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Ancestry-Calibrated Polygenic Risk Scores Predict PTSD Trajectories in Recent Trauma Survivors and Interact with Neighborhood Resources.

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Title: Ancestry-Calibrated Polygenic Risk Scores Predict PTSD Trajectories in Recent Trauma Survivors and Interact with Neighborhood Resources.
Authors: Webb EK; Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, 02478, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, 02115, USA.; Duke University School of Medicine, Department of Psychiatry, Durham, NC, USA., Jajoo A; Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, 02478, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, 02115, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Balakundi V; Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, 02478, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Department of Pharmacology, Physiology and Biophysics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, 02118, USA., Sendi MSE; Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, 02478, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, 02115, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, GA, 30302, USA., Koenen KC; Department of Psychiatry, Harvard Medical School, Boston, MA, 02115, USA.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, 02115, USA., Linnstaedt SD; Institute for Trauma Recovery, Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA., House SL; Department of Emergency Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA., An X; Institute for Trauma Recovery, Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA., Stevens JS; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, 30329, USA., Neylan TC; Departments of Psychiatry and Neurology, University of California, San Francisco, San Francisco, CA, 94143, USA., Clifford GD; Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, 30332, USA.; Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30332, USA., Jovanovic T; Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, 48202, USA., Germine LT; Institute for Technology in Psychiatry, McLean Hospital, Belmont, MA, 02478, USA.; The Many Brains Project, Belmont, MA, 02478, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, 02115, USA., Rauch SL; Department of Psychiatry, Harvard Medical School, Boston, MA, 02115, USA.; Institute for Technology in Psychiatry, McLean Hospital, Belmont, MA, 02478, USA., Haran JP; Department of Emergency Medicine, University of Massachusetts Chan Medical School, Worcester, MA, 01655, USA., Storrow AB; Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA., Lewandowski C; Department of Emergency Medicine, Henry Ford Health System, Detroit, MI, 48202, USA., Musey PI Jr; Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA., Hendry PL; Department of Emergency Medicine, University of Florida College of Medicine -Jacksonville, Jacksonville, FL, 32209, USA., Sheikh S; Department of Emergency Medicine, University of Florida College of Medicine -Jacksonville, Jacksonville, FL, 32209, USA., Jones CW; Department of Emergency Medicine, Cooper Medical School of Rowan University, Camden, NJ, 08103, USA., Punches BE; Department of Emergency Medicine, Ohio State University College of Medicine, Columbus, OH, 43210, USA.; Ohio State University College of Nursing, Columbus, OH, 43210, USA., Hudak LA; Department of Emergency Medicine, Emory University School of Medicine, Atlanta, GA, 30329, USA., Pascual JL; Department of Surgery, Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Seamon MJ; Department of Surgery, Division of Traumatology, Surgical Critical Care and Emergency Surgery, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA., Datner EM; Department of Emergency Medicine, Jefferson Einstein Hospital, Jefferson Health, Philadelphia, PA, 19141, USA.; Department of Emergency Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, 19107, USA., Pearson C; Department of Emergency Medicine, Wayne State University, Ascension St. John Hospital, Detroit, MI, 48202, USA., Merchant RC; Department of Emergency Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA., Domeier RM; Department of Emergency Medicine, Trinity Health-Ann Arbor, Ypsilanti, MI, 48197, USA., Rathlev NK; Department of Emergency Medicine, University of Massachusetts Medical School-Baystate, Springfield, MA, 01107, USA., O'Neil BJ; Department of Emergency Medicine, Wayne State University, Detroit Receiving Hospital, Detroit, MI, 48202, USA., Sergot P; Department of Emergency Medicine, McGovern Medical School at UTHealth, Houston, TX, 77030, USA., Sanchez LD; Department of Emergency Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.; Department of Emergency Medicine, Harvard Medical School, Boston, MA, 02115, USA., Bruce SE; Department of Psychological Sciences, University of Missouri - St. Louis, St. Louis, MO, 63121, USA., Harte SE; Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.; Department of Internal Medicine-Rheumatology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA., Kessler RC; Department of Health Care Policy, Harvard Medical School, Boston, MA, 02115, USA., McLean SA; Department of Emergency Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA.; Institute for Trauma Recovery, Department of Anesthesiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA., Ressler KJ; Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, 02478, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, 02115, USA., Daskalakis NP; Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, 02478, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, 02115, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Department of Pharmacology, Physiology and Biophysics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, 02118, USA.; Department of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, MA, 02118, USA., Harnett NG; Division of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, 02478, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, 02115, USA.
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2026 Jul 20. Date of Electronic Publication: 2026 Jul 20.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Ancestry-Calibrated Polygenic Risk Scores Predict PTSD Trajectories in Recent Trauma Survivors and Interact with Neighborhood Resources.
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