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Patient-reported outcomes from the TBCRC 022 study of neratinib and ado-trastuzumab emtansine for HER2-positive breast cancer brain metastases.

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Title: Patient-reported outcomes from the TBCRC 022 study of neratinib and ado-trastuzumab emtansine for HER2-positive breast cancer brain metastases.
Authors: Grinda T; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Gustave Roussy, Medical Oncology Department, Villejuif, France., Heiling HM; Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA., Tayob N; Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA., Smith KL; Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA., Davis R; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Cotter C; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., DeMeo MK; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Santa-Maria CA; Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA., Van Poznak C; University of Michigan, Ann Arbor, MI, USA., Moy B; Harvard Medical School, Boston, MA, USA; Massachusetts General Hospital, Boston, MA, USA., Brufsky AM; UPMC Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Melisko ME; University of California at San Francisco, San Francisco, CA, USA., O'Sullivan CC; Mayo Clinic, Rochester, MN, USA., Isaacs C; MedStar/Georgetown University, Washington, DC, USA., Rauf Y; University of North Carolina, Chapel Hill, NC, USA., Nangia JR; Baylor College of Medicine, Houston, TX, USA., Burns RT; The Emmes Corporation, Rockville, MD, USA., Savoie J; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; The Emmes Corporation, Rockville, MD, USA., Wolff AC; Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA., Winer EP; Yale Cancer Center, New Haven, CT, USA., Mayer EL; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA., Tolaney SM; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA., Rimawi MF; Baylor College of Medicine, Houston, TX, USA., Ruddy KJ; Mayo Clinic, Rochester, MN, USA., Rocque G; University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham, AL, USA., Krop IE; Yale Cancer Center, New Haven, CT, USA., Lin NU; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA., Freedman RA; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address: rachel_freedman@dfci.harvard.edu.
Source: Breast (Edinburgh, Scotland) [Breast] 2026 Jul 20; Vol. 89, pp. 104881. Date of Electronic Publication: 2026 Jul 20.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9213011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-3080 (Electronic) Linking ISSN: 09609776 NLM ISO Abbreviation: Breast Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Patient-reported outcomes from the TBCRC 022 study of neratinib and ado-trastuzumab emtansine for HER2-positive breast cancer brain metastases.
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  Data: <searchLink fieldCode="AU" term="%22Grinda+T%22">Grinda T</searchLink>; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Gustave Roussy, Medical Oncology Department, Villejuif, France.<br /><searchLink fieldCode="AU" term="%22Heiling+HM%22">Heiling HM</searchLink>; Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Tayob+N%22">Tayob N</searchLink>; Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Smith+KL%22">Smith KL</searchLink>; Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Davis+R%22">Davis R</searchLink>; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cotter+C%22">Cotter C</searchLink>; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22DeMeo+MK%22">DeMeo MK</searchLink>; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Santa-Maria+CA%22">Santa-Maria CA</searchLink>; Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Van+Poznak+C%22">Van Poznak C</searchLink>; University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Moy+B%22">Moy B</searchLink>; Harvard Medical School, Boston, MA, USA; Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Brufsky+AM%22">Brufsky AM</searchLink>; UPMC Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Melisko+ME%22">Melisko ME</searchLink>; University of California at San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22O'Sullivan+CC%22">O'Sullivan CC</searchLink>; Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Isaacs+C%22">Isaacs C</searchLink>; MedStar/Georgetown University, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Rauf+Y%22">Rauf Y</searchLink>; University of North Carolina, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Nangia+JR%22">Nangia JR</searchLink>; Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Burns+RT%22">Burns RT</searchLink>; The Emmes Corporation, Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Savoie+J%22">Savoie J</searchLink>; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; The Emmes Corporation, Rockville, MD, USA.<br /><searchLink fieldCode="AU" term="%22Wolff+AC%22">Wolff AC</searchLink>; Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Winer+EP%22">Winer EP</searchLink>; Yale Cancer Center, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Mayer+EL%22">Mayer EL</searchLink>; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Tolaney+SM%22">Tolaney SM</searchLink>; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rimawi+MF%22">Rimawi MF</searchLink>; Baylor College of Medicine, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Ruddy+KJ%22">Ruddy KJ</searchLink>; Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Rocque+G%22">Rocque G</searchLink>; University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham, AL, USA.<br /><searchLink fieldCode="AU" term="%22Krop+IE%22">Krop IE</searchLink>; Yale Cancer Center, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Lin+NU%22">Lin NU</searchLink>; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Freedman+RA%22">Freedman RA</searchLink>; Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address: rachel_freedman@dfci.harvard.edu.
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  Data: <searchLink fieldCode="JN" term="%229213011%22">Breast (Edinburgh, Scotland)</searchLink> [Breast] 2026 Jul 20; Vol. 89, pp. 104881. <i>Date of Electronic Publication: </i>2026 Jul 20.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>9213011 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1532-3080 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209609776%22">09609776 </searchLink><i>NLM ISO Abbreviation: </i>Breast <i>Subsets: </i>MEDLINE
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