The current landscape of mRNA therapy and the strategies for mRNA purification and dsRNA removal.

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Title: The current landscape of mRNA therapy and the strategies for mRNA purification and dsRNA removal.
Authors: Liu JH; Center for Tissue Engineering and Stem Cell Research, Translation Medicine Research Center,Guizhou Biomanufacturing Laboratory, Guizhou Medical University, Guiyang, 561113, China.; Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119074, Singapore., Zang J; Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119074, Singapore.; Tianfu Yongxing Laboratory, Chengdu, 610213, China., Xu JR; Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119074, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 119074, Singapore., Ran XB; Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119074, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 119074, Singapore., Su M; Center for Tissue Engineering and Stem Cell Research, Translation Medicine Research Center,Guizhou Biomanufacturing Laboratory, Guizhou Medical University, Guiyang, 561113, China., Zhang WM; Central Laboratory, Beijing Jishuitan Hospital Guizhou Hospital, Guiyang, 550014, China., Ge ZW; Department of Laboratory Medicine, Guizhou Provincial People's Hospital, Affiliated Hospital of Guizhou University, Guiyang, 550002, China., Sun QY; Department of Neurology, National Neuroscience Institute, Singapore, Singapore. Qiaoyangsun@gmail.com., Ding LW; Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 119074, Singapore. patdl@nus.edu.sg.; Cancer Science Institute of Singapore, National University of Singapore, Singapore, 119074, Singapore. patdl@nus.edu.sg.
Source: Journal of biomedical science [J Biomed Sci] 2026 Jul 27; Vol. 33 (1). Date of Electronic Publication: 2026 Jul 27.
Publication Type: Journal Article; Review
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 9421567 Publication Model: Electronic Cited Medium: Internet ISSN: 1423-0127 (Electronic) Linking ISSN: 10217770 NLM ISO Abbreviation: J Biomed Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1423-0127
DOI:10.1186/s12929-026-01277-4