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Gut microbiota restricts intestinal lipid uptake via modulation of bile phosphatidylcholine metabolism in mice.

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Title: Gut microbiota restricts intestinal lipid uptake via modulation of bile phosphatidylcholine metabolism in mice.
Authors: Brunner S; Institute of Clinical Chemistry and Laboratory Medicine, Functional Lipidomics and Metabolism Research, University Hospital Regensburg, Regensburg, Germany., Plagge J; ZIEL Institute for Food and Health, Research Group Lipid Metabolism, Technical University of Munich, Freising, Germany., Zimmermann-Kogadeeva M; Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Höring M; Institute of Clinical Chemistry and Laboratory Medicine, Functional Lipidomics and Metabolism Research, University Hospital Regensburg, Regensburg, Germany., Liebisch G; Institute of Clinical Chemistry and Laboratory Medicine, Functional Lipidomics and Metabolism Research, University Hospital Regensburg, Regensburg, Germany., Basic M; Institute for Laboratory Animal Science, Hannover Medical School, Hannover, Germany., Bolsega S; Institute for Laboratory Animal Science, Hannover Medical School, Hannover, Germany., Janssen KP; Department of Surgery, School of Medicine and Health, University Hospital rechts der Isar, Technical University of Munich, Munich, Germany., Slack E; Laboratory for Food Immunology, ETH Zürich, Zürich, Switzerland., von Gamm S; Institute of Clinical Chemistry and Laboratory Medicine, Functional Lipidomics and Metabolism Research, University Hospital Regensburg, Regensburg, Germany., Viehof-Beckmann A; Functional Microbiome Research Group, Institute of Medical Microbiology, Rheinisch-Westfälische Technische Hochschule Aachen University Hospital, Aachen, Germany., Clavel T; Functional Microbiome Research Group, Institute of Medical Microbiology, Rheinisch-Westfälische Technische Hochschule Aachen University Hospital, Aachen, Germany., Zimmermann M; Molecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Heeren J; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Giansanti P; Bavarian Center for Biomolecular Mass Spectrometry at the University Hospital rechts der Isar, Technical University of Munich, Munich, Germany., Weiss AS; Max von Pettenkofer Institute of Hygiene and Medical Microbiology, Faculty of Medicine, Munich, Germany., Hermeling S; Institute of Clinical Chemistry and Laboratory Medicine, Functional Lipidomics and Metabolism Research, University Hospital Regensburg, Regensburg, Germany., Dupont A; Institute of Medical Microbiology, Rheinisch-Westfälische Technische Hochschule Aachen University Hospital, Aachen, Germany., Ullrich AL; Institute of Medical Microbiology, Rheinisch-Westfälische Technische Hochschule Aachen University Hospital, Aachen, Germany., Jokisch F; Department of Surgery, School of Medicine and Health, University Hospital rechts der Isar, Technical University of Munich, Munich, Germany., Seeliger C; ZIEL Institute for Food and Health, Research Group Lipid Metabolism, Technical University of Munich, Freising, Germany., Bleich A; Institute for Laboratory Animal Science, Hannover Medical School, Hannover, Germany., Hidrobo M; ZIEL Institute for Food and Health, Research Group Lipid Metabolism, Technical University of Munich, Freising, Germany., Stecher B; Max von Pettenkofer Institute of Hygiene and Medical Microbiology, Faculty of Medicine, Munich, Germany.; Partner site LMU Munich, German Center for Infection Research, Munich, Germany.; Chair of Intestinal Microbiome, School of Life Sciences, Technical University of Munich, Freising, Germany., Coleman OI; Department of Nutrition and Immunology, Technical University of Munich, Freising, Germany., Moresi C; Laboratory for Food Immunology, ETH Zürich, Zürich, Switzerland., Greter G; Laboratory for Food Immunology, ETH Zürich, Zürich, Switzerland., Arnoldini M; Laboratory for Food Immunology, ETH Zürich, Zürich, Switzerland., Scheiber J; BioVariance GmbH, Waldsassen, Germany., Matysik S; Institute of Clinical Chemistry and Laboratory Medicine, Functional Lipidomics and Metabolism Research, University Hospital Regensburg, Regensburg, Germany., Klingenspor M; Chair of Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich, Freising, Germany., Küster B; Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany.; Bavarian Center for Biomolecular Mass Spectrometry, Technical University of Munich, Freising, Germany., Haller D; Department of Nutrition and Immunology, Technical University of Munich, Freising, Germany., Burkhardt R; Institute of Clinical Chemistry and Laboratory Medicine, Functional Lipidomics and Metabolism Research, University Hospital Regensburg, Regensburg, Germany., Kuipers F; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Ecker J; Institute of Clinical Chemistry and Laboratory Medicine, Functional Lipidomics and Metabolism Research, University Hospital Regensburg, Regensburg, Germany. josef.ecker@ukr.de.; ZIEL Institute for Food and Health, Research Group Lipid Metabolism, Technical University of Munich, Freising, Germany. josef.ecker@ukr.de.
Source: Nature microbiology [Nat Microbiol] 2026 Aug; Vol. 11 (8), pp. 2349-2364. Date of Electronic Publication: 2026 Jul 29.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101674869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2058-5276 (Electronic) Linking ISSN: 20585276 NLM ISO Abbreviation: Nat Microbiol Subsets: MEDLINE
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  Data: Gut microbiota restricts intestinal lipid uptake via modulation of bile phosphatidylcholine metabolism in mice.
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Institute for Laboratory Animal Science, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Hidrobo+M%22">Hidrobo M</searchLink>; ZIEL Institute for Food and Health, Research Group Lipid Metabolism, Technical University of Munich, Freising, Germany.<br /><searchLink fieldCode="AU" term="%22Stecher+B%22">Stecher B</searchLink>; Max von Pettenkofer Institute of Hygiene and Medical Microbiology, Faculty of Medicine, Munich, Germany.; Partner site LMU Munich, German Center for Infection Research, Munich, Germany.; Chair of Intestinal Microbiome, School of Life Sciences, Technical University of Munich, Freising, Germany.<br /><searchLink fieldCode="AU" term="%22Coleman+OI%22">Coleman OI</searchLink>; Department of Nutrition and Immunology, Technical University of Munich, Freising, Germany.<br /><searchLink fieldCode="AU" term="%22Moresi+C%22">Moresi C</searchLink>; Laboratory for Food Immunology, ETH Zürich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Greter+G%22">Greter G</searchLink>; Laboratory for Food Immunology, ETH Zürich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Arnoldini+M%22">Arnoldini M</searchLink>; Laboratory for Food Immunology, ETH Zürich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Scheiber+J%22">Scheiber J</searchLink>; BioVariance GmbH, Waldsassen, Germany.<br /><searchLink fieldCode="AU" term="%22Matysik+S%22">Matysik S</searchLink>; Institute of Clinical Chemistry and Laboratory Medicine, Functional Lipidomics and Metabolism Research, University Hospital Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Klingenspor+M%22">Klingenspor M</searchLink>; Chair of Molecular Nutritional Medicine, TUM School of Life Sciences, Technical University of Munich, Freising, Germany.<br /><searchLink fieldCode="AU" term="%22Küster+B%22">Küster B</searchLink>; Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany.; Bavarian Center for Biomolecular Mass Spectrometry, Technical University of Munich, Freising, Germany.<br /><searchLink fieldCode="AU" term="%22Haller+D%22">Haller D</searchLink>; Department of Nutrition and Immunology, Technical University of Munich, Freising, Germany.<br /><searchLink fieldCode="AU" term="%22Burkhardt+R%22">Burkhardt R</searchLink>; Institute of Clinical Chemistry and Laboratory Medicine, Functional Lipidomics and Metabolism Research, University Hospital Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kuipers+F%22">Kuipers F</searchLink>; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Ecker+J%22">Ecker J</searchLink>; Institute of Clinical Chemistry and Laboratory Medicine, Functional Lipidomics and Metabolism Research, University Hospital Regensburg, Regensburg, Germany. josef.ecker@ukr.de.; ZIEL Institute for Food and Health, Research Group Lipid Metabolism, Technical University of Munich, Freising, Germany. josef.ecker@ukr.de.
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  Data: <searchLink fieldCode="JN" term="%22101674869%22">Nature microbiology</searchLink> [Nat Microbiol] 2026 Aug; Vol. 11 (8), pp. 2349-2364. <i>Date of Electronic Publication: </i>2026 Jul 29.
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