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Statin Use and Genetically Predicted HMG-CoA Reductase Inhibition in Relation to Clonal Hematopoiesis.

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Title: Statin Use and Genetically Predicted HMG-CoA Reductase Inhibition in Relation to Clonal Hematopoiesis.
Authors: Carter PR; The Victor Phillip Dahdaleh Heart & Lung Research Institute, University of Cambridge, Cambridge, United Kingdom., Gozdecka M; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom., Wen S; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals Research and Development, AstraZeneca, Cambridge, United Kingdom., Quirós PM; Department of Biochemistry and Molecular Biology, Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo, Spain.; Instituto de Investigación Sanitaria del Principado de Asturias, ISPA, Oviedo, Spain., Lockhart SM; MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom., Dudek M; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom., Bond L; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom., Richenberg G; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom., Larsson SC; Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.; Medical Epidemiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden., Bromage D; School of Cardiovascular and Metabolic Medicine and Sciences, King's College London British Heart Foundation Centre of Excellence, James Black Centre, London, UK., Mitchell J; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals Research and Development, AstraZeneca, Cambridge, United Kingdom., Huntly B; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom., Libby P; Heart and Vascular Institute, Mass General Brigham and Harvard Medical School, Boston, Massachusetts., Clarke MCH; The Victor Phillip Dahdaleh Heart & Lung Research Institute, University of Cambridge, Cambridge, United Kingdom., Fabre M; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals Research and Development, AstraZeneca, Cambridge, United Kingdom.; Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom., Vassiliou GS; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom., Burgess S; The Victor Phillip Dahdaleh Heart & Lung Research Institute, University of Cambridge, Cambridge, United Kingdom.; MRC Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom., Kar SP; The Li Ka Shing Early Cancer Institute, Department of Oncology, University of Cambridge, Cambridge, United Kingdom.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2026 Jul 13. Date of Electronic Publication: 2026 Jul 13.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Carter+PR%22">Carter PR</searchLink>; The Victor Phillip Dahdaleh Heart & Lung Research Institute, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Gozdecka+M%22">Gozdecka M</searchLink>; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Wen+S%22">Wen S</searchLink>; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals Research and Development, AstraZeneca, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Quirós+PM%22">Quirós PM</searchLink>; Department of Biochemistry and Molecular Biology, Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo, Spain.; Instituto de Investigación Sanitaria del Principado de Asturias, ISPA, Oviedo, Spain.<br /><searchLink fieldCode="AU" term="%22Lockhart+SM%22">Lockhart SM</searchLink>; MRC Metabolic Diseases Unit, Wellcome-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Dudek+M%22">Dudek M</searchLink>; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Bond+L%22">Bond L</searchLink>; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Richenberg+G%22">Richenberg G</searchLink>; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Larsson+SC%22">Larsson SC</searchLink>; Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.; Medical Epidemiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.<br /><searchLink fieldCode="AU" term="%22Bromage+D%22">Bromage D</searchLink>; School of Cardiovascular and Metabolic Medicine and Sciences, King's College London British Heart Foundation Centre of Excellence, James Black Centre, London, UK.<br /><searchLink fieldCode="AU" term="%22Mitchell+J%22">Mitchell J</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals Research and Development, AstraZeneca, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Huntly+B%22">Huntly B</searchLink>; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Libby+P%22">Libby P</searchLink>; Heart and Vascular Institute, Mass General Brigham and Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Clarke+MCH%22">Clarke MCH</searchLink>; The Victor Phillip Dahdaleh Heart & Lung Research Institute, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Fabre+M%22">Fabre M</searchLink>; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals Research and Development, AstraZeneca, Cambridge, United Kingdom.; Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Vassiliou+GS%22">Vassiliou GS</searchLink>; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Burgess+S%22">Burgess S</searchLink>; The Victor Phillip Dahdaleh Heart & Lung Research Institute, University of Cambridge, Cambridge, United Kingdom.; MRC Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Kar+SP%22">Kar SP</searchLink>; The Li Ka Shing Early Cancer Institute, Department of Oncology, University of Cambridge, Cambridge, United Kingdom.
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