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Systematic Benchmarking of CRISPR-Cas9 Off-Target Prediction Tools Reveals Limitations and Implications for Preclinical Assessment.

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Title: Systematic Benchmarking of CRISPR-Cas9 Off-Target Prediction Tools Reveals Limitations and Implications for Preclinical Assessment.
Authors: Kaufmann MM; Institute for Transfusion Medicine and Gene Therapy, Medical Center-University of Freiburg, Freiburg, Germany., Hackenberg M; Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany., Jobson Pargeter W; Bioinformatics Group, Department of Computer Science, University of Freiburg, Freiburg, Germany., Backofen R; Bioinformatics Group, Department of Computer Science, University of Freiburg, Freiburg, Germany.; Signalling Research Centre CIBSS, University of Freiburg, Freiburg, Germany., Binder H; Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany., Cathomen T; Institute for Transfusion Medicine and Gene Therapy, Medical Center-University of Freiburg, Freiburg, Germany.; Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Center for Cell and Gene Therapy, Freiburg, Germany.
Source: Human gene therapy [Hum Gene Ther] 2026 Jul 26, pp. 10430342261466407. Date of Electronic Publication: 2026 Jul 26.
Publication Type: Journal Article
Journal Info: Publisher: M.A. Liebert Country of Publication: United States NLM ID: 9008950 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-7422 (Electronic) Linking ISSN: 10430342 NLM ISO Abbreviation: Hum Gene Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Systematic Benchmarking of CRISPR-Cas9 Off-Target Prediction Tools Reveals Limitations and Implications for Preclinical Assessment.
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  Data: <searchLink fieldCode="AU" term="%22Kaufmann+MM%22">Kaufmann MM</searchLink>; Institute for Transfusion Medicine and Gene Therapy, Medical Center-University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hackenberg+M%22">Hackenberg M</searchLink>; Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Jobson+Pargeter+W%22">Jobson Pargeter W</searchLink>; Bioinformatics Group, Department of Computer Science, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Backofen+R%22">Backofen R</searchLink>; Bioinformatics Group, Department of Computer Science, University of Freiburg, Freiburg, Germany.; Signalling Research Centre CIBSS, University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Binder+H%22">Binder H</searchLink>; Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Cathomen+T%22">Cathomen T</searchLink>; Institute for Transfusion Medicine and Gene Therapy, Medical Center-University of Freiburg, Freiburg, Germany.; Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Center for Cell and Gene Therapy, Freiburg, Germany.
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  Data: <searchLink fieldCode="JN" term="%229008950%22">Human gene therapy</searchLink> [Hum Gene Ther] 2026 Jul 26, pp. 10430342261466407. <i>Date of Electronic Publication: </i>2026 Jul 26.
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