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Smooth muscle cell spheroids as 3D model of phenotypic plasticity and matrix deposition revealed by 2D-3D proteomics.

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Title: Smooth muscle cell spheroids as 3D model of phenotypic plasticity and matrix deposition revealed by 2D-3D proteomics.
Authors: Hesse J; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. Julia.Hesse@hhu.de.; Department of Molecular Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. Julia.Hesse@hhu.de.; CARID, Cardiovascular Research Institute Düsseldorf, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. Julia.Hesse@hhu.de., Resch U; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; Centre of Physiology and Pharmacology, Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Vienna, Austria., Görtz L; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Lang S; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Batool R; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Saradar S; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Schoof P; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Gehlweiler K; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Zouikova D; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Jashnieh P; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Fernandes Velosa R; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Hotzel-Hacker N; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Suzuki F; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Bayraktar S; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Cappallo M; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Schmidt V; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Ebbert L; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Bülow MH; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Kucharowski N; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Laakkonen EK; Gerontology Research Centre, Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland., Krüger M; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, Cologne, Germany., Sengle G; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Department of Pediatrics and Adolescent Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Center for Biochemistry, Faculty of Medicine, University Hospital of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Cologne Center for Musculoskeletal Biomechanics (CCMB), Cologne, Germany., Chadt A; Medical Faculty, Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Munich, Germany., Lichtenberg A; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; CARID, Cardiovascular Research Institute Düsseldorf, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Aubin H; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; CARID, Cardiovascular Research Institute Düsseldorf, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Weber E; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. Elvira.Weber@med.uni-duesseldorf.de.; CARID, Cardiovascular Research Institute Düsseldorf, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. Elvira.Weber@med.uni-duesseldorf.de.
Source: Scientific reports [Sci Rep] 2026 Jul 27; Vol. 16 (1). Date of Electronic Publication: 2026 Jul 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Smooth muscle cell spheroids as 3D model of phenotypic plasticity and matrix deposition revealed by 2D-3D proteomics.
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  Data: <searchLink fieldCode="AU" term="%22Hesse+J%22">Hesse J</searchLink>; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. Julia.Hesse@hhu.de.; Department of Molecular Cardiology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. Julia.Hesse@hhu.de.; CARID, Cardiovascular Research Institute Düsseldorf, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. Julia.Hesse@hhu.de.<br /><searchLink fieldCode="AU" term="%22Resch+U%22">Resch U</searchLink>; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; Centre of Physiology and Pharmacology, Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Görtz+L%22">Görtz L</searchLink>; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Lang+S%22">Lang S</searchLink>; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Batool+R%22">Batool R</searchLink>; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Saradar+S%22">Saradar S</searchLink>; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Schoof+P%22">Schoof P</searchLink>; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Gehlweiler+K%22">Gehlweiler K</searchLink>; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Zouikova+D%22">Zouikova D</searchLink>; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Jashnieh+P%22">Jashnieh P</searchLink>; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Fernandes+Velosa+R%22">Fernandes Velosa R</searchLink>; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Hotzel-Hacker+N%22">Hotzel-Hacker N</searchLink>; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Suzuki+F%22">Suzuki F</searchLink>; 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Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Bülow+MH%22">Bülow MH</searchLink>; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Kucharowski+N%22">Kucharowski N</searchLink>; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Laakkonen+EK%22">Laakkonen EK</searchLink>; Gerontology Research Centre, Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.<br /><searchLink fieldCode="AU" term="%22Krüger+M%22">Krüger M</searchLink>; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Sengle+G%22">Sengle G</searchLink>; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.; Department of Pediatrics and Adolescent Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Center for Biochemistry, Faculty of Medicine, University Hospital of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.; Cologne Center for Musculoskeletal Biomechanics (CCMB), Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Chadt+A%22">Chadt A</searchLink>; Medical Faculty, Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Lichtenberg+A%22">Lichtenberg A</searchLink>; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; CARID, Cardiovascular Research Institute Düsseldorf, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Aubin+H%22">Aubin H</searchLink>; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; CARID, Cardiovascular Research Institute Düsseldorf, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.<br /><searchLink fieldCode="AU" term="%22Weber+E%22">Weber E</searchLink>; Research Group 3D Cardiovascular Regenerative Medicine and Tissue Engineering (CURE 3D), Department of Cardiac Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. Elvira.Weber@med.uni-duesseldorf.de.; CARID, Cardiovascular Research Institute Düsseldorf, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. Elvira.Weber@med.uni-duesseldorf.de.
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