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Disentangling Sex Differences in Sulfonylurea Drug Response With Genome-Wide Association Studies in Individuals With Type 2 Diabetes.

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Title: Disentangling Sex Differences in Sulfonylurea Drug Response With Genome-Wide Association Studies in Individuals With Type 2 Diabetes.
Authors: Breeyear JH; Biostatistics and Computational Biology Branch, National Institute for Environmental Health Sciences, National Institutes of Health, Durham, North Carolina, USA., House JS; Biostatistics and Computational Biology Branch, National Institute for Environmental Health Sciences, National Institutes of Health, Durham, North Carolina, USA., Kvale M; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, USA., Nam S; Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA., Akhtari FS; Biostatistics and Computational Biology Branch, National Institute for Environmental Health Sciences, National Institutes of Health, Durham, North Carolina, USA., Shah HS; Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts, USA., Hedderson MM; Division of Research, Kaiser Permanente Northern California, Oakland, California, USA., Giacomini KM; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, USA., Mychaleckyj JC; Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA., Doria A; Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts, USA., Wagner MJ; Center for Pharmacogenomics and Individualized Therapy, UNC, Chapel Hill, North Carolina, USA., Li JH; Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.; Diabetes Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA., Yee SW; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, USA., Buse JB; Division of Endocrinology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA., Woychik RP; Office of the Director, National Institute for Environmental Health Sciences, National Institutes of Health, Durham, North Carolina, USA., Rotroff DM; Department of Quantitative Health Sciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA.; Center for Quantitative Metabolic Research, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA.; Department of Endocrinology and Metabolism, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA., Motsinger-Reif AA; Biostatistics and Computational Biology Branch, National Institute for Environmental Health Sciences, National Institutes of Health, Durham, North Carolina, USA.
Source: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2026 Jul 27. Date of Electronic Publication: 2026 Jul 27.
Publication Type: Journal Article
Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Breeyear+JH%22">Breeyear JH</searchLink>; Biostatistics and Computational Biology Branch, National Institute for Environmental Health Sciences, National Institutes of Health, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22House+JS%22">House JS</searchLink>; Biostatistics and Computational Biology Branch, National Institute for Environmental Health Sciences, National Institutes of Health, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Kvale+M%22">Kvale M</searchLink>; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Nam+S%22">Nam S</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Akhtari+FS%22">Akhtari FS</searchLink>; Biostatistics and Computational Biology Branch, National Institute for Environmental Health Sciences, National Institutes of Health, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Shah+HS%22">Shah HS</searchLink>; Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Hedderson+MM%22">Hedderson MM</searchLink>; Division of Research, Kaiser Permanente Northern California, Oakland, California, USA.<br /><searchLink fieldCode="AU" term="%22Giacomini+KM%22">Giacomini KM</searchLink>; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Mychaleckyj+JC%22">Mychaleckyj JC</searchLink>; Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA.<br /><searchLink fieldCode="AU" term="%22Doria+A%22">Doria A</searchLink>; Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Wagner+MJ%22">Wagner MJ</searchLink>; Center for Pharmacogenomics and Individualized Therapy, UNC, Chapel Hill, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Li+JH%22">Li JH</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.; Diabetes Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Yee+SW%22">Yee SW</searchLink>; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Buse+JB%22">Buse JB</searchLink>; Division of Endocrinology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Woychik+RP%22">Woychik RP</searchLink>; Office of the Director, National Institute for Environmental Health Sciences, National Institutes of Health, Durham, North Carolina, USA.<br /><searchLink fieldCode="AU" term="%22Rotroff+DM%22">Rotroff DM</searchLink>; Department of Quantitative Health Sciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA.; Center for Quantitative Metabolic Research, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA.; Department of Endocrinology and Metabolism, Cleveland Clinic Research, Cleveland Clinic, Cleveland, Ohio, USA.<br /><searchLink fieldCode="AU" term="%22Motsinger-Reif+AA%22">Motsinger-Reif AA</searchLink>; Biostatistics and Computational Biology Branch, National Institute for Environmental Health Sciences, National Institutes of Health, Durham, North Carolina, USA.
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