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Chemotherapy induces tissue NAD+ loss, and downregulation of NAD+ biosynthetic enzyme Nrk2 marks muscle wasting.

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Title: Chemotherapy induces tissue NAD+ loss, and downregulation of NAD+ biosynthetic enzyme Nrk2 marks muscle wasting.
Authors: Pöllänen N; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Gammon CJ; Department of Pathology, University of Colorado Anschutz, Aurora, CO 80045 USA., Pin F; Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN 46202 USA.; Simon Comprehensive Cancer Center, Indianapolis, IN 46202 USA., Huot JR; Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN 46202 USA.; Simon Comprehensive Cancer Center, Indianapolis, IN 46202 USA., Sartori R; Department of Biomedical Sciences, University of Padova, Padova, Italy.; Veneto Institute of Molecular Medicine, Padova, Italy., Penna F; Experimental Medicine and Clinical Pathology Unit, Department of Clinical and Biological Sciences, University of Torino, Turin, Italy., Hulmi J; Faculty of Sport and Health Sciences, NeuroMuscular Research Center, University of Jyväskylä, Jyväskylä, Finland., Bonetto A; Department of Pathology, University of Colorado Anschutz, Aurora, CO 80045 USA.; University of Colorado Cancer Center, Aurora, CO 80045 USA., Pirinen E; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Research Unit of Biomedicine and Internal Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland.; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.; Biocenter Oulu, University of Oulu, Oulu, Finland.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Jul 13. Date of Electronic Publication: 2026 Jul 13.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Chemotherapy induces tissue NAD<superscript>+</superscript> loss, and downregulation of NAD<superscript>+</superscript> biosynthetic enzyme Nrk2 marks muscle wasting.
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  Data: <searchLink fieldCode="AU" term="%22Pöllänen+N%22">Pöllänen N</searchLink>; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Gammon+CJ%22">Gammon CJ</searchLink>; Department of Pathology, University of Colorado Anschutz, Aurora, CO 80045 USA.<br /><searchLink fieldCode="AU" term="%22Pin+F%22">Pin F</searchLink>; Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN 46202 USA.; Simon Comprehensive Cancer Center, Indianapolis, IN 46202 USA.<br /><searchLink fieldCode="AU" term="%22Huot+JR%22">Huot JR</searchLink>; Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN 46202 USA.; Simon Comprehensive Cancer Center, Indianapolis, IN 46202 USA.<br /><searchLink fieldCode="AU" term="%22Sartori+R%22">Sartori R</searchLink>; Department of Biomedical Sciences, University of Padova, Padova, Italy.; Veneto Institute of Molecular Medicine, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Penna+F%22">Penna F</searchLink>; Experimental Medicine and Clinical Pathology Unit, Department of Clinical and Biological Sciences, University of Torino, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Hulmi+J%22">Hulmi J</searchLink>; Faculty of Sport and Health Sciences, NeuroMuscular Research Center, University of Jyväskylä, Jyväskylä, Finland.<br /><searchLink fieldCode="AU" term="%22Bonetto+A%22">Bonetto A</searchLink>; Department of Pathology, University of Colorado Anschutz, Aurora, CO 80045 USA.; University of Colorado Cancer Center, Aurora, CO 80045 USA.<br /><searchLink fieldCode="AU" term="%22Pirinen+E%22">Pirinen E</searchLink>; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Research Unit of Biomedicine and Internal Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland.; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.; Biocenter Oulu, University of Oulu, Oulu, Finland.
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  Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2026 Jul 13. <i>Date of Electronic Publication: </i>2026 Jul 13.
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  Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101680187 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2692-8205 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226928205%22">26928205 </searchLink><i>NLM ISO Abbreviation: </i>bioRxiv <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.64898/2026.07.11.736679
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        Text: English
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              Text: 2026 Jul 13
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