y; Hospital Josep Trueta, Girona, Spain., Bargay J; Hospital Universitario Son LLatzer, Instituto de Investigación Sanitaria Illes Balears (IdISBa),, Palma de Mallorca, Spain., Lakhwani S; Hospital Universitario de Canarias. Universidad de La Laguna., San Cristobal de La Laguna, Tenerife, Spain., Ríos-Tamayo R; Hospital Universitario Virgen de las Nieves, Granada, Spain., Rosiñol L; Hospital Clínic, IDIBAPS, Barcelona, Spain., Martínez-López J; Department of Hematology, Hospital Universitario 12 de Octubre, imas12, Universidad Complutense, Centro Nacional de Investigaciones Oncológicas, Centro de Investigación Biomédic, Madrid, Spain., Lahuerta JJ; Instituto de Investigación.Hospital Universitario 12 de Octubre, Madrid, Spain., Bladé J; Hospital Clínic i Provincial, Institut de Investicacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain., Mateos MV; Hospital Universitario de Salamanca, Instituto de Investigacion Biomedica de Salamanca, Instituto de Biologia Molecular y Celular del Cancer (Universidad de Salamanca-Consejo Superior de Investigacion, Salamanca, Spain., San-Miguel J; Cancer Center Clínica Universidad de Navarra (CCUN), Centro de Investigación Medica Aplicada (CIMA), Instituto de Investigación, Sanitaria de Navarra (IDISNA, CIBERONC), CIBER-O, Pamplona, Navarra, Spain., Cedena MT; Hospital Universitario 12 de Octubre, Madrid, Spain., Puig N; University Hospital of Salamanca, Salamanca, Spain., Hagner PR; Bristol-Myers Squibb, Summit, New Jersey, United States., Ortiz Estevez M; Bristol Myers Squibb, Sevilla, Spain., Martínez-Climent JA; Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain., Paiva B; Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada (CIMA), Instituto de Investigación Sanitaria de Navarra (IDISNA), CIBERONC (CB16/12/00369), Pamplona, Spain.
Source: Blood [Blood] 2026 Jul 24. Date of Electronic Publication: 2026 Jul 24.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: MRD dynamics predicts progression and reveals a vulnerable state for immunotherapy interception in multiple myeloma.
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  Data: <searchLink fieldCode="AU" term="%22Gonzalez+C%22">Gonzalez C</searchLink>; Cancer Center Clinica Universidad de Navarra, Centro de Investigacion Medica Aplicada (CIMA), IDISNA, CIBER-ONC number CB16/12/00369 and CB16/12/00489, Pamplona, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Guerrero+C%22">Guerrero C</searchLink>; CIMA, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Larrayoz+M%22">Larrayoz M</searchLink>; CIMA, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Zabaleta+A%22">Zabaleta A</searchLink>; Cancer Center Clinica Universidad de Navarra (CCUN), Centro de Investigacion Medica Aplicada (CIMA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), CIBER-ONC number CB16/12/00369, Pamplona, Spain, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Zhao+J%22">Zhao J</searchLink>; Bristol-Myers Squibb, Summit, New Jersey, United States.<br /><searchLink fieldCode="AU" term="%22Kostopoulos+IV%22">Kostopoulos IV</searchLink>; National and Kapodistrian University of Athens, ATHENS, Greece.<br /><searchLink fieldCode="AU" term="%22Tsitsilonis+O%22">Tsitsilonis O</searchLink>; National and Kapodistrian University of Athens, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Terpos+E%22">Terpos E</searchLink>; National and Kapodistrian University of Athens School of Medicine, Athens, Greece.<br /><searchLink fieldCode="AU" term="%22Gutierrez+NC%22">Gutierrez NC</searchLink>; Hospital Universitario de Salamanca. IBSAL. Centro de Investigación del Cáncer, Salamanca, Spain.<br /><searchLink fieldCode="AU" term="%22Fernandez+M%22">Fernandez M</searchLink>; Hospital Universitario 12 de Octubre, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Calasanz+MJJ%22">Calasanz MJJ</searchLink>; UNIVERSITY OF NAVARRA, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Rodriguez-Otero+P%22">Rodriguez-Otero P</searchLink>; Cancer Center Clínica Universidad de Navarra, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Prosper+F%22">Prosper F</searchLink>; Clinica Universidad de Navarra, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Lozano+T%22">Lozano T</searchLink>; Centro de Investigación Médica Aplicada, CIMA, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Lasarte+JJ%22">Lasarte JJ</searchLink>; Centro de Investigación Médica Aplicada, CIMA, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Ebert+BL%22">Ebert BL</searchLink>; Dana-Farber Cancer Institute, Boston, Massachusetts, United States.<br /><searchLink fieldCode="AU" term="%22Oriol+A%22">Oriol A</searchLink>; ICO - Hosp Germans Trias i Pujol, Badalona, Spain.<br /><searchLink fieldCode="AU" term="%22Sureda+A%22">Sureda A</searchLink>; Institut Català d'Oncologia, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Blanchard+MJ%22">Blanchard MJ</searchLink>; Hospital Ramon y Cajal, madrid, Spain.<br /><searchLink fieldCode="AU" term="%22González-Montes+Y%22">González-Montes Y</searchLink>; Hospital Josep Trueta, Girona, Spain.<br /><searchLink fieldCode="AU" term="%22Bargay+J%22">Bargay J</searchLink>; Hospital Universitario Son LLatzer, Instituto de Investigación Sanitaria Illes Balears (IdISBa),, Palma de Mallorca, Spain.<br /><searchLink fieldCode="AU" term="%22Lakhwani+S%22">Lakhwani S</searchLink>; Hospital Universitario de Canarias. Universidad de La Laguna., San Cristobal de La Laguna, Tenerife, Spain.<br /><searchLink fieldCode="AU" term="%22Ríos-Tamayo+R%22">Ríos-Tamayo R</searchLink>; Hospital Universitario Virgen de las Nieves, Granada, Spain.<br /><searchLink fieldCode="AU" term="%22Rosiñol+L%22">Rosiñol L</searchLink>; Hospital Clínic, IDIBAPS, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Martínez-López+J%22">Martínez-López J</searchLink>; Department of Hematology, Hospital Universitario 12 de Octubre, imas12, Universidad Complutense, Centro Nacional de Investigaciones Oncológicas, Centro de Investigación Biomédic, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Lahuerta+JJ%22">Lahuerta JJ</searchLink>; Instituto de Investigación.Hospital Universitario 12 de Octubre, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Bladé+J%22">Bladé J</searchLink>; Hospital Clínic i Provincial, Institut de Investicacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Mateos+MV%22">Mateos MV</searchLink>; Hospital Universitario de Salamanca, Instituto de Investigacion Biomedica de Salamanca, Instituto de Biologia Molecular y Celular del Cancer (Universidad de Salamanca-Consejo Superior de Investigacion, Salamanca, Spain.<br /><searchLink fieldCode="AU" term="%22San-Miguel+J%22">San-Miguel J</searchLink>; Cancer Center Clínica Universidad de Navarra (CCUN), Centro de Investigación Medica Aplicada (CIMA), Instituto de Investigación, Sanitaria de Navarra (IDISNA, CIBERONC), CIBER-O, Pamplona, Navarra, Spain.<br /><searchLink fieldCode="AU" term="%22Cedena+MT%22">Cedena MT</searchLink>; Hospital Universitario 12 de Octubre, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Puig+N%22">Puig N</searchLink>; University Hospital of Salamanca, Salamanca, Spain.<br /><searchLink fieldCode="AU" term="%22Hagner+PR%22">Hagner PR</searchLink>; Bristol-Myers Squibb, Summit, New Jersey, United States.<br /><searchLink fieldCode="AU" term="%22Ortiz+Estevez+M%22">Ortiz Estevez M</searchLink>; Bristol Myers Squibb, Sevilla, Spain.<br /><searchLink fieldCode="AU" term="%22Martínez-Climent+JA%22">Martínez-Climent JA</searchLink>; Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Paiva+B%22">Paiva B</searchLink>; Clinica Universidad de Navarra, Centro de Investigación Médica Aplicada (CIMA), Instituto de Investigación Sanitaria de Navarra (IDISNA), CIBERONC (CB16/12/00369), Pamplona, Spain.
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