Chemotherapy induces tissue NAD+ loss, and downregulation of NAD+ biosynthetic enzyme Nrk2 marks muscle wasting.
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| Title: | Chemotherapy induces tissue NAD+ loss, and downregulation of NAD+ biosynthetic enzyme Nrk2 marks muscle wasting. |
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| Authors: | Pöllänen N; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Gammon CJ; Department of Pathology, University of Colorado Anschutz, Aurora, CO 80045 USA., Pin F; Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN 46202 USA.; Simon Comprehensive Cancer Center, Indianapolis, IN 46202 USA., Huot JR; Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, IN 46202 USA.; Simon Comprehensive Cancer Center, Indianapolis, IN 46202 USA., Sartori R; Department of Biomedical Sciences, University of Padova, Padova, Italy.; Veneto Institute of Molecular Medicine, Padova, Italy., Penna F; Experimental Medicine and Clinical Pathology Unit, Department of Clinical and Biological Sciences, University of Torino, Turin, Italy., Hulmi J; Faculty of Sport and Health Sciences, NeuroMuscular Research Center, University of Jyväskylä, Jyväskylä, Finland., Bonetto A; Department of Pathology, University of Colorado Anschutz, Aurora, CO 80045 USA.; University of Colorado Cancer Center, Aurora, CO 80045 USA., Pirinen E; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Research Unit of Biomedicine and Internal Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland.; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.; Biocenter Oulu, University of Oulu, Oulu, Finland. |
| Source: | BioRxiv : the preprint server for biology [bioRxiv] 2026 Jul 13. Date of Electronic Publication: 2026 Jul 13. |
| Publication Type: | Journal Article; Preprint |
| Journal Info: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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