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Macrophage FOLR2 drives liver fibrosis via intercellular engagement of TGFβRII.

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Title: Macrophage FOLR2 drives liver fibrosis via intercellular engagement of TGFβRII.
Authors: Yuan MM; State Key Laboratory of Pharmaceutical Biotechnology, Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, School of Life Sciences, Nanjing University, Nanjing, 210093, China., Zheng BF; State Key Laboratory of Pharmaceutical Biotechnology, Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, School of Life Sciences, Nanjing University, Nanjing, 210093, China., Wang JL; Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Hepatobiliary Institute of Nanjing University, Nanjing, 210093, China., Xu SQ; State Key Laboratory of Pharmaceutical Biotechnology, Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, School of Life Sciences, Nanjing University, Nanjing, 210093, China., Wang SL; State Key Laboratory of Pharmaceutical Biotechnology, Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, School of Life Sciences, Nanjing University, Nanjing, 210093, China., Tan Y; State Key Laboratory of Pharmaceutical Biotechnology, Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, School of Life Sciences, Nanjing University, Nanjing, 210093, China., Feng Y; State Key Laboratory of Pharmaceutical Biotechnology, Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, School of Life Sciences, Nanjing University, Nanjing, 210093, China., Dong XC; State Key Laboratory of Pharmaceutical Biotechnology, Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, School of Life Sciences, Nanjing University, Nanjing, 210093, China., Zhu QH; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, China. zhuqihua@vip.126.com., Yan J; Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China. jyan@sdu.edu.cn., Xu Q; State Key Laboratory of Pharmaceutical Biotechnology, Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, School of Life Sciences, Nanjing University, Nanjing, 210093, China. molpharm@163.com., Wu XX; State Key Laboratory of Pharmaceutical Biotechnology, Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, School of Life Sciences, Nanjing University, Nanjing, 210093, China. xingxin.wu@nju.edu.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2026 Jul 30. Date of Electronic Publication: 2026 Jul 30.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Yuan+MM%22">Yuan MM</searchLink>; State Key Laboratory of Pharmaceutical Biotechnology, Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, School of Life Sciences, Nanjing University, Nanjing, 210093, China.<br /><searchLink fieldCode="AU" term="%22Zheng+BF%22">Zheng BF</searchLink>; State Key Laboratory of Pharmaceutical Biotechnology, Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, School of Life Sciences, Nanjing University, Nanjing, 210093, China.<br /><searchLink fieldCode="AU" term="%22Wang+JL%22">Wang JL</searchLink>; Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Hepatobiliary Institute of Nanjing University, Nanjing, 210093, China.<br /><searchLink fieldCode="AU" term="%22Xu+SQ%22">Xu SQ</searchLink>; State Key Laboratory of Pharmaceutical Biotechnology, Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, School of Life Sciences, Nanjing University, Nanjing, 210093, China.<br /><searchLink fieldCode="AU" term="%22Wang+SL%22">Wang SL</searchLink>; State Key Laboratory of Pharmaceutical Biotechnology, Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, School of Life Sciences, Nanjing University, Nanjing, 210093, China.<br /><searchLink fieldCode="AU" term="%22Tan+Y%22">Tan Y</searchLink>; State Key Laboratory of Pharmaceutical Biotechnology, Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, School of Life Sciences, Nanjing University, Nanjing, 210093, China.<br /><searchLink fieldCode="AU" term="%22Feng+Y%22">Feng Y</searchLink>; State Key Laboratory of Pharmaceutical Biotechnology, Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, School of Life Sciences, Nanjing University, Nanjing, 210093, China.<br /><searchLink fieldCode="AU" term="%22Dong+XC%22">Dong XC</searchLink>; State Key Laboratory of Pharmaceutical Biotechnology, Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, School of Life Sciences, Nanjing University, Nanjing, 210093, China.<br /><searchLink fieldCode="AU" term="%22Zhu+QH%22">Zhu QH</searchLink>; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, China. zhuqihua@vip.126.com.<br /><searchLink fieldCode="AU" term="%22Yan+J%22">Yan J</searchLink>; Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China. jyan@sdu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Xu+Q%22">Xu Q</searchLink>; State Key Laboratory of Pharmaceutical Biotechnology, Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, School of Life Sciences, Nanjing University, Nanjing, 210093, China. molpharm@163.com.<br /><searchLink fieldCode="AU" term="%22Wu+XX%22">Wu XX</searchLink>; State Key Laboratory of Pharmaceutical Biotechnology, Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, School of Life Sciences, Nanjing University, Nanjing, 210093, China. xingxin.wu@nju.edu.cn.
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              Text: 2026 Jul 30
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