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Progranulin deficiency-induced lysosomal dysfunction drives maladaptive myeloid cell states through the MITF/TFE transcription factors.

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Title: Progranulin deficiency-induced lysosomal dysfunction drives maladaptive myeloid cell states through the MITF/TFE transcription factors.
Authors: Tejwani L; Denali Therapeutics Inc., South San Francisco, CA, USA. Electronic address: tejwani.leon@gmail.com., Heffner CM; Denali Therapeutics Inc., South San Francisco, CA, USA., Balak C; Department of Medicine, University of California, San Diego, La Jolla, CA, USA; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA., Skuja LL; Denali Therapeutics Inc., South San Francisco, CA, USA., Tatarakis D; Denali Therapeutics Inc., South San Francisco, CA, USA., Rana A; Denali Therapeutics Inc., South San Francisco, CA, USA., Yu SB; Denali Therapeutics Inc., South San Francisco, CA, USA., Fitzgerald GA; Denali Therapeutics Inc., South San Francisco, CA, USA., Ha C; Denali Therapeutics Inc., South San Francisco, CA, USA., Lunkes de Melo G; Denali Therapeutics Inc., South San Francisco, CA, USA., Sun EW; Denali Therapeutics Inc., South San Francisco, CA, USA., Simon MJ; Denali Therapeutics Inc., South San Francisco, CA, USA., Dugas JC; Denali Therapeutics Inc., South San Francisco, CA, USA., Chow J; Denali Therapeutics Inc., South San Francisco, CA, USA., Thomsen E; Denali Therapeutics Inc., South San Francisco, CA, USA., Sarrafha L; Denali Therapeutics Inc., South San Francisco, CA, USA., Liang E; Denali Therapeutics Inc., South San Francisco, CA, USA., Gould N; Denali Therapeutics Inc., South San Francisco, CA, USA., Suh J; Denali Therapeutics Inc., South San Francisco, CA, USA., Sandmann T; Denali Therapeutics Inc., South San Francisco, CA, USA., Glass CK; Department of Medicine, University of California, San Diego, La Jolla, CA, USA; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA., Di Paolo G; Denali Therapeutics Inc., South San Francisco, CA, USA. Electronic address: gilbert.dipaolo@gmail.com.
Source: Immunity [Immunity] 2026 Aug 11; Vol. 59 (8), pp. 2164-2183.e11. Date of Electronic Publication: 2026 Aug 03.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9432918 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4180 (Electronic) Linking ISSN: 10747613 NLM ISO Abbreviation: Immunity Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Tejwani+L%22">Tejwani L</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA. Electronic address: tejwani.leon@gmail.com.<br /><searchLink fieldCode="AU" term="%22Heffner+CM%22">Heffner CM</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Balak+C%22">Balak C</searchLink>; Department of Medicine, University of California, San Diego, La Jolla, CA, USA; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Skuja+LL%22">Skuja LL</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tatarakis+D%22">Tatarakis D</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Rana+A%22">Rana A</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Yu+SB%22">Yu SB</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Fitzgerald+GA%22">Fitzgerald GA</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ha+C%22">Ha C</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Lunkes+de+Melo+G%22">Lunkes de Melo G</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sun+EW%22">Sun EW</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Simon+MJ%22">Simon MJ</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Dugas+JC%22">Dugas JC</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Chow+J%22">Chow J</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Thomsen+E%22">Thomsen E</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sarrafha+L%22">Sarrafha L</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Liang+E%22">Liang E</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gould+N%22">Gould N</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Suh+J%22">Suh J</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sandmann+T%22">Sandmann T</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Glass+CK%22">Glass CK</searchLink>; Department of Medicine, University of California, San Diego, La Jolla, CA, USA; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Di+Paolo+G%22">Di Paolo G</searchLink>; Denali Therapeutics Inc., South San Francisco, CA, USA. Electronic address: gilbert.dipaolo@gmail.com.
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  Data: <searchLink fieldCode="JN" term="%229432918%22">Immunity</searchLink> [Immunity] 2026 Aug 11; Vol. 59 (8), pp. 2164-2183.e11. <i>Date of Electronic Publication: </i>2026 Aug 03.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Cell+Press%22">Cell Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9432918 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1097-4180 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210747613%22">10747613 </searchLink><i>NLM ISO Abbreviation: </i>Immunity <i>Subsets: </i>MEDLINE
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