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Bioorthogonal epigenetic anchoring of heterochromatin to the nuclear lamina reverses senescence and osteoarthritis.

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Title: Bioorthogonal epigenetic anchoring of heterochromatin to the nuclear lamina reverses senescence and osteoarthritis.
Authors: Ren X; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, China; Central Laboratory of Renmin Hospital of Wuhan University, Wuhan, China., Zhuang H; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, China; Central Laboratory of Renmin Hospital of Wuhan University, Wuhan, China., Zhu J; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, China; Central Laboratory of Renmin Hospital of Wuhan University, Wuhan, China., Jiang H; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, China., Zhang J; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, China., Zhang Y; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, China., Feng R; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, China., Shi R; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, China., Zhang R; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, China., Li L; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, China., Adam MS; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, China., Zhou P; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, China. Electronic address: zhoupanghu@whu.edu.cn.
Source: Journal of advanced research [J Adv Res] 2026 Jul 25. Date of Electronic Publication: 2026 Jul 25.
Publication Type: Journal Article
Journal Info: Publisher: Cairo University, production and hosting by Elsevier B. V Country of Publication: Egypt NLM ID: 101546952 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2090-1224 (Electronic) Linking ISSN: 20901224 NLM ISO Abbreviation: J Adv Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Bioorthogonal epigenetic anchoring of heterochromatin to the nuclear lamina reverses senescence and osteoarthritis.
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  Data: <searchLink fieldCode="AU" term="%22Ren+X%22">Ren X</searchLink>; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, China; Central Laboratory of Renmin Hospital of Wuhan University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Zhuang+H%22">Zhuang H</searchLink>; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, China; Central Laboratory of Renmin Hospital of Wuhan University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Zhu+J%22">Zhu J</searchLink>; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, China; Central Laboratory of Renmin Hospital of Wuhan University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Jiang+H%22">Jiang H</searchLink>; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Feng+R%22">Feng R</searchLink>; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Shi+R%22">Shi R</searchLink>; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Zhang+R%22">Zhang R</searchLink>; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Adam+MS%22">Adam MS</searchLink>; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Zhou+P%22">Zhou P</searchLink>; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, China. Electronic address: zhoupanghu@whu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101546952%22">Journal of advanced research</searchLink> [J Adv Res] 2026 Jul 25. <i>Date of Electronic Publication: </i>2026 Jul 25.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cairo+University%2C+production+and+hosting+by+Elsevier+B%2E+V%22">Cairo University, production and hosting by Elsevier B. V </searchLink><i>Country of Publication: </i>Egypt <i>NLM ID: </i>101546952 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2090-1224 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220901224%22">20901224 </searchLink><i>NLM ISO Abbreviation: </i>J Adv Res <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1016/j.jare.2026.07.047
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        Text: English
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      – TitleFull: Bioorthogonal epigenetic anchoring of heterochromatin to the nuclear lamina reverses senescence and osteoarthritis.
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            – D: 25
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              Text: 2026 Jul 25
              Type: published
              Y: 2026
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