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Radio-sensitization of mutated KRAS G12C non-small cell lung cancer with KRAS G12C tyrosine kinase inhibitor and carbon ions irradiation.

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Title: Radio-sensitization of mutated KRAS G12C non-small cell lung cancer with KRAS G12C tyrosine kinase inhibitor and carbon ions irradiation.
Authors: Césaire M; Centre de recherche sur les Ions les Matériaux et la Photonique, Université de Caen Normandie, CEA, CNRS, ENSICAEN, Normandy University, Team Applications in Radiobiology with Accelerated Ions, UMR6252 CIMAP, Bd Becquerel, 14000, Caen, France. m.cesaire@baclesse.unicancer.fr.; Radiation-Oncology Department, Comprehensive Cancer Center François Baclesse, Caen, France. m.cesaire@baclesse.unicancer.fr., Lecrosnier K; Centre de recherche sur les Ions les Matériaux et la Photonique, Université de Caen Normandie, CEA, CNRS, ENSICAEN, Normandy University, Team Applications in Radiobiology with Accelerated Ions, UMR6252 CIMAP, Bd Becquerel, 14000, Caen, France., Montanari J; Centre de recherche sur les Ions les Matériaux et la Photonique, Université de Caen Normandie, CEA, CNRS, ENSICAEN, Normandy University, Team Applications in Radiobiology with Accelerated Ions, UMR6252 CIMAP, Bd Becquerel, 14000, Caen, France., Sitarz M; Centre de recherche sur les Ions les Matériaux et la Photonique, Université de Caen Normandie, CEA, CNRS, ENSICAEN, Normandy University, Team Applications in Radiobiology with Accelerated Ions, UMR6252 CIMAP, Bd Becquerel, 14000, Caen, France.; Normandy University, UNICAEN, CNRS, UMR6534 Corpuscular Physics Laboratory, EnsiCaen, Caen, 14000, France., Messaoudi S; BioTICLA Laboratory, Normandy University, UNICAEN, INSERM U1086 ANTICIPE, Comprehensive Cancer Center François Baclesse, 3 Avenue du Général Harris, 14076, Caen, France., Chartier-Garcia E; University Grenoble Alpes, CEA, CNRS, UMR5249 IRIG-LCBM, 17 avenue des Martyrs, Grenoble, 38054, France., Testard I; University Grenoble Alpes, CEA, CNRS, UMR5249 IRIG-LCBM, 17 avenue des Martyrs, Grenoble, 38054, France., Levallet G; Normandy University, UNICAEN, CNRS, UMR6030 ISTCT, GIP Cyceron, Caen, 14000, France., Christy F; Department of Clinical Research, Comprehensive Cancer Center François Baclesse, Caen, France., Candéias S; University Grenoble Alpes, CEA, CNRS, UMR5249 IRIG-LCBM, 17 avenue des Martyrs, Grenoble, 38054, France., Chevalier F; Centre de recherche sur les Ions les Matériaux et la Photonique, Université de Caen Normandie, CEA, CNRS, ENSICAEN, Normandy University, Team Applications in Radiobiology with Accelerated Ions, UMR6252 CIMAP, Bd Becquerel, 14000, Caen, France. francois.chevalier@ganil.fr.
Source: Molecular and cellular biochemistry [Mol Cell Biochem] 2026 Jul 31. Date of Electronic Publication: 2026 Jul 31.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Netherlands NLM ID: 0364456 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4919 (Electronic) Linking ISSN: 03008177 NLM ISO Abbreviation: Mol Cell Biochem Subsets: MEDLINE
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  Data: Radio-sensitization of mutated KRAS G12C non-small cell lung cancer with KRAS G12C tyrosine kinase inhibitor and carbon ions irradiation.
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  Data: <searchLink fieldCode="AU" term="%22Césaire+M%22">Césaire M</searchLink>; Centre de recherche sur les Ions les Matériaux et la Photonique, Université de Caen Normandie, CEA, CNRS, ENSICAEN, Normandy University, Team Applications in Radiobiology with Accelerated Ions, UMR6252 CIMAP, Bd Becquerel, 14000, Caen, France. m.cesaire@baclesse.unicancer.fr.; Radiation-Oncology Department, Comprehensive Cancer Center François Baclesse, Caen, France. m.cesaire@baclesse.unicancer.fr.<br /><searchLink fieldCode="AU" term="%22Lecrosnier+K%22">Lecrosnier K</searchLink>; Centre de recherche sur les Ions les Matériaux et la Photonique, Université de Caen Normandie, CEA, CNRS, ENSICAEN, Normandy University, Team Applications in Radiobiology with Accelerated Ions, UMR6252 CIMAP, Bd Becquerel, 14000, Caen, France.<br /><searchLink fieldCode="AU" term="%22Montanari+J%22">Montanari J</searchLink>; Centre de recherche sur les Ions les Matériaux et la Photonique, Université de Caen Normandie, CEA, CNRS, ENSICAEN, Normandy University, Team Applications in Radiobiology with Accelerated Ions, UMR6252 CIMAP, Bd Becquerel, 14000, Caen, France.<br /><searchLink fieldCode="AU" term="%22Sitarz+M%22">Sitarz M</searchLink>; Centre de recherche sur les Ions les Matériaux et la Photonique, Université de Caen Normandie, CEA, CNRS, ENSICAEN, Normandy University, Team Applications in Radiobiology with Accelerated Ions, UMR6252 CIMAP, Bd Becquerel, 14000, Caen, France.; Normandy University, UNICAEN, CNRS, UMR6534 Corpuscular Physics Laboratory, EnsiCaen, Caen, 14000, France.<br /><searchLink fieldCode="AU" term="%22Messaoudi+S%22">Messaoudi S</searchLink>; BioTICLA Laboratory, Normandy University, UNICAEN, INSERM U1086 ANTICIPE, Comprehensive Cancer Center François Baclesse, 3 Avenue du Général Harris, 14076, Caen, France.<br /><searchLink fieldCode="AU" term="%22Chartier-Garcia+E%22">Chartier-Garcia E</searchLink>; University Grenoble Alpes, CEA, CNRS, UMR5249 IRIG-LCBM, 17 avenue des Martyrs, Grenoble, 38054, France.<br /><searchLink fieldCode="AU" term="%22Testard+I%22">Testard I</searchLink>; University Grenoble Alpes, CEA, CNRS, UMR5249 IRIG-LCBM, 17 avenue des Martyrs, Grenoble, 38054, France.<br /><searchLink fieldCode="AU" term="%22Levallet+G%22">Levallet G</searchLink>; Normandy University, UNICAEN, CNRS, UMR6030 ISTCT, GIP Cyceron, Caen, 14000, France.<br /><searchLink fieldCode="AU" term="%22Christy+F%22">Christy F</searchLink>; Department of Clinical Research, Comprehensive Cancer Center François Baclesse, Caen, France.<br /><searchLink fieldCode="AU" term="%22Candéias+S%22">Candéias S</searchLink>; University Grenoble Alpes, CEA, CNRS, UMR5249 IRIG-LCBM, 17 avenue des Martyrs, Grenoble, 38054, France.<br /><searchLink fieldCode="AU" term="%22Chevalier+F%22">Chevalier F</searchLink>; Centre de recherche sur les Ions les Matériaux et la Photonique, Université de Caen Normandie, CEA, CNRS, ENSICAEN, Normandy University, Team Applications in Radiobiology with Accelerated Ions, UMR6252 CIMAP, Bd Becquerel, 14000, Caen, France. francois.chevalier@ganil.fr.
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              Text: 2026 Jul 31
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