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5-hydroxymethylcytosine deposition mediates Polycomb repressive complex 2 function in MYCN-amplified neuroblastoma.

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Title: 5-hydroxymethylcytosine deposition mediates Polycomb repressive complex 2 function in MYCN-amplified neuroblastoma.
Authors: Chennakesavalu M; Division of Hematology-Oncology, Department of Pediatrics, University of Chicago, Chicago, IL, USA.; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA., Lopez GL; Division of Hematology-Oncology, Department of Pediatrics, University of Chicago, Chicago, IL, USA.; School of Medicine, Stanford University, Stanford, CA, USA., Gupta V; Division of Hematology-Oncology, Department of Pediatrics, University of Chicago, Chicago, IL, USA., Moore K; Division of Hematology-Oncology, Department of Pediatrics, University of Chicago, Chicago, IL, USA., Xue Y; Division of Hematology-Oncology, Department of Pediatrics, University of Chicago, Chicago, IL, USA., Handen A; Division of Hematology-Oncology, Department of Pediatrics, University of Chicago, Chicago, IL, USA., Majowka J; Division of Hematology-Oncology, Department of Pediatrics, University of Chicago, Chicago, IL, USA., Veeravalli S; Division of Hematology-Oncology, Department of Pediatrics, University of Chicago, Chicago, IL, USA.; Rice University, Houston, TX, USA., Borchert R; Division of Hematology-Oncology, Department of Pediatrics, University of Chicago, Chicago, IL, USA., Pomaville M; Division of Hematology-Oncology, Department of Pediatrics, University of Chicago, Chicago, IL, USA.; Children's Hospital of Philadelphia, Philadelphia, PA, USA., Chlenski A; Division of Hematology-Oncology, Department of Pediatrics, University of Chicago, Chicago, IL, USA., He C; Department of Chemistry, University of Chicago, Chicago, IL, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Piunti A; Division of Hematology-Oncology, Department of Pediatrics, University of Chicago, Chicago, IL, USA.; University of Chicago Comprehensive Cancer Center, Chicago, IL, USA., Applebaum MA; Division of Hematology-Oncology, Department of Pediatrics, University of Chicago, Chicago, IL, USA.; University of Chicago Comprehensive Cancer Center, Chicago, IL, USA.
Source: IScience [iScience] 2026 Jul 16; Vol. 29 (8), pp. 116816. Date of Electronic Publication: 2026 Jul 16 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
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  Data: 5-hydroxymethylcytosine deposition mediates Polycomb repressive complex 2 function in MYCN-amplified neuroblastoma.
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  Data: <searchLink fieldCode="AU" term="%22Chennakesavalu+M%22">Chennakesavalu M</searchLink>; Division of Hematology-Oncology, Department of Pediatrics, University of Chicago, Chicago, IL, USA.; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lopez+GL%22">Lopez GL</searchLink>; Division of Hematology-Oncology, Department of Pediatrics, University of Chicago, Chicago, IL, USA.; School of Medicine, Stanford University, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gupta+V%22">Gupta V</searchLink>; Division of Hematology-Oncology, Department of Pediatrics, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Moore+K%22">Moore K</searchLink>; Division of Hematology-Oncology, Department of Pediatrics, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Xue+Y%22">Xue Y</searchLink>; Division of Hematology-Oncology, Department of Pediatrics, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Handen+A%22">Handen A</searchLink>; Division of Hematology-Oncology, Department of Pediatrics, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Majowka+J%22">Majowka J</searchLink>; Division of Hematology-Oncology, Department of Pediatrics, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Veeravalli+S%22">Veeravalli S</searchLink>; Division of Hematology-Oncology, Department of Pediatrics, University of Chicago, Chicago, IL, USA.; Rice University, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Borchert+R%22">Borchert R</searchLink>; Division of Hematology-Oncology, Department of Pediatrics, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Pomaville+M%22">Pomaville M</searchLink>; Division of Hematology-Oncology, Department of Pediatrics, University of Chicago, Chicago, IL, USA.; Children's Hospital of Philadelphia, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Chlenski+A%22">Chlenski A</searchLink>; Division of Hematology-Oncology, Department of Pediatrics, University of Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22He+C%22">He C</searchLink>; Department of Chemistry, University of Chicago, Chicago, IL, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.<br /><searchLink fieldCode="AU" term="%22Piunti+A%22">Piunti A</searchLink>; Division of Hematology-Oncology, Department of Pediatrics, University of Chicago, Chicago, IL, USA.; University of Chicago Comprehensive Cancer Center, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Applebaum+MA%22">Applebaum MA</searchLink>; Division of Hematology-Oncology, Department of Pediatrics, University of Chicago, Chicago, IL, USA.; University of Chicago Comprehensive Cancer Center, Chicago, IL, USA.
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