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Pre-plaque glutamatergic hyperexcitability, mitochondrial dysfunction, and dendritic remodeling in the hippocampus of one-month-old 5xFAD mice.

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Title: Pre-plaque glutamatergic hyperexcitability, mitochondrial dysfunction, and dendritic remodeling in the hippocampus of one-month-old 5xFAD mice.
Authors: Kelley AR; Linus Pauling Institute, Oregon State University, Corvallis, OR, United States.; Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, United States., Sackinger E; Linus Pauling Institute, Oregon State University, Corvallis, OR, United States.; Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR, United States., Frischman M; Linus Pauling Institute, Oregon State University, Corvallis, OR, United States.; Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR, United States., Thomas N; Linus Pauling Institute, Oregon State University, Corvallis, OR, United States.; Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, United States., Kim K; Linus Pauling Institute, Oregon State University, Corvallis, OR, United States.; Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR, United States., Scuderi G; Linus Pauling Institute, Oregon State University, Corvallis, OR, United States.; Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, United States., Labut EM; Linus Pauling Institute, Oregon State University, Corvallis, OR, United States.; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, United States., MacMurchy D; Linus Pauling Institute, Oregon State University, Corvallis, OR, United States.; Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, United States., Ikea-Mario T; Linus Pauling Institute, Oregon State University, Corvallis, OR, United States.; Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, United States., Rauenhorst J; Linus Pauling Institute, Oregon State University, Corvallis, OR, United States.; Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR, United States., Neitzel E; Linus Pauling Institute, Oregon State University, Corvallis, OR, United States.; Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR, United States., Vu T; Linus Pauling Institute, Oregon State University, Corvallis, OR, United States.; Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR, United States., Liko L; Linus Pauling Institute, Oregon State University, Corvallis, OR, United States.; Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR, United States., Hoff A; Linus Pauling Institute, Oregon State University, Corvallis, OR, United States.; Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR, United States., Hoff A; Linus Pauling Institute, Oregon State University, Corvallis, OR, United States.; Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR, United States., Wallace O; Linus Pauling Institute, Oregon State University, Corvallis, OR, United States.; Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR, United States., Harry WKE; Linus Pauling Institute, Oregon State University, Corvallis, OR, United States.; Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, United States., Hagen B; Linus Pauling Institute, Oregon State University, Corvallis, OR, United States.; Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, United States., Bihun AZ; Linus Pauling Institute, Oregon State University, Corvallis, OR, United States., Abou-Seada IA; Linus Pauling Institute, Oregon State University, Corvallis, OR, United States.; Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR, United States., Lee K; Linus Pauling Institute, Oregon State University, Corvallis, OR, United States.; Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, United States., Butler J; Linus Pauling Institute, Oregon State University, Corvallis, OR, United States.; Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, United States., Nigussie F; Linus Pauling Institute, Oregon State University, Corvallis, OR, United States.; Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR, United States., Ebrahimi A; Department of Chemistry, College of Science, Oregon State University, Corvallis, OR, United States., Lee PY; Department of Chemistry, College of Science, Oregon State University, Corvallis, OR, United States., Marney LC; Department of Chemistry, College of Science, Oregon State University, Corvallis, OR, United States., Maier CS; Department of Chemistry, College of Science, Oregon State University, Corvallis, OR, United States., Magnusson KR; Linus Pauling Institute, Oregon State University, Corvallis, OR, United States.; Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR, United States., Hagen TM; Linus Pauling Institute, Oregon State University, Corvallis, OR, United States.; Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, United States.
Source: Frontiers in aging neuroscience [Front Aging Neurosci] 2026 Jul 15; Vol. 18, pp. 1804332. Date of Electronic Publication: 2026 Jul 15 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101525824 Publication Model: eCollection Cited Medium: Print ISSN: 1663-4365 (Print) Linking ISSN: 16634365 NLM ISO Abbreviation: Front Aging Neurosci Subsets: PubMed not MEDLINE
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  Data: Pre-plaque glutamatergic hyperexcitability, mitochondrial dysfunction, and dendritic remodeling in the hippocampus of one-month-old 5xFAD mice.
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Linus Pauling Institute, Oregon State University, Corvallis, OR, United States.; Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR, United States.<br /><searchLink fieldCode="AU" term="%22Harry+WKE%22">Harry WKE</searchLink>; Linus Pauling Institute, Oregon State University, Corvallis, OR, United States.; Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, United States.<br /><searchLink fieldCode="AU" term="%22Hagen+B%22">Hagen B</searchLink>; Linus Pauling Institute, Oregon State University, Corvallis, OR, United States.; Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, United States.<br /><searchLink fieldCode="AU" term="%22Bihun+AZ%22">Bihun AZ</searchLink>; Linus Pauling Institute, Oregon State University, Corvallis, OR, United States.<br /><searchLink fieldCode="AU" term="%22Abou-Seada+IA%22">Abou-Seada IA</searchLink>; Linus Pauling Institute, Oregon State University, Corvallis, OR, United States.; Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR, United States.<br /><searchLink fieldCode="AU" term="%22Lee+K%22">Lee K</searchLink>; Linus Pauling Institute, Oregon State University, Corvallis, OR, United States.; Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, United States.<br /><searchLink fieldCode="AU" term="%22Butler+J%22">Butler J</searchLink>; Linus Pauling Institute, Oregon State University, Corvallis, OR, United States.; Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, United States.<br /><searchLink fieldCode="AU" term="%22Nigussie+F%22">Nigussie F</searchLink>; Linus Pauling Institute, Oregon State University, Corvallis, OR, United States.; Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR, United States.<br /><searchLink fieldCode="AU" term="%22Ebrahimi+A%22">Ebrahimi A</searchLink>; 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Linus Pauling Institute, Oregon State University, Corvallis, OR, United States.; Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, United States.
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  Data: <searchLink fieldCode="JN" term="%22101525824%22">Frontiers in aging neuroscience</searchLink> [Front Aging Neurosci] 2026 Jul 15; Vol. 18, pp. 1804332. <i>Date of Electronic Publication: </i>2026 Jul 15 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Research+Foundation%22">Frontiers Research Foundation </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101525824 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Print <i>ISSN: </i>1663-4365 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216634365%22">16634365 </searchLink><i>NLM ISO Abbreviation: </i>Front Aging Neurosci <i>Subsets: </i>PubMed not MEDLINE
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