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The current landscape of mRNA therapy and the strategies for mRNA purification and dsRNA removal.

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Title: The current landscape of mRNA therapy and the strategies for mRNA purification and dsRNA removal.
Authors: Liu JH; Center for Tissue Engineering and Stem Cell Research, Translation Medicine Research Center，Guizhou Biomanufacturing Laboratory, Guizhou Medical University, Guiyang, 561113, China.; Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119074, Singapore., Zang J; Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119074, Singapore.; Tianfu Yongxing Laboratory, Chengdu, 610213, China., Xu JR; Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119074, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 119074, Singapore., Ran XB; Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119074, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 119074, Singapore., Su M; Center for Tissue Engineering and Stem Cell Research, Translation Medicine Research Center，Guizhou Biomanufacturing Laboratory, Guizhou Medical University, Guiyang, 561113, China., Zhang WM; Central Laboratory, Beijing Jishuitan Hospital Guizhou Hospital, Guiyang, 550014, China., Ge ZW; Department of Laboratory Medicine, Guizhou Provincial People's Hospital, Affiliated Hospital of Guizhou University, Guiyang, 550002, China., Sun QY; Department of Neurology, National Neuroscience Institute, Singapore, Singapore. Qiaoyangsun@gmail.com., Ding LW; Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119074, Singapore. patdl@nus.edu.sg.; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 119074, Singapore. patdl@nus.edu.sg.
Source: Journal of biomedical science [J Biomed Sci] 2026 Jul 27; Vol. 33 (1). Date of Electronic Publication: 2026 Jul 27.
Publication Type: Journal Article; Review
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 9421567 Publication Model: Electronic Cited Medium: Internet ISSN: 1423-0127 (Electronic) Linking ISSN: 10217770 NLM ISO Abbreviation: J Biomed Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The current landscape of mRNA therapy and the strategies for mRNA purification and dsRNA removal.
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  Data: <searchLink fieldCode="AU" term="%22Liu+JH%22">Liu JH</searchLink>; Center for Tissue Engineering and Stem Cell Research, Translation Medicine Research Center，Guizhou Biomanufacturing Laboratory, Guizhou Medical University, Guiyang, 561113, China.; Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119074, Singapore.<br /><searchLink fieldCode="AU" term="%22Zang+J%22">Zang J</searchLink>; Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119074, Singapore.; Tianfu Yongxing Laboratory, Chengdu, 610213, China.<br /><searchLink fieldCode="AU" term="%22Xu+JR%22">Xu JR</searchLink>; Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119074, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 119074, Singapore.<br /><searchLink fieldCode="AU" term="%22Ran+XB%22">Ran XB</searchLink>; Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119074, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 119074, Singapore.<br /><searchLink fieldCode="AU" term="%22Su+M%22">Su M</searchLink>; Center for Tissue Engineering and Stem Cell Research, Translation Medicine Research Center，Guizhou Biomanufacturing Laboratory, Guizhou Medical University, Guiyang, 561113, China.<br /><searchLink fieldCode="AU" term="%22Zhang+WM%22">Zhang WM</searchLink>; Central Laboratory, Beijing Jishuitan Hospital Guizhou Hospital, Guiyang, 550014, China.<br /><searchLink fieldCode="AU" term="%22Ge+ZW%22">Ge ZW</searchLink>; Department of Laboratory Medicine, Guizhou Provincial People's Hospital, Affiliated Hospital of Guizhou University, Guiyang, 550002, China.<br /><searchLink fieldCode="AU" term="%22Sun+QY%22">Sun QY</searchLink>; Department of Neurology, National Neuroscience Institute, Singapore, Singapore. Qiaoyangsun@gmail.com.<br /><searchLink fieldCode="AU" term="%22Ding+LW%22">Ding LW</searchLink>; Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119074, Singapore. patdl@nus.edu.sg.; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 119074, Singapore. patdl@nus.edu.sg.
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  Data: <searchLink fieldCode="JN" term="%229421567%22">Journal of biomedical science</searchLink> [J Biomed Sci] 2026 Jul 27; Vol. 33 (1). <i>Date of Electronic Publication: </i>2026 Jul 27.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9421567 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1423-0127 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210217770%22">10217770 </searchLink><i>NLM ISO Abbreviation: </i>J Biomed Sci <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s12929-026-01277-4
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        Text: English
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              Text: 2026 Jul 27
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