Core2Edge: a human glioblastoma organoid-brain slice model capturing infiltration and transcriptional heterogeneity from core to single-cell dispersion.
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| Title: | Core2Edge: a human glioblastoma organoid-brain slice model capturing infiltration and transcriptional heterogeneity from core to single-cell dispersion. |
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| Authors: | Melhem A; Department of Neurosurgery, University of Bonn, University Hospital Bonn, Bonn, Germany.; Brain Tumor Translational Research Group, University of Bonn, University Hospital Bonn, Bonn, Germany., Pregler BEF; Department of Neurosurgery, University of Bonn, University Hospital Bonn, Bonn, Germany.; Brain Tumor Translational Research Group, University of Bonn, University Hospital Bonn, Bonn, Germany., Rodriguez-Gatica JE; Functional Neuroconnectomics Group, Institute for Experimental Epileptology and Cognition Research, University of Bonn, University Hospital Bonn, Bonn, Germany., Friker LL; Brain Tumor Translational Research Group, University of Bonn, University Hospital Bonn, Bonn, Germany.; Institute of Experimental Oncology, University of Bonn, University Hospital Bonn, Bonn, Germany.; Institute of Neuropathology, University of Bonn, University Hospital Bonn, Bonn, Germany., Thomas J; Biology of Inflammation, Life & Medical Sciences Institute, University of Bonn, Bonn, Germany., Toma MI; Department of Pathology, University Hospital Bonn, Bonn, Germany., Westhoff MA; German Center for Child and Adolescent Health (DZKJ), partner site Ulm, Ulm, Germany., Ravi VM; Department of Neurosurgery, Medical Center, University of Freiburg, Freiburg, Germany.; Faculty of Medicine, Freiburg University, Freiburg, Germany.; 3D Brain Models Lab for Neurodegenerative Diseases, Department of Neurosurgery, Medical Center-University of Freiburg, Freiburg, Germany., Borger V; Department of Neurosurgery, University of Bonn, University Hospital Bonn, Bonn, Germany., Heiland DH; Department of Neurosurgery, Medical Center, University of Freiburg, Freiburg, Germany.; Faculty of Medicine, Freiburg University, Freiburg, Germany.; Microenvironment and Immunology Research Laboratory, Medical Center-University of Freiburg, Freiburg, Germany.; Translational NeuroOncology Research Group, Medical Center-University of Freiburg, Freiburg, Germany.; Department of Neurosurgery, University Hospital Erlangen, Erlangen, Germany., Layer JP; Brain Tumor Translational Research Group, University of Bonn, University Hospital Bonn, Bonn, Germany.; Institute of Experimental Oncology, University of Bonn, University Hospital Bonn, Bonn, Germany.; Department of Radiotherapy and Radiation Oncology, University of Bonn, University Hospital Bonn, Bonn, Germany., Schlitzer A; Biology of Inflammation, Life & Medical Sciences Institute, University of Bonn, Bonn, Germany., Pietsch T; Institute of Neuropathology, University of Bonn, University Hospital Bonn, Bonn, Germany., Hölzel M; Institute of Experimental Oncology, University of Bonn, University Hospital Bonn, Bonn, Germany., Waha A; Institute of Neuropathology, University of Bonn, University Hospital Bonn, Bonn, Germany., Vatter H; Department of Neurosurgery, University of Bonn, University Hospital Bonn, Bonn, Germany., Schwarz MK; Functional Neuroconnectomics Group, Institute for Experimental Epileptology and Cognition Research, University of Bonn, University Hospital Bonn, Bonn, Germany., Herrlinger U; Brain Tumor Translational Research Group, University of Bonn, University Hospital Bonn, Bonn, Germany.; Department of Neurooncology, Center for Neurology, University of Bonn, University Hospital Bonn, Bonn, Germany., Kubitscheck U; Clausius Institute of Physical and Theoretical Chemistry, University of Bonn, Bonn, Germany., Potthoff AL; Department of Neurosurgery, University of Bonn, University Hospital Bonn, Bonn, Germany.; Brain Tumor Translational Research Group, University of Bonn, University Hospital Bonn, Bonn, Germany., Schneider M; Department of Neurosurgery, University of Bonn, University Hospital Bonn, Bonn, Germany. matthias.schneider@ukbonn.de.; Brain Tumor Translational Research Group, University of Bonn, University Hospital Bonn, Bonn, Germany. matthias.schneider@ukbonn.de. |
| Source: | Nature protocols [Nat Protoc] 2026 Jul 28. Date of Electronic Publication: 2026 Jul 28. |
| Publication Type: | Journal Article; Review |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101284307 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1750-2799 (Electronic) Linking ISSN: 17502799 NLM ISO Abbreviation: Nat Protoc Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 42521807 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Core2Edge: a human glioblastoma organoid-brain slice model capturing infiltration and transcriptional heterogeneity from core to single-cell dispersion. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Melhem+A%22">Melhem A</searchLink>; Department of Neurosurgery, University of Bonn, University Hospital Bonn, Bonn, Germany.; Brain Tumor Translational Research Group, University of Bonn, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Pregler+BEF%22">Pregler BEF</searchLink>; Department of Neurosurgery, University of Bonn, University Hospital Bonn, Bonn, Germany.; Brain Tumor Translational Research Group, University of Bonn, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Rodriguez-Gatica+JE%22">Rodriguez-Gatica JE</searchLink>; Functional Neuroconnectomics Group, Institute for Experimental Epileptology and Cognition Research, University of Bonn, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Friker+LL%22">Friker LL</searchLink>; Brain Tumor Translational Research Group, University of Bonn, University Hospital Bonn, Bonn, Germany.; Institute of Experimental Oncology, University of Bonn, University Hospital Bonn, Bonn, Germany.; Institute of Neuropathology, University of Bonn, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Thomas+J%22">Thomas J</searchLink>; Biology of Inflammation, Life & Medical Sciences Institute, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Toma+MI%22">Toma MI</searchLink>; Department of Pathology, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Westhoff+MA%22">Westhoff MA</searchLink>; German Center for Child and Adolescent Health (DZKJ), partner site Ulm, Ulm, Germany.<br /><searchLink fieldCode="AU" term="%22Ravi+VM%22">Ravi VM</searchLink>; Department of Neurosurgery, Medical Center, University of Freiburg, Freiburg, Germany.; Faculty of Medicine, Freiburg University, Freiburg, Germany.; 3D Brain Models Lab for Neurodegenerative Diseases, Department of Neurosurgery, Medical Center-University of Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Borger+V%22">Borger V</searchLink>; Department of Neurosurgery, University of Bonn, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Heiland+DH%22">Heiland DH</searchLink>; Department of Neurosurgery, Medical Center, University of Freiburg, Freiburg, Germany.; Faculty of Medicine, Freiburg University, Freiburg, Germany.; Microenvironment and Immunology Research Laboratory, Medical Center-University of Freiburg, Freiburg, Germany.; Translational NeuroOncology Research Group, Medical Center-University of Freiburg, Freiburg, Germany.; Department of Neurosurgery, University Hospital Erlangen, Erlangen, Germany.<br /><searchLink fieldCode="AU" term="%22Layer+JP%22">Layer JP</searchLink>; Brain Tumor Translational Research Group, University of Bonn, University Hospital Bonn, Bonn, Germany.; Institute of Experimental Oncology, University of Bonn, University Hospital Bonn, Bonn, Germany.; Department of Radiotherapy and Radiation Oncology, University of Bonn, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Schlitzer+A%22">Schlitzer A</searchLink>; Biology of Inflammation, Life & Medical Sciences Institute, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Pietsch+T%22">Pietsch T</searchLink>; Institute of Neuropathology, University of Bonn, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Hölzel+M%22">Hölzel M</searchLink>; Institute of Experimental Oncology, University of Bonn, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Waha+A%22">Waha A</searchLink>; Institute of Neuropathology, University of Bonn, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Vatter+H%22">Vatter H</searchLink>; Department of Neurosurgery, University of Bonn, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Schwarz+MK%22">Schwarz MK</searchLink>; Functional Neuroconnectomics Group, Institute for Experimental Epileptology and Cognition Research, University of Bonn, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Herrlinger+U%22">Herrlinger U</searchLink>; Brain Tumor Translational Research Group, University of Bonn, University Hospital Bonn, Bonn, Germany.; Department of Neurooncology, Center for Neurology, University of Bonn, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Kubitscheck+U%22">Kubitscheck U</searchLink>; Clausius Institute of Physical and Theoretical Chemistry, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Potthoff+AL%22">Potthoff AL</searchLink>; Department of Neurosurgery, University of Bonn, University Hospital Bonn, Bonn, Germany.; Brain Tumor Translational Research Group, University of Bonn, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Schneider+M%22">Schneider M</searchLink>; Department of Neurosurgery, University of Bonn, University Hospital Bonn, Bonn, Germany. matthias.schneider@ukbonn.de.; Brain Tumor Translational Research Group, University of Bonn, University Hospital Bonn, Bonn, Germany. matthias.schneider@ukbonn.de. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101284307%22">Nature protocols</searchLink> [Nat Protoc] 2026 Jul 28. <i>Date of Electronic Publication: </i>2026 Jul 28. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; 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Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101284307 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1750-2799 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217502799%22">17502799 </searchLink><i>NLM ISO Abbreviation: </i>Nat Protoc <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=42521807 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41596-026-01412-3 Languages: – Code: eng Text: English Titles: – TitleFull: Core2Edge: a human glioblastoma organoid-brain slice model capturing infiltration and transcriptional heterogeneity from core to single-cell dispersion. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Melhem A – PersonEntity: Name: NameFull: Pregler BEF – PersonEntity: Name: NameFull: Rodriguez-Gatica JE – PersonEntity: Name: NameFull: Friker LL – PersonEntity: Name: NameFull: Thomas J – PersonEntity: Name: NameFull: Toma MI – PersonEntity: Name: NameFull: Westhoff MA – PersonEntity: Name: NameFull: Ravi VM – PersonEntity: Name: NameFull: Borger V – PersonEntity: Name: NameFull: Heiland DH – PersonEntity: Name: NameFull: Layer JP – PersonEntity: Name: NameFull: Schlitzer A – PersonEntity: Name: NameFull: Pietsch T – PersonEntity: Name: NameFull: Hölzel M – PersonEntity: Name: NameFull: Waha A – PersonEntity: Name: NameFull: Vatter H – PersonEntity: Name: NameFull: Schwarz MK – PersonEntity: Name: NameFull: Herrlinger U – PersonEntity: Name: NameFull: Kubitscheck U – PersonEntity: Name: NameFull: Potthoff AL – PersonEntity: Name: NameFull: Schneider M IsPartOfRelationships: – BibEntity: Dates: – D: 28 M: 07 Text: 2026 Jul 28 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1750-2799 Titles: – TitleFull: Nature protocols Type: main |
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