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Over-induction of innate immune responses suppresses T cell response to mRNA SARS-CoV-2 vaccination.

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Title: Over-induction of innate immune responses suppresses T cell response to mRNA SARS-CoV-2 vaccination.
Authors: Tay CJX; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Koh CWT; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore., Ooi JSG; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore., Li HE; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Kang AYH; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Roslan SNB; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Osman NE; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Ong SM; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Ooi DSQ; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Tham EH; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Khoo Teck Puat - National University Children's Medical Institute, National University Hospital, Singapore., Shek LP; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Khoo Teck Puat - National University Children's Medical Institute, National University Hospital, Singapore., Chan KR; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore. Electronic address: kuanrong.chan@duke-nus.edu.sg., Zhong Y; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore; Khoo Teck Puat - National University Children's Medical Institute, National University Hospital, Singapore. Electronic address: youjiazhong@nus.edu.sg.
Source: Vaccine [Vaccine] 2026 Jul 30; Vol. 88, pp. 128983. Date of Electronic Publication: 2026 Jul 30.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8406899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2518 (Electronic) Linking ISSN: 0264410X NLM ISO Abbreviation: Vaccine Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Over-induction of innate immune responses suppresses T cell response to mRNA SARS-CoV-2 vaccination.
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  Data: <searchLink fieldCode="AU" term="%22Tay+CJX%22">Tay CJX</searchLink>; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Koh+CWT%22">Koh CWT</searchLink>; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Ooi+JSG%22">Ooi JSG</searchLink>; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Li+HE%22">Li HE</searchLink>; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Kang+AYH%22">Kang AYH</searchLink>; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Roslan+SNB%22">Roslan SNB</searchLink>; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Osman+NE%22">Osman NE</searchLink>; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ong+SM%22">Ong SM</searchLink>; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ooi+DSQ%22">Ooi DSQ</searchLink>; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tham+EH%22">Tham EH</searchLink>; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Khoo Teck Puat - National University Children's Medical Institute, National University Hospital, Singapore.<br /><searchLink fieldCode="AU" term="%22Shek+LP%22">Shek LP</searchLink>; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Khoo Teck Puat - National University Children's Medical Institute, National University Hospital, Singapore.<br /><searchLink fieldCode="AU" term="%22Chan+KR%22">Chan KR</searchLink>; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore. Electronic address: kuanrong.chan@duke-nus.edu.sg.<br /><searchLink fieldCode="AU" term="%22Zhong+Y%22">Zhong Y</searchLink>; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore; Khoo Teck Puat - National University Children's Medical Institute, National University Hospital, Singapore. Electronic address: youjiazhong@nus.edu.sg.
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  Data: <searchLink fieldCode="JN" term="%228406899%22">Vaccine</searchLink> [Vaccine] 2026 Jul 30; Vol. 88, pp. 128983. <i>Date of Electronic Publication: </i>2026 Jul 30.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>8406899 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-2518 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220264410X%22">0264410X </searchLink><i>NLM ISO Abbreviation: </i>Vaccine <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.vaccine.2026.128983
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              Text: 2026 Jul 30
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